5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

ChemicalBook > CAS DataBase List > 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Product Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.: 1048371-03-4
Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Synonyms: CS-874;UPF 1069;UPF 1069 10MG;UPF1069/UPF-1069;UPF 1069;UPF-1069; UPF1069;5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-;6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-;5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
CBNumber: CB42518774
Molecular Formula: C17H13NO3
Formula Weight: 279.29
MOL File: 1048371-03-4.mol

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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Property

storage temp.: Store at RT
solubility: Soluble in DMSO (up to 40 mg/ml).
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 17760
Product name: UPF-1069
Purity: ≥98%
Packaging: 50mg
Price: $381
Updated: 2024/03/01

TRC

Product number: U800095
Product name: UPF1069
Packaging: 50mg
Price: $455
Updated: 2021/12/16

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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production

Description

UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4

Uses

UPF 1069, is a Selective PARP-2 inhibitor.

References

1) Pellicciari?et al.?(2008),?On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem.,?3?914 2) Thorsell?et al.?(2017),?Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors; J. Med. Chem.,?60?1262 3) Moroni?et al.?(2009),?Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage; Br. J. Pharmacol.,?157?854 4) Gui?et al.?(2019),?Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function; Proc. Natl. Acad. Sci. USA,?116?14573

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one manufacturers

Career Henan Chemical Co

Product: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one 1048371-03-4
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

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5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

UPF 1069

5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone

1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-

UPF 1069;UPF-1069; UPF1069

UPF 1069 10MG

UPF1069/UPF-1069

CS-874

6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-

5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one USP/EP/BP

5-(2-Oxo-2-phenylethoxy)isoquinolin-1(2H)-one

1048371-03-4

Inhibitors

Inhibitor