ChemicalBook > CAS DataBase List > (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Product Name
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- CAS No.
- 870281-86-0
- Chemical Name
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Synonyms
- CAL10;CAL-101(N-1);Idelalisib INT;IdelalisibIntermediates 1;CAL-101 (N-1) Intermediate;(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one;2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone;4(3H)-Quinazolinone, 2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-;2-[(1S)-1-aminopropyl]-5-fluoro-3-phenyl-3,4-dihydroquinazolin-4-one;(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- CBNumber
- CB42623630
- Molecular Formula
- C17H16FN3O
- Formula Weight
- 297.33
- MOL File
- 870281-86-0.mol
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(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Property
- Boiling point:
- 455.3±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethanol (Sparingly)
- form
- Solid
- pka
- 8.23±0.29(Predicted)
- color
- Off-White
- InChI
- InChI=1S/C17H16FN3O/c1-2-13(19)16-20-14-10-6-9-12(18)15(14)17(22)21(16)11-7-4-3-5-8-11/h3-10,13H,2,19H2,1H3/t13-/m0/s1
- InChIKey
- BNMGOWXQUZHWIO-ZDUSSCGKSA-N
- SMILES
- N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](N)CC
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A628755
- Product name
- 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
TRC
- Product number
- A628755
- Product name
- 2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
- Packaging
- 2.5g
- Price
- $275
- Updated
- 2021/12/16
AK Scientific
- Product number
- 2965AH
- Product name
- (S)-2-(1-Aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Packaging
- 1g
- Price
- $323
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA96431
- Product name
- 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
- Packaging
- 5G
- Price
- $220
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA96431
- Product name
- 2-[(1S)-1-Aminopropyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone
- Packaging
- 10g
- Price
- $270
- Updated
- 2021/12/16
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(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Chemical Properties,Usage,Production
Uses
2-[(1S)-1-Aminoprpyl]-5-fluoro-3-phenyl-4(3H)-quinazolinone is used as reagent/reactant in synthetic preparation of idelalisib using the HMDS/I2-catalyzed cyclocondensation and Boc deprotection of an (aminobutyrylamino)benzamide to a nonracemic quinazoline as the key step.
Synthesis
870281-85-9
870281-86-0
The general procedure for the synthesis of (S)-2-(1-aminopropyl)-5-fluoro-3-phenyl-4(3H)-quinazolinone from tert-butyl (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate was carried out as follows: the (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl )propyl)carbamic acid tert-butyl ester (220 mg, 0.55 mmol) was dissolved in ethyl acetate (2 mL), followed by a one-time addition of an ethyl acetate solution of hydrogen chloride (2.5 mL, 3.88 M) at room temperature. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the resulting suspension was dissolved in water (20 mL) and the aqueous phase was extracted with ethyl acetate (20 mL) and the pH of the aqueous phase was adjusted with sodium carbonate powder to 8. Subsequently, the aqueous phase was further extracted with ethyl acetate (20 mL x 3). All organic phases were combined, washed with saturated saline (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-2-(1-aminopropyl)-5-fluoro-3-phenyl-4(3H)-quinazolinone as a white powder (163 mg, 100% yield).
References
[1] Patent: CN104513235, 2017, B. Location in patent: Paragraph 1158; 1159; 1160; 1161
[2] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0042; 0043; 0044
[3] Patent: WO2005/113554, 2005, A2. Location in patent: Page/Page column 25
[4] Patent: CN106146411, 2016, A. Location in patent: Paragraph 0035; 0036
[5] Organic Preparations and Procedures International, 2016, vol. 48, # 4, p. 337 - 341
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 870281-86-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
Career Henan Chemical Co
- Product
- (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one 870281-86-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20
870281-86-0, (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-oneRelated Search:
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2-Amino-6-fluorobenzoic acid
BOC-ABU-OH
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
CAL-101
2-Fluoro-6-nitro-N-phenylbenzamide