Pentetrazol

ChemicalBook > CAS DataBase List > Pentetrazol

Product Name: Pentetrazol
CAS No.: 54-95-5
Chemical Name: Pentetrazol
Synonyms: PTZ;pentylenetetrazol;Tetrazol;Pentetrazole;PENTYLENETETRAZOLE;TT87;Cortis;Corvis;Su-Zol;Corisan
CBNumber: CB4248615
Molecular Formula: C6H10N4
Formula Weight: 138.17
MOL File: 54-95-5.mol

Less

Pentetrazol Property

Melting point:: 59-61 °C (lit.)
Boiling point:: 194 °C/12 mmHg (lit.)
Density: 1.0617 (rough estimate)
refractive index: 1.4910 (estimate)
Flash point:: 194°C/12mm
storage temp.: -20°C
solubility: ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
form: solid
pka: 1.25±0.20(Predicted)
color: White, crystalline powder
Sensitive: Hygroscopic
Merck: 14,7141
BRN: 135492
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS DataBase Reference: 54-95-5(CAS DataBase Reference)
NIST Chemistry Reference: Pentylenetetrazol(54-95-5)
EPA Substance Registry System: Pentetrazol (54-95-5)

Less

Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: XF8225000
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
Toxicity: LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P6500
Product name: Pentylenetetrazole
Packaging: 25g
Price: $98.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: P6500
Product name: Pentylenetetrazole
Packaging: 50g
Price: $188
Updated: 2024/03/01

Alfa Aesar

Product number: L16185
Product name: 1,5-Pentamethylene-1H-tetrazole, 98%
Packaging: 5g
Price: $29.65
Updated: 2024/03/01

Alfa Aesar

Product number: L16185
Product name: 1,5-Pentamethylene-1H-tetrazole, 98%
Packaging: 25g
Price: $90.7
Updated: 2024/03/01

Cayman Chemical

Product number: 18682
Product name: Pentylenetetrazole
Purity: ≥98%
Packaging: 10g
Price: $44
Updated: 2024/03/01

Less

Pentetrazol Chemical Properties,Usage,Production

Description

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABA_A receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABA_A receptor.

Chemical Properties

white crystalline powder

Originator

Pentylenetetrazole,Spectrum Chemicals and

Uses

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Uses

Non-specific CNS stimulant; convulsant; narcotic antagonist.

Uses

analeptic, circulation stimulant

Definition

ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Manufacturing Process

A solution of 9.8 g cyclohexanone and 8.6 g HNO3 in about 250 ml benzene were slowly added dropwise to 20 ml concentrate sulfuric acid in 100 ml benzene by ice cooling and stirring. After ending of a generation of N2 (0.1 moles) to a corresponding quantity of cyclohexane (0.1 moles). Acid layer was diluted with ice, and made neutral with strong alkaline to give a reaction product as oil. Then it was exrtacted with chloroform, all solvents were distilled and the residue was diluted with water. The desired 6,7,8,9tetrahydro-5H-tetrazoloazepine dropped. Yield was 7.5 g after recrystallization from ester or distillation. M.P: 65°C.

brand name

Cardiazol (Knoll).

Therapeutic Function

Analeptic, Central stimulant

General Description

White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.

Air & Water Reactions

Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reactivity Profile

Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.

Fire Hazard

Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.

Biological Activity

CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.

Biochem/physiol Actions

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Safety Profile

A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.

storage

-20°C

Purification Methods

pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]

Pentetrazol Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Pentetrazol Suppliers

Americas 1 Belgium 1 Canada 1 China 81 Europe 1 Germany 2 India 14 Italy 1 Japan 1 Russia 1 Switzerland 2 United Kingdom 5 United States 18 Global 129

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

RYSS TECH LTD

Tel: 400-188-0725 +86 21 34310725 13611771617
Fax: +86 21 34311076
Country: China
ProdList: 2002
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Country: China
ProdList: 2931
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13358
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9951
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 3150
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9294
Advantage: 58

Shanghai QiQiao Biological Technology Co., Ltd.

Tel: 021-37653318; 15221675714
Email: 515366396@qq.com
Country: China
ProdList: 2089
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6038 18902104717
Email: sales@heowns.com
Country: China
ProdList: 20512
Advantage: 60

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 6912
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8617531190177
Email: peter@yan-xi.com
Country: China
ProdList: 5993
Advantage: 58

Xi'an MC Biotech, Co., Ltd.

