ChemicalBook > CAS DataBase List > Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

Product Name: Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
CAS No.: 1269815-17-9
Chemical Name: Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
Synonyms: Novartis;CDK-IN-2;CDK inhibitor 2;CDK inhibitor II;CDK-IN-2, 10 mM in DMSO;Inhibitor,CDK IN 2,inhibit,CDK,Cyclin dependent kinase,CDKIN2;(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide;(3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide;3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-;Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
CBNumber: CB42535542
Molecular Formula: C18H19ClFN3O2
Formula Weight: 363.81
MOL File: 1269815-17-9.mol

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Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Property

Boiling point:: 525.6±50.0 °C(Predicted)
Density: 1.300
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.16±0.20(Predicted)
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0239
Product name: CDK-IN-2
Purity: 98.82%
Packaging: 2mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-0239
Product name: CDK-IN-2
Purity: 98.82%
Packaging: 5mg
Price: $162
Updated: 2021/12/16

ApexBio Technology

Product number: A3293
Product name: CDKinhibitorII
Packaging: 2mg
Price: $173
Updated: 2021/12/16

ChemScene

Product number: CS-0239
Product name: CDK-IN-2
Purity: 98.82%
Packaging: 10mg
Price: $292
Updated: 2021/12/16

ApexBio Technology

Product number: A3293
Product name: CDKinhibitorII
Packaging: 5mg
Price: $347
Updated: 2021/12/16

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Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Chemical Properties,Usage,Production

Uses

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. IC50 Value: <8 nM [1] Target: CDK9 In vitro: In vivo:

IC 50

CDK9/cyclinT1: 8 nM (IC₅₀)

References

[1] Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Preparation Products And Raw materials

Raw materials

Preparation Products

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1269815-17-9, Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amideRelated Search:

CHLORIC ACID Maleic acid Pyruvic acid Decanoic acid Fulvic acid Humic acid Cholic acid Phytic acid

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

(3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide

Novartis

CDK inhibitor II

CDK-IN-2

(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide

CDK inhibitor 2

3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-

Inhibitor,CDK IN 2,inhibit,CDK,Cyclin dependent kinase,CDKIN2

CDK-IN-2, 10 mM in DMSO

1269815-17-9