1-Phenyl-1H-pyrazole-4-carboxylic acid
- Product Name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- CAS No.
- 1134-50-5
- Chemical Name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Synonyms
- AKOS PAO-0321;ASINEX-REAG BAS 16289592;1-phenyl-pyrazole-4-carboxylicaci;1-Phenylpyrazole-4-carboxylic acid;1-phenyl-4-pyrazolecarboxylic acid;Pyrazole-4-carboxylic acid, 1-phenyl-;1-phenyl-1H-pyrazol-4-carboxylic acid;1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 1-phenyl-;1-Phenyl-1H-pyrazole-4-carboxylic acid
- CBNumber
- CB8235699
- Molecular Formula
- C10H8N2O2
- Formula Weight
- 188.18
- MOL File
- 1134-50-5.mol
1-Phenyl-1H-pyrazole-4-carboxylic acid Property
- Melting point:
- 222-227℃
- Boiling point:
- 379.6±15.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 3.75±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 1134-50-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- WGK Germany
- 1
- RTECS
- UQ6436000
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 732478
- Product name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 250mg
- Price
- $117
- Updated
- 2023/06/20
- Product number
- 288299
- Product name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 500mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- P336430
- Product name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 020738
- Product name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 500mg
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 020738
- Product name
- 1-Phenyl-1H-pyrazole-4-carboxylic acid
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
1-Phenyl-1H-pyrazole-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
54605-72-0
1134-50-5
Steps: Sodium hydroxide was dissolved in a 100 mL three-neck reaction flask containing 20 mL of water under nitrogen protection and magnetic stirring. Subsequently, 1-phenyl-1H-pyrazole-4-carbaldehyde was added in one go. Persistent insoluble products were observed even at temperatures of 45-50 °C. Hydrogen peroxide was added to the suspension in six portions over a period of 50 min. After the reaction lasted for 5 h at 50 °C, monitoring by TLC showed that most of the raw material remained. Next, 10 mL of 1N NaOH solution (containing 0.4 g NaOH) and 5 g aqueous hydrogen peroxide were added. After continued stirring at 50 °C for 1 h, the insoluble product completely disappeared and TLC monitoring confirmed that the starting material had been completely consumed (color developer: dinitrophenylhydrazine). The reaction mixture was cooled to room temperature and poured into 150 mL of ice/2N HCl mixture (2:1 volume ratio). After stirring for 30 min, the white precipitate formed was filtered through a Brinell's funnel and washed three times with water. The precipitate was dissolved in 250 mL of ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to give 2.25 g of white solid product (yield: 96%).
References
[1] Inflammopharmacology, 2018, vol. 26, # 1, p. 217 - 226
[2] Patent: US2006/34786, 2006, A1. Location in patent: Page/Page column 62-63
[3] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 4, p. 1265 - 1269
[4] Patent: US2009/239810, 2009, A1. Location in patent: Page/Page column 72
1-Phenyl-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Phenyl-1H-pyrazole-4-carboxylic acid manufacturers
- Product
- 1-Phenyl-1H-pyrazole-4-carboxylic acid 1134-50-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10 tons
- Release date
- 2024-08-04
- Product
- 1-Phenyl-1H-pyrazole-4-carboxylic acid 1134-50-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09