(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
- Product Name
- (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
- CAS No.
- 85977-52-2
- Chemical Name
- (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid
- Synonyms
- Afobazole Impurity 3;Palonosetron Intermediate 1;Palonosetron interMediater B;(S)-1,2,3,4-TETRAHYDRO-NAPHTHOIC ACID;(S)-1,2,3,4-tetrahydro-1-naphtoic Acid;(S)-1,2,3,4-tetrahydro-1-naphthoic acid;(S)-1,2,3,4-TETRAHUDRO-1-NAPHTHOIC ACID;(S)-(-)-1,2,3,4-TETRAHYDRONAPHTHOIC ACID;D-(-)-1,2,3,4-Tetrahydro-1-naphthoic Acid;(s)-(-)-1,2,3,4-tetrahedro-naphthoic acid
- CBNumber
- CB4259099
- Molecular Formula
- C11H12O2
- Formula Weight
- 176.21
- MOL File
- 85977-52-2.mol
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Property
- Melting point:
- 54-56°C
- Boiling point:
- 54-56°C
- Density
- 1.186±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform
- form
- Solid
- pka
- 4.28±0.20(Predicted)
- color
- White
- InChI
- InChI=1S/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)/t10-/m0/s1
- InChIKey
- VDLWTJCSPSUGOA-JTQLQIEISA-N
- SMILES
- [C@@H]1(C(O)=O)C2=C(C=CC=C2)CCC1
- CAS DataBase Reference
- 85977-52-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T294115
- Product name
- (S)-1,2,3,4-Tetrahydro-1-naphthoicAcid
- Packaging
- 2g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- OR4201
- Product name
- (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- OR4201
- Product name
- (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylicacid
- Purity
- 98%
- Packaging
- 10g
- Price
- $254
- Updated
- 2021/12/16
- Product number
- JK175855
- Product name
- (S)-1,2,3,4-Tetrahydro-naphthoicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $259
- Updated
- 2021/12/16
- Product number
- 2721-1-S1
- Product name
- (1S)-1,2,3,4-Tetrahydronaphthalene-1-carboxylic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $280
- Updated
- 2021/12/16
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Intermediate in the preparation of Dipeptidyl Boronate Proteasome Inhibitors.
Synthesis
1914-65-4
85977-52-2
General procedure for the synthesis of (S)-tetrahydronaphthalenecarboxylic acid from 1,2,3,4-tetrahydro-1-naphthalenecarboxylic acid: 15.6 g (0.1 mol) of 1,2,3,4-tetrahydronaphthalenecarboxylic acid and 29.8 g (0.1 mol) of quinine were added to 158 mL of a 50% (v/v) aqueous ethanol solution, and stirred for 30 min at 50 °C until complete dissolution. The progress of the reaction was monitored by thin layer chromatography (TLC) with the unfolding agent ratio of petroleum ether (PE):ethyl acetate (EA) = 1:2. Upon completion of the reaction, the reaction solution was cooled to below 0 °C overnight to promote crystallization. Subsequent to filtration, the solid was collected and dried. The dried solid was recrystallized with 90 mL of ethanol, crystallized again at 0 °C, diafiltrated and dried. The resulting product was dissolved in a mixture of 55 mL of 1 mol/L hydrochloric acid and 100 mL of ethyl acetate in a partitioning operation. The organic phase was dried and filtered and concentrated to obtain the crude product. Finally, the crude product was recrystallized from hexane to give 7.21 g of (S)-1,2,3,4-tetrahydronaphthalenecarboxylic acid in the form of white solid in 43.6% yield.
References
[1] Patent: CN108084176, 2018, A. Location in patent: Paragraph 0093; 0102; 0103; 0104
[2] Arkiv foer Kemi, 1958, vol. 12, p. 161,165
[3] Patent: CN107382697, 2017, A
(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid manufacturers
- Product
- (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-03
- Product
- (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- (S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid 85977-52-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-20