3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
- Product Name
- 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
- CAS No.
- 179688-53-0
- Chemical Name
- 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
- Synonyms
- 7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate;4-hydroxy-7-methoxyquinazolin-6-yl acetate;Gefitinib IMpurity VII;Gefitinib interMidiate IV;Gefitinib Intermediate IV;6-Acetoxy-7-methoxy-4-quinazolinol;6-Acetoxy-7-methoxy-4-quinazolinone;6-Acetoxy-7-methoxy-3H-quinazolin-4-one;6-ACETOXY-7-METHPXY-4-(3H)QUINAZOLINONE;6-Acetoxy-7-Methoxy-4(3H)-quinazolinone
- CBNumber
- CB11503967
- Molecular Formula
- C11H10N2O4
- Formula Weight
- 234.21
- MOL File
- 179688-53-0.mol
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Property
- Melting point:
- 293 °C
- Boiling point:
- 390.5±52.0 °C(Predicted)
- Density
- 1.39
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- powder to crystal
- pka
- 0.67±0.20(Predicted)
- color
- White to Yellow
- InChI
- InChI=1S/C11H10N2O4/c1-6(14)17-10-3-7-8(4-9(10)16-2)12-5-13-11(7)15/h3-5H,1-2H3,(H,12,13,15)
- InChIKey
- SOLQIFINSOHAQD-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OC(C)=O)C(OC)=C2)C(=O)NC=1
- CAS DataBase Reference
- 179688-53-0
Safety
- HS Code
- 2933.79.1500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2717
- Product name
- 6-Acetoxy-7-methoxy-3H-quinazolin-4-one
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2026/03/19
- Product number
- A2717
- Product name
- 6-Acetoxy-7-methoxy-3H-quinazolin-4-one
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $78
- Updated
- 2026/03/19
- Product number
- H825780
- Product name
- 4-Hydroxy-7-methoxyquinazolin-6-ylEsterAceticAcid
- Packaging
- 5g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H825780
- Product name
- 4-Hydroxy-7-methoxyquinazolin-6-ylEsterAceticAcid
- Packaging
- 10g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- J96479
- Product name
- 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-ylacetate
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Chemical Properties,Usage,Production
Chemical Properties
Brown solid powder
Uses
4-Hydroxy-7-methoxyquinazolin-6-yl Ester Acetic Acid exhibit potent inhibitory activity against VEGFR-2/HDAC and a human breast cancer cell line MCF-7.
Synthesis
108-24-7
179688-52-9
179688-53-0
6-Hydroxy-7-methoxyquinazolin-4-one (1.92 g, 10 mmol) was placed in acetic anhydride (20 mL) and pyridine (4 mL) was added slowly with stirring. The reaction mixture was heated to 100 °C and kept for 4 hours. After the reaction was completed, it was cooled to room temperature and ice water was added to quench the reaction. The white solid that precipitated was the intermediate 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-ol acetate (M-1, 2.32 g, 99% yield).
References
[1] Patent: CN106632089, 2017, A. Location in patent: Paragraph 0077; 0078; 0079
[2] Patent: CN106045980, 2016, A. Location in patent: Paragraph 0018; 0019; 0020
[3] Patent: EP1785420, 2007, A1. Location in patent: Page/Page column 18
[4] Patent: US2007/149523, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2005/97134, 2005, A2. Location in patent: Page/Page column 13; figure 1
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Suppliers
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View Lastest Price from 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate manufacturers
- Product
- 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2021-10-22
- Product
- 3,4-dihydro-7-methoxy-4-oxo-quinazolin-6-yl acetate 179688-53-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%(HPLC)
- Supply Ability
- 2tons
- Release date
- 2023-12-13
- Product
- 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 179688-53-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-26