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Chroman-8-carbaldehyde, 95%

Product Name
Chroman-8-carbaldehyde, 95%
CAS No.
327183-32-4
Chemical Name
Chroman-8-carbaldehyde, 95%
Synonyms
CHROMAN-8-CARBALDEHYDE;chromane-8-carbaldehyde;Chroman-?8-?carboxaldehyde;Chroman-8-carbaldehyde, 95%;3,4-dihydro-2H-chroMene-8-carbaldehyde;3,4-dihydro-2H-1-benzopyran-8-carbaldehyde;2H-1-Benzopyran-8-carboxaldehyde, 3,4-dihydro-
CBNumber
CB42526425
Molecular Formula
C10H10O2
Formula Weight
162.19
MOL File
327183-32-4.mol
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Chroman-8-carbaldehyde, 95% Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C611243
Product name
chroman-8-carbaldehyde
Packaging
100mg
Price
$175
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129612
Product name
CHROMAN-8-CARBALDEHYDE
Purity
95.00%
Packaging
250MG
Price
$716.74
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0129612
Product name
CHROMAN-8-CARBALDEHYDE
Purity
95.00%
Packaging
1G
Price
$879.25
Updated
2021/12/16
Ambeed
Product number
A372113
Product name
Chroman-8-carbaldehyde
Purity
97%
Packaging
100mg
Price
$119
Updated
2021/12/16
Crysdot
Product number
CD11144667
Product name
Chroman-8-carbaldehyde
Purity
97%
Packaging
100mg
Price
$148
Updated
2021/12/16
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Chroman-8-carbaldehyde, 95% Chemical Properties,Usage,Production

Synthesis

68-12-2

206347-33-3

327183-32-4

Step B - Synthesis of compound 21C: n-Butyllithium (20 mL of 2.5 M toluene solution) was added dropwise to a mixed solution of anhydrous THF (240 mL) and hexane (40 mL) for compound 21B (10.9 g, 29.23 mmol) at -78 °C and anhydrous conditions. During the dropwise addition, it was ensured that the internal temperature of the reaction solution did not exceed 5°C. Subsequently, the reaction mixture was warmed to about 100 °C and stirred. n-Butyllithium (5.8 mL of 2.5 M toluene solution) diluted in 20 mL of hexane was slowly added at 5 °C and stirring was continued for 4 hours. After that, the mixture was stirred at 5 °C for 0.5 h. A solution of THF (10 mL) in dimethylformamide (3.38 mL, 43.84 mmol) was added. The reaction mixture was stirred at 5 °C for 10 min before warming up to room temperature and continued stirring for 0.5 h. The reaction was subsequently quenched with 1N HCl aqueous solution (100 mL). The organic and aqueous layers were separated and the aqueous layer was extracted with ether (3 x 200 mL). The combined organic layers were washed with brine (100 mL), dried over magnesium sulfate, filtered and concentrated in vacuum. The resulting residue was purified by Biotage 75-M silica gel column chromatography (elution gradient: 0 to 20% hexane solution of ethyl acetate) to afford compound 21C (4.20 g, 88% yield).1H NMR (400 MHz, CDCl3) δ: 10.41 (s, 1H), 7.64-7.63 (dd, J=1.5 Hz, 8.1 Hz. 1H), 7.25 (d, J=5.13Hz, 1H), 6.89 (t, J=7.3Hz, 1H), 4.30 (t, J=5.1Hz, 2H), 2.83 (t, J=6.2Hz, 2H), 2.09-2.03 (m, 2H).

References

[1] Patent: WO2008/82488, 2008, A1. Location in patent: Page/Page column 143-144

Chroman-8-carbaldehyde, 95% Preparation Products And Raw materials

Raw materials

Preparation Products

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Chroman-8-carbaldehyde, 95% Suppliers

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327183-32-4, Chroman-8-carbaldehyde, 95%Related Search:


  • Chroman-8-carbaldehyde, 95%
  • 3,4-dihydro-2H-chroMene-8-carbaldehyde
  • chromane-8-carbaldehyde
  • 3,4-dihydro-2H-1-benzopyran-8-carbaldehyde
  • Chroman-?8-?carboxaldehyde
  • 2H-1-Benzopyran-8-carboxaldehyde, 3,4-dihydro-
  • CHROMAN-8-CARBALDEHYDE
  • 327183-32-4