ChemicalBook > CAS DataBase List > N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

Product Name
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
CAS No.
726169-73-9
Chemical Name
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
Synonyms
Mocetinostat;MGCD0103;MG0103;CS-1929;Mocetinostat, >=98%;CD0103) Mocetinostat;MGCD0103(Mocetinostat);Mocetinostat (MGCD0103);Mocetinostat (MGCD0103,MG0103);MGCD0103; MGCD 0103; MGCD-0103
CBNumber
CB42484945
Molecular Formula
C23H20N6O
Formula Weight
396.44
MOL File
726169-73-9.mol
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N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Property

Melting point:
>170oC (dec.)
Density 
1.340±0.06 g/cm3(Predicted)
storage temp. 
RT
solubility 
Soluble in DMSO (up to 25 mg/ml)
form 
solid
pka
13.13±0.70(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18287
Product name
Mocetinostat
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18287
Product name
Mocetinostat
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18287
Product name
Mocetinostat
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
18287
Product name
Mocetinostat
Purity
≥98%
Packaging
25mg
Price
$374
Updated
2024/03/01
TRC
Product number
M481090
Product name
Mocetinostat
Packaging
5mg
Price
$95
Updated
2021/12/16
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N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Chemical Properties,Usage,Production

Description

Mocetinostat (726169-73-9) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 μM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor suppressor p21WAF1 and inhibits proliferation of human cancer cells.2 Mocetinostat displays antifibrotic effects in ischemic heart failure.3 Attenuates the development of hypersensitivity in models of neuropathic pain.4 Active in vivo.5

Uses

Mocetinostat is a multi-targeted histone deacetylase inhibitor used in cancer therapy. Mocetinostat is undergoing clinical trials for the treatment of various cancers including follicular lymphoma, Hodgkin’s lymphoma and acute myelogenous leukemia.

Definition

ChEBI: N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide is a member of benzamides.

target

HDAC1

References

1) Zhou et al. (2008), Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ulpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor; J. Med. Chem., 51 4072 2) Raeppel et al. (2009), SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4((4-(pyridine-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103); Bioorg. Med. Chem. Lett., 19 644 3) Nural-Guvener et al. (2015), Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure; Int. J. Mol. Sci., 16 11482 4) Denk et al. (2013), HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain; Pain, 154 1668 5) Bonfils et al. (2008), Evaluation of the pharmacodynamics effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay; Clin. Cancer Res., 14 3441

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Suppliers

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View Lastest Price from N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide manufacturers

Career Henan Chemical Co
Product
N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide 726169-73-9
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

726169-73-9, N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamideRelated Search:

ZM 336372 AG 490 17-AAG Troglitazone Acetanilide ACY-1215 Panobinostat JNJ-26481585 Vorinostat Belinostat (PXD101) Entinostat

  • MGCD0103
  • Mocetinostat
  • MGCD0103(Mocetinostat)
  • MG0103
  • Mocetinostat (MGCD0103,MG0103)
  • N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
  • Mocetinostat (MGCD0103)
  • N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Mocetinostat (MGCD0103)
  • Mocetinostat, >=98%
  • N-(2-Aminophenyl)-4-[[[4-(3-pyridyl)pyrimidin-2-yl]amino]methyl]benzamide
  • MGCD0103;MGCD 0103;MGCD-0103;MG0103
  • MGCD0103; MGCD 0103; MGCD-0103
  • CS-1929
  • CD0103) Mocetinostat
  • Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]-
  • N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide USP/EP/BP
  • 726169-73-9
  • C23H20ON6
  • Inhibitor
  • Inhibitors
  • API