2-Chloropyrimidine-4-carbonitrile
Application- Product Name
- 2-Chloropyrimidine-4-carbonitrile
- CAS No.
- 75833-38-4
- Chemical Name
- 2-Chloropyrimidine-4-carbonitrile
- Synonyms
- 2-Amino-4-cyanopyrimidine;2-chloro-4-cyanopyrmidine;2-Chloro-4-cyanopyrimidine;2-ChloropyriMidine-4-carb...;2-Chloro-4-pyrimidinecarbonitrile;4-PyriMidinecarbonitrile,2-chloro-;4-Pyrimidinecarbonitrile, 2-chloro- (7CI,9CI);2-Chloropyrimidine-4-carbonitrile ISO 9001：2015 REACH;2-Chloro-4-cyanopyrimidine, 2-Chloro-4-cyano-1,3-diazine
- CBNumber
- CB51081915
- Molecular Formula
- C5H2ClN3
- Formula Weight
- 139.54
- MOL File
- 75833-38-4.mol
2-Chloropyrimidine-4-carbonitrile Property
- Melting point:
- 53-55°
- Boiling point:
- 331.3±15.0 °C(Predicted)
- Density
- 1.43
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- -4.96±0.20(Predicted)
- color
- Off-white to faint yellow/beige
- InChI
- InChI=1S/C5H2ClN3/c6-5-8-2-1-4(3-7)9-5/h1-2H
- InChIKey
- HXVQPZSXXYOZMP-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C#N)=N1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- 3439
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C428463
- Product name
- 2-Chloropyrimidine-4-carbonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 295671
- Product name
- 2-Chloro-4-pyrimidinecarbonitrile
- Packaging
- 250mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- 37898
- Product name
- 2-Chloropyrimidine-4-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- FC57397
- Product name
- 2-Chloro-4-pyrimidinecarbonitrile
- Packaging
- 5G
- Price
- $420
- Updated
- 2021/12/16
- Product number
- 047834
- Product name
- 2-Chloro-4-pyrimidinecarbonitrile
- Purity
- >95%
- Packaging
- 25g
- Price
- $740
- Updated
- 2021/12/16
2-Chloropyrimidine-4-carbonitrile Chemical Properties,Usage,Production
Application
2-Chloro-4-cyanopyrimidine can be used to prepare 2-chloropyrimidine-4-carboxylic acid, which is a key intermediate for the treatment of hyperphosphatemia and the synthesis of benzylsulfonamide pyrazole kinase inhibitors. It is widely used in the synthesis of many pharmaceutical intermediates both domestically and internationally, and has a very promising market prospect.
Chemical Properties
Light yellow solid
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 1, p. 130, 1964 DOI: 10.1002/jhet.5570010305
Synthesis
7460-56-2
75833-38-4
General procedure for the synthesis of 2-chloro-4-cyanopyrimidine from 2-hydroxypyrimidine-4-carbaldehyde oxime: (Step 7) A mixture of 2-oxo-1,2-dihydropyrimidine-4-carboxaldehyde oxime (72.6 g) in cold (0°C) phosphorochloride (280 ml) was placed under vigorous stirring and slowly heated until the onset of a vigorous reaction was observed, at which point heating was stopped. After the reactants were completely dissolved, N,N-diethylaniline (36.3 mL) was added and the reaction mixture continued to reflux for 30 minutes. Upon completion of the reaction, it was cooled to room temperature and the phosphoryl chloride was evaporated under reduced pressure. The crude product was quenched with ice water (500 mL) and extracted with dichloromethane (5 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated. The residue was purified by short silica gel column chromatography (dichloromethane as eluent). After concentration, the product 2-chloro-4-cyanopyrimidine (63 g, solidified on standing, 86.5% yield) was obtained and used directly in the next reaction.
References
[1] Patent: WO2013/39854, 2013, A1. Location in patent: Page/Page column 39
[2] Patent: WO2005/75468, 2005, A2. Location in patent: Page/Page column 43
2-Chloropyrimidine-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloropyrimidine-4-carbonitrile Suppliers
- Tel
- 025-85767923 18512596075
- Fax
- 025-85767923
- sales@nuoxibio.com
- Country
- China
- ProdList
- 960
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
View Lastest Price from 2-Chloropyrimidine-4-carbonitrile manufacturers
- Product
- 2-Chloropyrimidine-4-carbonitrile 75833-38-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 2-Chloropyrimidine-4-Carbonitrile 75833-38-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09