ChemicalBook > CAS DataBase List > 1-Phenyl-1H-pyrazole-4-carboxylic acid

1-Phenyl-1H-pyrazole-4-carboxylic acid

Product Name
1-Phenyl-1H-pyrazole-4-carboxylic acid
CAS No.
1134-50-5
Chemical Name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Synonyms
AKOS PAO-0321;ASINEX-REAG BAS 16289592;1-phenyl-pyrazole-4-carboxylicaci;1-Phenylpyrazole-4-carboxylic acid;1-phenyl-4-pyrazolecarboxylic acid;Pyrazole-4-carboxylic acid, 1-phenyl-;1-phenyl-1H-pyrazol-4-carboxylic acid;1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID;1H-Pyrazole-4-carboxylic acid, 1-phenyl-;1-Phenyl-1H-pyrazole-4-carboxylic acid
CBNumber
CB8235699
Molecular Formula
C10H8N2O2
Formula Weight
188.18
MOL File
1134-50-5.mol
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1-Phenyl-1H-pyrazole-4-carboxylic acid Property

Melting point:
222-227℃
Boiling point:
379.6±15.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
form 
solid
pka
3.75±0.10(Predicted)
Appearance
White to off-white Solid
CAS DataBase Reference
1134-50-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
WGK Germany 
1
RTECS 
UQ6436000
HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
732478
Product name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Packaging
250mg
Price
$117
Updated
2023/06/20
TRC
Product number
P336430
Product name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Packaging
50mg
Price
$45
Updated
2021/12/16
Usbiological
Product number
288299
Product name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Packaging
500mg
Price
$347
Updated
2021/12/16
Matrix Scientific
Product number
020738
Product name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Packaging
500mg
Price
$27
Updated
2021/12/16
Matrix Scientific
Product number
020738
Product name
1-Phenyl-1H-pyrazole-4-carboxylic acid
Packaging
1g
Price
$44
Updated
2021/12/16
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1-Phenyl-1H-pyrazole-4-carboxylic acid Chemical Properties,Usage,Production

Synthesis

54605-72-0

1134-50-5

Steps: Sodium hydroxide was dissolved in a 100 mL three-neck reaction flask containing 20 mL of water under nitrogen protection and magnetic stirring. Subsequently, 1-phenyl-1H-pyrazole-4-carbaldehyde was added in one go. Persistent insoluble products were observed even at temperatures of 45-50 °C. Hydrogen peroxide was added to the suspension in six portions over a period of 50 min. After the reaction lasted for 5 h at 50 °C, monitoring by TLC showed that most of the raw material remained. Next, 10 mL of 1N NaOH solution (containing 0.4 g NaOH) and 5 g aqueous hydrogen peroxide were added. After continued stirring at 50 °C for 1 h, the insoluble product completely disappeared and TLC monitoring confirmed that the starting material had been completely consumed (color developer: dinitrophenylhydrazine). The reaction mixture was cooled to room temperature and poured into 150 mL of ice/2N HCl mixture (2:1 volume ratio). After stirring for 30 min, the white precipitate formed was filtered through a Brinell's funnel and washed three times with water. The precipitate was dissolved in 250 mL of ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to give 2.25 g of white solid product (yield: 96%).

References

[1] Inflammopharmacology, 2018, vol. 26, # 1, p. 217 - 226
[2] Patent: US2006/34786, 2006, A1. Location in patent: Page/Page column 62-63
[3] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 4, p. 1265 - 1269
[4] Patent: US2009/239810, 2009, A1. Location in patent: Page/Page column 72

1-Phenyl-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Phenyl-1H-pyrazole-4-carboxylic acid Suppliers

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View Lastest Price from 1-Phenyl-1H-pyrazole-4-carboxylic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-Phenyl-1H-pyrazole-4-carboxylic acid 1134-50-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10 tons
Release date
2024-08-04
Career Henan Chemical Co
Product
1-Phenyl-1H-pyrazole-4-carboxylic acid 1134-50-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

1134-50-5, 1-Phenyl-1H-pyrazole-4-carboxylic acidRelated Search:

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