5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
- Product Name
- 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
- CAS No.
- 1048371-03-4
- Chemical Name
- 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
- Synonyms
- CS-874;UPF 1069;UPF 1069 10MG;UPF1069/UPF-1069;UPF 1069;UPF-1069; UPF1069;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-;6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-;5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one;5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one USP/EP/BP
- CBNumber
- CB42518774
- Molecular Formula
- C17H13NO3
- Formula Weight
- 279.29
- MOL File
- 1048371-03-4.mol
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Property
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 40 mg/ml).
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17760
- Product name
- UPF-1069
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17760
- Product name
- UPF-1069
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 17760
- Product name
- UPF-1069
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 17760
- Product name
- UPF-1069
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- U800095
- Product name
- UPF1069
- Packaging
- 50mg
- Price
- $455
- Updated
- 2021/12/16
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Usage,Production
Description
UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4
Uses
UPF 1069, is a Selective PARP-2 inhibitor.
References
1) Pellicciari?et al.?(2008),?On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem.,?3?914 2) Thorsell?et al.?(2017),?Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors; J. Med. Chem.,?60?1262 3) Moroni?et al.?(2009),?Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage; Br. J. Pharmacol.,?157?854 4) Gui?et al.?(2019),?Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function; Proc. Natl. Acad. Sci. USA,?116?14573
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Suppliers
View Lastest Price from 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one manufacturers
- Product
- 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one 1048371-03-4
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20