ChemicalBook > CAS DataBase List > Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide

Product Name
Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
CAS No.
1269815-17-9
Chemical Name
Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
Synonyms
Novartis;CDK-IN-2;CDK inhibitor 2;CDK inhibitor II;CDK-IN-2, 10 mM in DMSO;Inhibitor,CDK IN 2,inhibit,CDK,Cyclin dependent kinase,CDKIN2;(R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide;(3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide;3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-;Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
CBNumber
CB42535542
Molecular Formula
C18H19ClFN3O2
Formula Weight
363.81
MOL File
1269815-17-9.mol
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Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Property

Boiling point:
525.6±50.0 °C(Predicted)
Density 
1.300
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
12.16±0.20(Predicted)
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0239
Product name
CDK-IN-2
Purity
98.82%
Packaging
2mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-0239
Product name
CDK-IN-2
Purity
98.82%
Packaging
5mg
Price
$162
Updated
2021/12/16
ApexBio Technology
Product number
A3293
Product name
CDKinhibitorII
Packaging
2mg
Price
$173
Updated
2021/12/16
ChemScene
Product number
CS-0239
Product name
CDK-IN-2
Purity
98.82%
Packaging
10mg
Price
$292
Updated
2021/12/16
ApexBio Technology
Product number
A3293
Product name
CDKinhibitorII
Packaging
5mg
Price
$347
Updated
2021/12/16
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Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Chemical Properties,Usage,Production

Uses

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. IC50 Value: <8 nM [1] Target: CDK9 In vitro: In vivo:

IC 50

CDK9/cyclinT1: 8 nM (IC50)

References

[1] Keith B Pfister, et al. Heteroaryl compounds as kinase inhibitors. 2011, WO2011026917A1.

Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Preparation Products And Raw materials

Raw materials

Preparation Products

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Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide Suppliers

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1269815-17-9, Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amideRelated Search:

CHLORIC ACID Maleic acid Pyruvic acid Decanoic acid Fulvic acid Humic acid Cholic acid Phytic acid

  • Piperidine-3-carboxylic acid [5-chloro-4-(5-fluoro-2-methoxy-phenyl)-pyridin-2-yl]-amide
  • (3R)-N-[5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-3-piperidinecarboxamide
  • Novartis
  • CDK inhibitor II
  • CDK-IN-2
  • (R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide
  • CDK inhibitor 2
  • 3-Piperidinecarboxamide, N-[5-chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinyl]-, (3R)-
  • Inhibitor,CDK IN 2,inhibit,CDK,Cyclin dependent kinase,CDKIN2
  • CDK-IN-2, 10 mM in DMSO
  • 1269815-17-9