ChemicalBook > CAS DataBase List > 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride

Product Name
2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
CAS No.
199864-86-3
Chemical Name
2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
Synonyms
MT 500 Hydrochloride;RS 127445 hydrochloride NEW;RS-127445 hydrochloride, 10 mM in DMSO;4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine;2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride;2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride;4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride;2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
CBNumber
CB42609717
Molecular Formula
C17H17ClFN3
Formula Weight
317.7883832
MOL File
199864-86-3.mol
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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Property

Melting point:
158 °C
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to tan
InChI
1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChIKey
MKJPYBJBPRFMHL-UHFFFAOYSA-N
SMILES
Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
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Safety

Hazard Codes 
T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933.59.5300
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R2533
Product name
RS-127445 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$143
Updated
2026/03/19
Sigma-Aldrich
Product number
R2533
Product name
RS-127445 hydrochloride
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$551
Updated
2026/03/19
TCI Chemical
Product number
R0221
Product name
RS-127445 Hydrochloride
Packaging
10MG
Price
$108
Updated
2026/03/19
TCI Chemical
Product number
R0221
Product name
RS-127445 Hydrochloride
Packaging
50MG
Price
$385
Updated
2026/03/19
Cayman Chemical
Product number
23451
Product name
RS 127445 (hydrochloride)
Purity
≥98%
Packaging
1 mg
Price
$32
Updated
2024/03/01
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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Chemical Properties,Usage,Production

Uses

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Biological Activity

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

in vivo

In rats, the fraction of RS-127445 that is bioavailable via the oral or intraperitoneal routes is 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5 mg/kg) produced plasma concentrations predicted to fully saturate accessible 5-HT2B receptors for at least 4 h.RS-127445 (5 mg/kg) is administered to rats by oral, intraperitoneal and intravenous routes. Peak plasma concentrations are rapidly achieved with the highest concentrations being found at the first time-point measured following intravenous and intraperitonael administration (0.08 h) and by 0.25 h following dosing by the oral route of administration. RS-127445 is cleared from plasma with an estimated terminal elimination half-life of approximately 1.7 h. The bioavailability of RS-127445, when administered by the oral and intraperitoneal routes is approximately 14 and 62% of that obtained by intravenous administration. Approximately 60% of an intraperitoneal dose and 14% of the oral dose of RS-127445 (5 mg/kg) is bioavailable[1]. RS-127445 (1-30 mg/kg), dose-dependently reduces faecal output, reaching significance at 10 and 30 mg/kg (n=6-11). In blood and brain, >98% of RS-127445 is protein-bound[2].

IC 50

sPLA2: 5.5 (pKi); 5-HT3 Receptor: <6 (pKi); 5-HT5 Receptor: <6 (pKi); 5-HT6 Receptor: <6 (pKi); 5-HT2A Receptor: 6.3 (pKi); 5-HT2C Receptor: 6.4 (pKi); 5-HT2B Receptor: 9.5 (pKi)

storage

Desiccate at +4°C

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride Suppliers

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199864-86-3, 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, MonohydrochlorideRelated Search:

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  • 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
  • 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
  • 2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride
  • MT 500 Hydrochloride
  • 4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine
  • 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride
  • RS 127445 hydrochloride NEW
  • RS-127445 hydrochloride, 10 mM in DMSO
  • 199864-86-3
  • 17H16FN3HCl