2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile

Application

Product Name: 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile
CAS No.: 675126-27-9
Chemical Name: 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile
Synonyms: Gefitinib PI-2;Gefitinib InterMediate;3-Methoxy-4-(3-(piperidin-1-yl)propoxy)benzonitrile;2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzonitrile;2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile;5-Methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzonitrile;Benzonitrile,2-aMino-4-Methoxy-5-[3-(4-Morpholinyl)propoxy]-;Benzonitrile, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]- (9CI, ACI)
CBNumber: CB42537900
Molecular Formula: C15H21N3O3
Formula Weight: 291.35
MOL File: 675126-27-9.mol

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2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Property

Melting point:: 88℃
Boiling point:: 498.0±45.0 °C(Predicted)
Density: 1.21
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.08±0.10(Predicted)
Appearance: Off-white to light brown Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: Y6568
Product name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Packaging: 10g
Price: $143
Updated: 2021/12/16

AK Scientific

Product number: Y6568
Product name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Packaging: 25g
Price: $281
Updated: 2021/12/16

Ambeed

Product number: A209287
Product name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Purity: 97%
Packaging: 250mg
Price: $13
Updated: 2021/12/16

Ambeed

Product number: A209287
Product name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Purity: 97%
Packaging: 1g
Price: $33
Updated: 2021/12/16

Ambeed

Product number: A209287
Product name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Purity: 97%
Packaging: 5g
Price: $87
Updated: 2021/12/16

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2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Chemical Properties,Usage,Production

Application

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile can be used as an intermediate for gefitinib in the pharmaceutical research and development process.

Synthesis

675126-26-8

675126-27-9

General procedure for the synthesis of 2-amino-4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile from 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile: Sodium dithionite (89%, 81.4 kg) was added to a stirred slurry of 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile (48.8 kg) in water (867 L) , and the resulting mixture was heated to 50 °C. The reaction was completed after about 2 hours. The temperature of the reaction mixture was raised to about 70 °C and a concentrated aqueous hydrochloric acid solution (36%, 270 kg) was slowly added over a period of 3 hours. The resulting mixture was cooled to 20-25 °C while stirring was continued and sodium hydroxide solution (47%, 303.7 kg) was added. The reaction mixture was extracted with dichloromethane (twice, 1082 kg and 541 kg), the organic extracts were combined and washed with deionized water (510 L). Evaporation of the organic phase gave 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile (46.3 kg, 99% yield); melting point 87.5 °C; NMR hydrogen spectrum (DMSO-d6) δ: 1.79 (m, 2H), 2.36 (t, 4H), 2.36 (t, 2H), 3.56 (t, 4H), 3.73 (s, 3H), and 3.86 (t, 2H), 5.66 (br s, 2H), 6.4 (s, 1H), 6.89 (s, 1H); MS: M+H+ 292.

References

[1] Patent: WO2005/23783, 2005, A1. Location in patent: Page/Page column 18
[2] Patent: WO2004/24703, 2004, A1. Location in patent: Page 10
[3] Organic Process Research and Development, 2007, vol. 11, # 5, p. 813 - 816
[4] Patent: CN105503749, 2016, A. Location in patent: Paragraph 0053; 0054; 0055
[5] Patent: CN107586279, 2018, A. Location in patent: Paragraph 0008; 0018

2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile Suppliers

China 93 India 4 United Kingdom 1 United States 3 Global 101

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View Lastest Price from 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile manufacturers

Hebei shuoxi biotechnology co. LTD

Product: 2-amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 675126-27-9
Price: US $50.00/g
Min. Order: 10g
Purity: 99.8%
Supply Ability: 10tons
Release date: 2020-04-17

Career Henan Chemical Co

Product: 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile 675126-27-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

675126-27-9, 2-Amino-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrileRelated Search:

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675126-27-9