2-Chloro-5-Methoxy-pyriMidin-4-ylaMine

Product Name: 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine
CAS No.: 99979-77-8
Chemical Name: 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine
Synonyms: 2-chloro-5-MethoxypyriMidin-4-aMine;2-Chloro-5-Methoxy-4-pyriMidinaMine;4-Amino-2-chloro-5-methoxypyrimidine;4-Pyrimidinamine, 2-chloro-5-methoxy-;2-Chloro-5-Methoxy-pyriMidin-4-ylaMine;2-Chloro-5-Methoxy-pyriMidin-4-ylaMine ISO 9001：2015 REACH
CBNumber: CB42579683
Molecular Formula: C5H6ClN3O
Formula Weight: 159.57
MOL File: 99979-77-8.mol

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2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Property

Melting point:: 181-182 °C (decomp)(Solv: ligroine (8032-32-4))
Boiling point:: 349.6±22.0 °C(Predicted)
Density: 1.398±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.39±0.10(Predicted)
Appearance: White to light brown Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C349755
Product name: 2-Chloro-5-methoxy-4-pyrimidinamine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C349755
Product name: 2-Chloro-5-methoxy-4-pyrimidinamine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR926836
Product name: 2-Chloro-5-methoxy-4-pyrimidinamine
Purity: 97%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143402
Product name: 2-Chloro-5-methoxypyrimidin-4-amine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143402
Product name: 2-Chloro-5-methoxypyrimidin-4-amine
Packaging: 250mg
Price: $62.5
Updated: 2021/12/16

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2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Chemical Properties,Usage,Production

Uses

The preparation and synthesis of 2-Chloro-5-methoxy-4-pyrimidinamine.

Synthesis

19646-07-2

99979-77-8

2-Chloro-5-methoxypyrimidin-4-amine was synthesized as follows: 2,4-dichloro-5-methoxypyrimidine (10 g, 56.17 mmol) was dissolved in 1,4-dioxane (20 mL) under argon protection and stirred at room temperature. Subsequently, ammonium hydroxide (25.5 mL) was slowly added to the solution. The reaction mixture was transferred to a sealed tube, heated to 100 °C and maintained for 21 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the volatile components were evaporated under reduced pressure. The crude product was purified by silica gel column chromatography with 40% ethyl acetate/hexane as eluent to afford 2-chloro-5-methoxypyrimidin-4-amine (8.9 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H-NMR (DMSO-d6, 500MHz): δ7.68 (s, 1H), 3.81 (s, 3H); LC-MS (column: X-Bridge C-18, 50×3.0 mm, 3.5 μm; mobile phase: 0.05% aqueous trifluoroacetic acid/acetonitrile; flow rate: 0.80 mL/min) showed m/z 160 ([M+H]+), retention time 2.18 min; TLC (unfolding agent: 50% ethyl acetate/hexane) showed an Rf value of 0.3.

References

[1] Patent: WO2015/66697, 2015, A1. Location in patent: Paragraph 0345; 0416
[2] Patent: WO2011/59839, 2011, A1. Location in patent: Page/Page column 91
[3] Patent: WO2015/86506, 2015, A1. Location in patent: Page/Page column 103
[4] Patent: CN105218561, 2016, A. Location in patent: Paragraph 0242; 0243; 0244
[5] Patent: WO2009/150240, 2009, A1. Location in patent: Page/Page column 128

2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-Methoxy-pyriMidin-4-ylaMine Suppliers

China 98 India 1 United Kingdom 1 United States 5 Global 105

Adamas Reagent, Ltd.

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Shanghai Hekang Biotechnology Co., Ltd.

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View Lastest Price from 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine 99979-77-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: 2-Chloro-5-Methoxy-pyriMidin-4-ylaMine 99979-77-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

99979-77-8, 2-Chloro-5-Methoxy-pyriMidin-4-ylaMineRelated Search:

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2-Chloro-5-Methoxy-pyriMidin-4-ylaMine ISO 9001：2015 REACH

99979-77-8