ChemicalBook > CAS DataBase List > (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

Product Name: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
CAS No.: 85977-52-2
Chemical Name: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
Synonyms: Afobazole Impurity 3;Palonosetron Intermediate 1;Palonosetron interMediater B;(S)-1,2,3,4-TETRAHYDRO-NAPHTHOIC ACID;(S)-1,2,3,4-tetrahydro-1-naphtoic Acid;(S)-1,2,3,4-tetrahydro-1-naphthoic acid;(S)-1,2,3,4-TETRAHUDRO-1-NAPHTHOIC ACID;(S)-(-)-1,2,3,4-TETRAHYDRONAPHTHOIC ACID;D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid;(s)-(-)-1,2,3,4-tetrahedro-naphthoic acid
CBNumber: CB4259099
Molecular Formula: C11H12O2
Formula Weight: 176.21
MOL File: 85977-52-2.mol

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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Property

Melting point:: 54-56°C
Boiling point:: 54-56°C
Density: 1.186±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform
form: Solid
pka: 4.28±0.20(Predicted)
color: White
InChI: InChI=1S/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)/t10-/m0/s1
InChIKey: VDLWTJCSPSUGOA-JTQLQIEISA-N
SMILES: [C@@H]1(C(O)=O)C2=C(C=CC=C2)CCC1
CAS DataBase Reference: 85977-52-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-51
Safety Statements: 26-24/25
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T294115
Product name: (S)-1,2,3,4-Tetrahydro-1-naphthoicAcid
Packaging: 2g
Price: $195
Updated: 2021/12/16

Apolloscientific

Product number: OR4201
Product name: (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylicacid
Purity: 98%
Packaging: 5g
Price: $145
Updated: 2021/12/16

Apolloscientific

Product number: OR4201
Product name: (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylicacid
Purity: 98%
Packaging: 10g
Price: $254
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK175855
Product name: (S)-1,2,3,4-Tetrahydro-naphthoicacid
Purity: 98%
Packaging: 1g
Price: $259
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2721-1-S1
Product name: (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylic acid
Purity: 98%
Packaging: 10g
Price: $280
Updated: 2021/12/16

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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of Dipeptidyl Boronate Proteasome Inhibitors.

Synthesis

1914-65-4

85977-52-2

General procedure for the synthesis of (S)-tetrahydronaphthalenecarboxylic acid from 1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid: 15.6 g (0.1 mol) of 1,2,3,4-tetrahydronaphthalenecarboxylic acid and 29.8 g (0.1 mol) of quinine were added to 158 mL of a 50% (v/v) aqueous ethanol solution, and stirred for 30 min at 50 °C until complete dissolution. The progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent ratio of petroleum ether (PE):ethyl acetate (EA) = 1:2. Upon completion of the reaction, the reaction solution was cooled to below 0 °C overnight to promote crystallization. Subsequent to filtration, the solid was collected and dried. The dried solid was recrystallized with 90 mL of ethanol, crystallized again at 0 °C, diafiltrated and dried. The resulting product was dissolved in a mixture of 55 mL of 1 mol/L hydrochloric acid and 100 mL of ethyl acetate in a partitioning operation. The organic phase was dried and filtered and concentrated to obtain the crude product. Finally, the crude product was recrystallized from hexane to give 7.21 g of (S)-1,2,3,4-tetrahydronaphthalenecarboxylic acid in the form of white solid in 43.6% yield.

References

[1] Patent: CN108084176, 2018, A. Location in patent: Paragraph 0093; 0102; 0103; 0104
[2] Arkiv foer Kemi, 1958, vol. 12, p. 161,165
[3] Patent: CN107382697, 2017, A

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Preparation Products And Raw materials

Raw materials

Cinchonine 1,2,3,4-Tetrahydro-1-naphthoic acid Acetone Sodium borohydride Carbon dioxide Tetrahydrofuran Ethyl acetate 1-Tetralone Methanol QUININE SULFATE Phosphorus tribromide Dimethyl carbonate PETROLEUM ETHER Magnesium

Preparation Products

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(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Suppliers

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View Lastest Price from (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-01

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-20

85977-52-2, (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acidRelated Search:

2-Naphthoic acid 2-Tetrahydrofuroic acid 1,2,3,4-Tetrahydronaphthalene 1-Naphthoic acid 1-Tetralone (S)-3-Aminoquinuclidine dihydrochloride NOGALAMYCIN Aclarubicin PEN ACLARUBICIN HYDROCHLORIDE 1,2,3,4-TETRAHEDRO-NAPHTHOIC ACID 5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid (R)-1,2,3,4-TETRAHEDRO-NAPHTHOIC ACID 98.0+% E.E.99.0+%,(R)-1,2,3,4-Tetrahedro-naphthoic acid 1,2,3,4-TETRAHYDRO-2-NAPHTHOIC ACID Marcellomycin (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid AKOS AUF0789 AKOS AUF0790

(1S)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic Acid

D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid

(S)-(-)-1,2,3,4-Tetrahydro-1-naphthoic acid(W.S)

(1S)-1-Carboxy-1,2,3,4-tetrahydronaphthalene, (1S)-1,2,3,4-Tetrahydro-1-naphthoic acid

Palonosetron interMediater B

1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-,(1S)-

(S)-1, 2, 3, 4-Tetrahydronaphthoic acidCAS

(S)-1,2,3,4-Tetrahydro-1-naphthoic Acid,99%e.e.

(S)-1,2,3,4-TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID

(S)-(-)-1,2,3,4-TETRAHYDRONAPHTHOIC ACID

(S)-1,2,3,4-TETRAHYDRO-NAPHTHOIC ACID

(s)-(-)-1,2,3,4-tetrahedro-naphthoic acid

(S)-1,2,3,4-tetrahydro-1-naphthoic acid

(S)-(-)-1,2,3,4-Tetrahedro-1-NaphthoicAcid

(S)-1,2,3,4-TETRAHUDRO-1-NAPHTHOIC ACID

(S)-1,2,3,4-tetrahydro-1-naphtoic Acid

(1S)-1-Carboxy-1,2,3,4-tetrahydronaphthalene

(1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylic acid

Palonosetron Intermediate 1

(S)-1,2,3,4-Tetrahydro-1-naphthoic acid, 98%,

(SH-(-)-1,2,3,4-Tetrahedro-naphthoic acid

(S)-1,2,3,4-Tetrahydro-1-naphthalenecarboxylic acid

Afobazole Impurity 3

85977-52-2

Carboxylic Acids & Deriv.

CHIRAL CHEMICALS

INTERMEDIATESOFPALONOSETRONHYDROCHLORIDE

Aromatics

Chiral Reagents

Intermediates