1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1002334-12-4
Chemical Name: 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-Phenylpyrazole-4-boronic acid, pinacol ester;1-Phenyl-1H-pyrazole-4-boronic acid picol ester;1-phenyl-1H-pyrazole-4-boronic acid pinacol ester;(1-PHENYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER;1-phenyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-...;1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxanborane-2-YL)-1H-pyrazole;1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB42475893
Molecular Formula: C15H19BN2O2
Formula Weight: 270.13
MOL File: 1002334-12-4.mol

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1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 389.8±15.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -0.58±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C15H19BN2O2/c1-14(2)15(3,4)20-16(19-14)12-10-17-18(11-12)13-8-6-5-7-9-13/h5-11H,1-4H3
InChIKey: XPAJFLOIPDXRRD-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: P399698
Product name: 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 25g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W000782
Product name: 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: ≥97.0%
Packaging: 1g
Price: $119
Updated: 2021/12/16

Synthonix

Product number: P15917
Product name: 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 97%
Packaging: 1g
Price: $160
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-FZ
Product name: 1-Phenylpyrazole-4-boronic acid, pinacol ester
Purity: 97%
Packaging: 1g
Price: $184
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0003296
Product name: 1-PHENYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOLE
Purity: 95.00%
Packaging: 1G
Price: $413.7
Updated: 2021/12/16

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1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Synthesis

15115-52-3

73183-34-3

1002334-12-4

The general procedure for the synthesis of 1-phenyl-1H-pyrazole-4-boronic acid pinacol ester from 4-bromo-1-phenyl-1H-pyrazole and biboronic acid pinacol ester was as follows: to a solution of 4-bromo-1-phenyl-1H-pyrazole (0.5 g, 2.3 mmol) in DMSO (50 mL) was added sequentially at room temperature KOAc (0.66 g, 6.8 mmol), bis( pinacolato) diboron (0.63 g, 2.5 mmol) and PdCl2(dppf) (0.076 g, 0.11 mmol). The reaction mixture was stirred at 80 °C overnight. After completion of the reaction, the mixture was diluted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:12) to afford 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.3 g, 50% yield) as a light yellow solid.

References

[1] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 134

1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

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Pure Chemistry Scientific Inc.

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View Lastest Price from 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Career Henan Chemical Co

Product: 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1002334-12-4
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-16

1002334-12-4, 1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

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1-phenyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1-phenyl-1H-pyrazole-4-boronic acid pinacol ester

1-Phenylpyrazole-4-boronic acid, pinacol ester

1H-Pyrazole, 1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

(1-PHENYL-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER

1-Phenyl-1H-pyrazole-4-boronic acid picol ester

1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-...

1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxanborane-2-YL)-1H-pyrazole

1002334-12-4