Tel: 029-89275612 +8618991951683
Fax: 8618991951683
Email: mcbio_sales@163.com
Country: China
ProdList: 2255
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551
Fax: 008657185134895
Email: info@afinechem.com
Country: CHINA
ProdList: 15377
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

Shanghai jingkang bioengineering co., ltd.

Tel: 021-54721350 13524668266
Fax: 021-5
Email: 2881505714@qq.com
Country: China
ProdList: 7878
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4196
Advantage: 58

Shandong Nayazuo Chemical Technology Co. LTD

Tel: 400-873-6778 18660992876
Fax: 0539-6267369
Email: 3584419101@qq.com
Country: China
ProdList: 4975
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 9946
Advantage: 58

Shanghai kadel chemical technology co., LTD

Tel: 021-4007787-550 400-7787-550
Email: 2850202386@qq.com
Country: China
ProdList: 10618
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11732
Advantage: 58

Shanghai Boer Chemical Reagent Co., LTD

Tel: 19102157732
Email: zhangmin@boerchina.net
Country: China
ProdList: 7855
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-605-7200 17312445705
Email: sales022@b2star.com
Country: China
ProdList: 3764
Advantage: 58

Shanghai Yingxin Laboratory Equipment Co., Ltd.

Tel: 021-021-59178156 17002132182
Email: 3146474380@qq.com
Country: China
ProdList: 11609
Advantage: 58

Shanghai klamar Reagent Co., LTD

Tel: 4001650900 13817534909
Email: 3003940895@qq.com
Country: China
ProdList: 9345
Advantage: 58

Less

View Lastest Price from Pentetrazol manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: pentetrazol 54-95-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-06

Career Henan Chemical Co

Product: Pentetrazol 54-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

54-95-5, PentetrazolRelated Search:

1,2,3-1H-Triazole 1H-Tetrazole-1-acetic acid Nitrotetrazolium blue chloride Ribavirin Dimethyl sulfoxide Tebuconazole Oxymetholone Methylene Blue trihydrate Tolyltriazole 5-Methyl-1H-benzotriazole Tetrazole 1H-Benzotriazole 2,3,5-Triphenyltetrazolium chloride 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE Penconazole 1-TETRACENE Pentaerythritol 1H-TETRAZOLE

CARDIAZOLE

METRAZOLE

1,5-PENTAMETHYLENETETRAZOLE

1,5-PENTAMETHYLENE-1H-TETRAZOLE

6,7,8,9-TETRAHYDRO-5H-TETRAZOLO-[1,5-A]AZEPINE

6,7,8,9-TETRAHYDRO-5H-TETRAZOLOAZEPINE

ALPHA,BETA-CYCLOPENTAMETHYLENETETRAZOLE

PENTAMETHYLENETETRAZOLE

PENTYLENETETRAZOLE

1,2,3,3a-Tetrazacyclohepta-8a,2-cyclopentadiene

α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole, Pentylenetetrazole

α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole

1,5-Pentamethylenetetrazole,98%

Pentylenetetrazole,α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole

corazole(analeptic)

Corisan

Corsedrol

Cortis

Corvasol

Corvis

Coryvet

Deamocard

Delzol-W

Deumacard

Diovascole

Gewazol

Kardiazol

Korazol

Korazole

Lepazol

Leptazol

Leptazole

Metalex-P

Metrazol

Nauranzol

Naurazol

Nedcardol

Neocardol

Neurazol

Novo cora-vinco

novocora-vinco

Opticor

Pemetesan

Penetiazol

Penetrasol

Penetratsol

Pentacard

Pentacor

Pentamethazol

Pentamethazolum

Pentamethylene-1,5-tetrazole

Pentamethylenetetrazol

5-Pentamethylenetetrazole

Pentetrazole (Cardiazone)

5-a)azepine,6,7,8,9-tetrahydro-5h-tetrazolo(

5-a]azepine,6,7,8,9-tetrahydro-5h-tetrazolo[

5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-

5H-Tetrazoloazepine, 6,7,8,9-tetrahydro-