ChemicalBook > CAS DataBase List > 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Product Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.: 1048371-03-4
Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Synonyms: CS-874;UPF 1069;UPF 1069 10MG;UPF1069/UPF-1069;UPF 1069, 10 mM in DMSO;UPF 1069;UPF-1069; UPF1069;5-Phenacyloxy-2H-isoquinolin-1-one;5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-
CBNumber: CB42518774
Molecular Formula: C17H13NO3
Formula Weight: 279.29
MOL File: 1048371-03-4.mol

Less

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Property

storage temp.: Store at RT
solubility: Soluble in DMSO (up to 40 mg/ml).
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Less

Safety

Hazard Codes: Xn
Risk Statements: 22

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 50mg
Price: $381
Updated: 2024/03/01

TRC

Product number: U800095
Product name: UPF1069
Packaging: 50mg
Price: $455
Updated: 2021/12/16

Less

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production

Description

UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4

Uses

UPF 1069, is a Selective PARP-2 inhibitor.

IC 50

PARP-2: 0.3 μM (IC₅₀); PARP-1: 8 μM (IC₅₀)

References

[1] ROBERTO PELLICCIARI PROF. On the Way to Selective PARP-2 Inhibitors. Design, Synthesis, and Preliminary Evaluation of a Series of Isoquinolinone Derivatives[J]. ChemMedChem, 2008, 3 6: 914-923. DOI:10.1002/cmdc.200800010
[2] ANN-GERD THORSELL. Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors[J]. Journal of Medicinal Chemistry, 2016, 60 4: 1262-1271. DOI:10.1021/acs.jmedchem.6b00990
[3] F MORONI. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage[J]. British Journal of Pharmacology, 2009, 157 5: 854-862. DOI:10.1111/j.1476-5381.2009.00232.x
[4] BIN GUI. Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2019: 14573-14582. DOI:10.1073/pnas.1908547116

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Suppliers

China 97 India 1 United Kingdom 1 United States 20 Global 119

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Shanghai Uchem Inc.

Tel: 15618758386; 15618758386
Fax: QQ:3004479444
Email: sales3@myuchem.com
Country: China
ProdList: 1999
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1944
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Zhengzhou Ruke Biological Co., Ltd.

Tel: 15981811963
Fax: QQ：1410472904
Email: 1410472904@qq.com
Country: China
ProdList: 5825
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9992
Advantage: 58

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
Fax: -
Email: 1639466865@qq.com
Country: China
ProdList: 498
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3277
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3934
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9778
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Less

View Lastest Price from 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one manufacturers

Career Henan Chemical Co

Product: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one 1048371-03-4
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

1048371-03-4, 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-oneRelated Search:

TCPOBOP TYRPHOSTIN AG 1296 ZM 336372 SU 4312 2-Ethoxyethanol Benzyl alcohol Phenethyl alcohol TPP 4'-Hydroxyacetophenone URMC-099 UNBS-5162 Binimetinib Selumetinib LCL-161 Entinostat Batimastat Olaparib

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

UPF 1069

5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone

1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-

UPF 1069;UPF-1069; UPF1069

UPF 1069 10MG

UPF1069/UPF-1069

CS-874

6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one USP/EP/BP

5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one

UPF 1069, 10 mM in DMSO

5-Phenacyloxy-2H-isoquinolin-1-one

1048371-03-4

Inhibitors

Inhibitor