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Piperazine citrate

Product Name
Piperazine citrate
CAS No.
144-29-6
Chemical Name
Piperazine citrate
Synonyms
ANTEPAR;Pinozan;PARAZINE;Patazine;Piperasol;Citraazine;Coliurinal;PIPERAZINE CITRATE;PiperazineCitrateBp;Tripiperazindicitrat
CBNumber
CB4258805
Molecular Formula
C24H46N6O14
Formula Weight
642.65
MOL File
144-29-6.mol
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Piperazine citrate Property

Melting point:
183-187℃
Boiling point:
208℃[at 101 325 Pa]
Density 
0.741[at 20℃]
vapor pressure 
56.928Pa
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
powder to crystal
color 
White to Almost white
Water Solubility 
54g/L at 24℃
Merck 
14,7464
LogP
-1.15
CAS DataBase Reference
144-29-6(CAS DataBase Reference)
EPA Substance Registry System
Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
1
RTECS 
TL3485000
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P2000000
Product name
Piperazine citrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
P2000000
Price
$150
Updated
2024/03/01
TCI Chemical
Product number
P0449
Product name
Piperazine Citrate Hydrate
Purity
>98.0%(T)
Packaging
25g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
P0449
Product name
Piperazine Citrate Hydrate
Purity
>98.0%(T)
Packaging
500g
Price
$71
Updated
2024/03/01
TRC
Product number
P479890
Product name
Piperazine citrate
Packaging
25g
Price
$140
Updated
2021/12/16
TRC
Product number
P479890
Product name
Piperazine citrate
Packaging
100g
Price
$275
Updated
2021/12/16
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Piperazine citrate Chemical Properties,Usage,Production

Description

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Chemical Properties

Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.

Uses

Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.

Indications

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

brand name

Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).

Flammability and Explosibility

Not classified

Mechanism of action

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Pharmacokinetics

Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.

Piperazine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Piperazine citrate manufacturers

Hebei Duling International Trade Co. LTD
Product
PIPERAZINE CITRATE 144-29-6
Price
US $1.60/kg
Min. Order
1kg
Purity
99
Supply Ability
30tons per month
Release date
2023-03-09
Shanghai Chinqesen Biotechnology Co., Ltd.
Product
Piperazine citrate 144-29-6
Price
US $30.00-10.00/BOX
Min. Order
10BOX
Purity
99
Supply Ability
20TONS
Release date
2023-11-15
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Piperazine citrate 144-29-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min
Supply Ability
10 TONS
Release date
2021-06-24

144-29-6, Piperazine citrateRelated Search:


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