2-Chloro-4,5-diMethoxy-pyriMidine

Product Name: 2-Chloro-4,5-diMethoxy-pyriMidine
CAS No.: 1333240-17-7
Chemical Name: 2-Chloro-4,5-diMethoxy-pyriMidine
Synonyms: 2-Chloro-4,5-diMethoxy-pyriMidine;Pyrimidine, 2-chloro-4,5-dimethoxy-
CBNumber: CB72579679
Molecular Formula: C6H7ClN2O2
Formula Weight: 174.59
MOL File: 1333240-17-7.mol

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2-Chloro-4,5-diMethoxy-pyriMidine Property

Boiling point:: 290.9±20.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.23±0.29(Predicted)
Appearance: White to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Z2532
Product name: 2-Chloro-4,5-dimethoxy-pyrimidine
Packaging: 100mg
Price: $442
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34354
Product name: 2-chloro-4,5-dimethoxypyrimidine
Purity: 97%
Packaging: 1g
Price: $850
Updated: 2021/12/16

Ambeed

Product number: A203424
Product name: 2-Chloro-4,5-dimethoxypyrimidine
Purity: 95+%
Packaging: 5g
Price: $2111
Updated: 2021/12/16

Ambeed

Product number: A203424
Product name: 2-Chloro-4,5-dimethoxypyrimidine
Purity: 95+%
Packaging: 100mg
Price: $142
Updated: 2021/12/16

Ambeed

Product number: A203424
Product name: 2-Chloro-4,5-dimethoxypyrimidine
Purity: 95+%
Packaging: 250mg
Price: $248
Updated: 2021/12/16

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2-Chloro-4,5-diMethoxy-pyriMidine Chemical Properties,Usage,Production

Uses

2-Chloro-4,5-dimethoxypyrimidine is used as a reactant in the preparation of aryl-substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones as inhibitors of influenza A endonuclease.

Synthesis

67-56-1

19646-07-2

1333240-17-7

1. Preparation of the compound 2-chloro-4,5-dimethoxypyrimidine: 2,4-dichloro-5-methoxypyrimidine (2.37 g, 13.2 mmol) and potassium carbonate (K2CO3, 1.8 g, 13.2 mmol) were dissolved in methanol (MeOH, 50 mL), and the reaction was stirred for 19 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with distilled water and saturated saline. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. Subsequently, purification was carried out by silica gel column chromatography with 0 to 20% ethyl acetate/hexane as eluent to afford the target product 2-chloro-4,5-dimethoxypyrimidine as a white solid (1.70 g, 73% yield). The product was characterized by the following data: melting point 65-67 °C; 1H NMR (400 MHz, CDCl3) δ 7.84 (s, 1H), 4.03 (s, 3H), 3.88 (s, 3H); 13C NMR (100 MHz, CDCl3) δ 161.2, 150.0, 141.7, 138.2, 56.6, 55.0.

References

[1] Patent: WO2014/43252, 2014, A2. Location in patent: Page/Page column 64
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 19, p. 8086 - 8098
[3] Patent: WO2011/109267, 2011, A1. Location in patent: Page/Page column 46-47

2-Chloro-4,5-diMethoxy-pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4,5-diMethoxy-pyriMidine Suppliers

China 23 Global 23

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2-Chloro-4,5-diMethoxy-pyriMidine

Pyrimidine, 2-chloro-4,5-dimethoxy-

1333240-17-7