CEP-18770

ChemicalBook > CAS DataBase List > CEP-18770

Product Name: CEP-18770
CAS No.: 847499-27-8
Chemical Name: CEP-18770
Synonyms: CS-252;CT 47098;CEP-18770;CIP 18770;NPH 007098;Delanzomib;Delanzomib, >=98%;CEP-18770 (DelanzoMib);DelanzoMib (CEP-18770);DelanzoMib, Free Base, >99%
CBNumber: CB42570998
Molecular Formula: C21H28BN3O5
Formula Weight: 413.28
MOL File: 847499-27-8.mol

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CEP-18770 Property

Melting point:: 178-190°C (dec.)
Density: 1.207
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 9.67±0.43(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Safety

HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23557
Product name: Delanzomib
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23557
Product name: Delanzomib
Purity: ≥95%
Packaging: 5mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 23557
Product name: Delanzomib
Purity: ≥95%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 23557
Product name: Delanzomib
Purity: ≥95%
Packaging: 50mg
Price: $911
Updated: 2024/03/01

Usbiological

Product number: 007917
Product name: Delanzomib
Packaging: 5mg
Price: $602
Updated: 2021/12/16

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CEP-18770 Chemical Properties,Usage,Production

Description

Delanzomib is an orally bioavailable inhibitor of chymotrypsin-like proteasome activity (IC₅₀ = 3.8 nM in isolated human erythrocytes) that only marginally inhibits tryptic and peptidyl glutamyl proteasome activity. Delanzomib pre-treatment (20 nM) in vitro inhibits IκBα degradation, NF-κB activation, and the expression of NF-κB-regulated genes, including IκBα, XIAP, TNF-α, IL-1β, ICAM-1, and VEGF. Delanzomib induces apoptosis in multiple myeloma cell lines and inhibits proliferation in a panel of human hematologic and solid tumor cell lines (IC₅₀s = 5.6-34.2 nM). It reduces tumor weight in an RPMI 8226 human multiple myeloma mouse xenograft model when administered intravenously at doses ranging from 1.5-4 mg/kg twice daily and leads to complete tumor regression at a chronic oral dose of 13 mg/kg. Delanzomib reduces the serum level of circulating cytokines, prevents renal tissue damage, and increases lifespan in a mouse model of fatal lupus nephritis.

Uses

Delanzomib is an orally active proteasome inhibitor. Delanzomib has been shown to down-modulate NF-κB, induce apoptosis, inhibit angiogenesis and M-CSF-RANKL-induced osteoclastogenesis.

Definition

ChEBI: Delanzomib is a C-terminal boronic acid peptide inhibitor which induces apoptosis in multiple myeloma, hematological and solid tumor cell lines. It has a role as a proteasome inhibitor, an apoptosis inducer and an antineoplastic agent. It is a threonine derivative, a phenylpyridine, a C-terminal boronic acid peptide and a secondary alcohol. It is functionally related to a L-threonine.

target

proteasome

CEP-18770 Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP-18770 Suppliers

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View Lastest Price from CEP-18770 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Delanzomib 847499-27-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Delanzomib 847499-27-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: CEP-18770 847499-27-8
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2020-01-07

847499-27-8, CEP-18770Related Search:

CPI-455 Maritoclax GDC-0623 IMR-1 CHIR 99021 trihydrochloride LJI308 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide AZ191 HTH-01-015 GDC-0879 4-iodo-3-nitrobenzamide VBY-825 Bortezomib MLN9708 MK-2206 2HCl (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Oprozomib Carfilzomib

CEP-18770

[(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid

CIP 18770

CT 47098

Delanzomib

NPH 007098

CEP-18770 (DelanzoMib)

DelanzoMib, Free Base, >99%

((R)-1-((2S,3R)-3-Hydroxy-2-(6-phenylpicolinaMido)butanaMido)-3-Methylbutyl)boronic acid

(R)-1-((2S,3R)-3-hydroxy-2-(2-phenylpicolinamido)butanamido)-3-methylbutan-2-ylboronic acid

Delanzomib [(1R)-1-[[(2S,3R)-3-Hydroxy-2-[[(6-phenylpyridin-2-yl)carbonyl]amino]-1-oxobutyl]amino]-3-methylbutyl]boronic acid

Delanzomib, >=98%

DelanzoMib (CEP-18770)

Boronic acid, B-[(1R)-1-[[(2S,3R)-3-hydroxy-1-oxo-2-[[(6-phenyl-2-pyridinyl)carbonyl]aMino]butyl]aMino]-3-Methylbutyl]-

CEP-18770;CEP 18770;CEP18770

CS-252

(1R)-1-[(2S,3R)-3-hydroxy-2-[(6-phenylpyridin-2-yl)formamido]butanamido]-3-methylbutyl]boronic acid

((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)butanamido)-3-methylbutan-2-yl)boronic acid

847499-27-8

C21H28BN3O5

Inhibitor

Inhibitors