Pentetrazol

ChemicalBook > CAS DataBase List > Pentetrazol

Product Name: Pentetrazol
CAS No.: 54-95-5
Chemical Name: Pentetrazol
Synonyms: PTZ;pentylenetetrazol;Tetrazol;Pentetrazole;PENTYLENETETRAZOLE;TT87;Cortis;Corvis;Su-Zol;Corisan
CBNumber: CB4248615
Molecular Formula: C6H10N4
Formula Weight: 138.17
MOL File: 54-95-5.mol

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Pentetrazol Property

Melting point:: 59-61 °C (lit.)
Boiling point:: 194 °C/12 mmHg (lit.)
Density: 1.0617 (rough estimate)
refractive index: 1.4910 (estimate)
Flash point:: 194°C/12mm
storage temp.: -20°C
solubility: ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
form: solid
pka: 1.25±0.20(Predicted)
color: White, crystalline powder
Sensitive: Hygroscopic
Merck: 14,7141
BRN: 135492
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS DataBase Reference: 54-95-5(CAS DataBase Reference)
NIST Chemistry Reference: Pentylenetetrazol(54-95-5)
EPA Substance Registry System: Pentetrazol (54-95-5)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: XF8225000
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
Toxicity: LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P6500
Product name: Pentylenetetrazole
Packaging: 25g
Price: $98.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: P6500
Product name: Pentylenetetrazole
Packaging: 50g
Price: $188
Updated: 2024/03/01

Alfa Aesar

Product number: L16185
Product name: 1,5-Pentamethylene-1H-tetrazole, 98%
Packaging: 5g
Price: $29.65
Updated: 2024/03/01

Alfa Aesar

Product number: L16185
Product name: 1,5-Pentamethylene-1H-tetrazole, 98%
Packaging: 25g
Price: $90.7
Updated: 2024/03/01

Cayman Chemical

Product number: 18682
Product name: Pentylenetetrazole
Purity: ≥98%
Packaging: 10g
Price: $44
Updated: 2024/03/01

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Pentetrazol Chemical Properties,Usage,Production

Description

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABA_A receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABA_A receptor.

Chemical Properties

white crystalline powder

Originator

Pentylenetetrazole,Spectrum Chemicals and

Uses

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Uses

Non-specific CNS stimulant; convulsant; narcotic antagonist.

Uses

analeptic, circulation stimulant

Definition

ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Manufacturing Process

A solution of 9.8 g cyclohexanone and 8.6 g HNO3 in about 250 ml benzene were slowly added dropwise to 20 ml concentrate sulfuric acid in 100 ml benzene by ice cooling and stirring. After ending of a generation of N2 (0.1 moles) to a corresponding quantity of cyclohexane (0.1 moles). Acid layer was diluted with ice, and made neutral with strong alkaline to give a reaction product as oil. Then it was exrtacted with chloroform, all solvents were distilled and the residue was diluted with water. The desired 6,7,8,9tetrahydro-5H-tetrazoloazepine dropped. Yield was 7.5 g after recrystallization from ester or distillation. M.P: 65°C.

brand name

Cardiazol (Knoll).

Therapeutic Function

Analeptic, Central stimulant

General Description

White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.

Air & Water Reactions

Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reactivity Profile

Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.

Fire Hazard

Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.

Biological Activity

CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.

Biochem/physiol Actions

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Safety Profile

A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.

storage

-20°C

Purification Methods

pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]

Pentetrazol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pentetrazol manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: pentetrazol 54-95-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-06

Career Henan Chemical Co

Product: Pentetrazol 54-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

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PENTYLENETETRAZOLE

1,2,3,3a-Tetrazacyclohepta-8a,2-cyclopentadiene

α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole, Pentylenetetrazole

α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole

1,5-Pentamethylenetetrazole,98%

Pentylenetetrazole,α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole

corazole(analeptic)

Corisan

Corsedrol

Cortis

Corvasol

Corvis

Coryvet

Deamocard

Delzol-W

Deumacard

Diovascole

Gewazol

Kardiazol

Korazol

Korazole

Lepazol

Leptazol

Leptazole

Metalex-P

Metrazol

Nauranzol

Naurazol

Nedcardol

Neocardol

Neurazol

Novo cora-vinco

novocora-vinco

Opticor

Pemetesan

Penetiazol

Penetrasol

Penetratsol

Pentacard

Pentacor

Pentamethazol

Pentamethazolum

Pentamethylene-1,5-tetrazole

Pentamethylenetetrazol

5-Pentamethylenetetrazole

Pentetrazole (Cardiazone)

5-a)azepine,6,7,8,9-tetrahydro-5h-tetrazolo(

5-a]azepine,6,7,8,9-tetrahydro-5h-tetrazolo[

5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-

5H-Tetrazoloazepine, 6,7,8,9-tetrahydro-