ChemicalBook > CAS DataBase List > Z-Vad-fmk, non-methylated

Z-Vad-fmk, non-methylated

Product Name
Z-Vad-fmk, non-methylated
CAS No.
161401-82-7
Chemical Name
Z-Vad-fmk, non-methylated
Synonyms
Z-VAD;abs817872;Z-VAD-FMK, Free Acid;Z-VAD-FMK (Caspase Inhibitor VI);Z-VAD(OH)-FMK (Caspase Inhibitor VI);Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
CBNumber
CB42497499
Molecular Formula
C21H28FN3O7
Formula Weight
453.46
MOL File
161401-82-7.mol
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Z-Vad-fmk, non-methylated Property

Boiling point:
758.0±60.0 °C(Predicted)
Density 
1.260±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
form 
Off-white solid
pka
3.91±0.19(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219007
Product name
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
Purity
Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
Packaging
250μg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
219007
Product name
Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem<br />Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
Packaging
1mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
14467
Product name
Z-VAD(OH)-FMK
Purity
≥95%
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14467
Product name
Z-VAD(OH)-FMK
Purity
≥95%
Packaging
1mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
14467
Product name
Z-VAD(OH)-FMK
Purity
≥95%
Packaging
5mg
Price
$380
Updated
2024/03/01
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Z-Vad-fmk, non-methylated Chemical Properties,Usage,Production

Description

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

General Description

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

Z-Vad-fmk, non-methylated Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-Vad-fmk, non-methylated Suppliers

Shanghai BRILLIA Pharmaceutical Co., Ltd
Tel
17740884366
Email
derek1229@163.com
Country
China
ProdList
61
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2995
Advantage
58
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15421
Advantage
60
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3404
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60

161401-82-7, Z-Vad-fmk, non-methylatedRelated Search:


  • Z-VAD(OH)-FMK (Caspase Inhibitor VI)
  • Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
  • Z-VAD-FMK (Caspase Inhibitor VI)
  • Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci)
  • L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-
  • Z-VAD-FMK, Free Acid
  • Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem
  • abs817872
  • (5S,8S,11S)-11-(2-Fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid
  • Z-VAD
  • inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase
  • 161401-82-7
  • C21H28FN3O7