7,10-Dimethoxy-10-DAB III

Product Name: 7,10-Dimethoxy-10-DAB III
CAS No.: 183133-94-0
Chemical Name: 7,10-Dimethoxy-10-DAB III
Synonyms: 11S;12a;12S;(2aR;4]benz[1;11-dihydroxy-4;6-dimethoxy-4a;7,10-MeO-10-DAB;13-tetramethyl-7;Cabazitaxel IMP
CBNumber: CB42630016
Molecular Formula: C31H40O10
Formula Weight: 572.64
MOL File: 183133-94-0.mol

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7,10-Dimethoxy-10-DAB III Property

Melting point:: >225°C (dec.)
Boiling point:: 675.8±55.0 °C(Predicted)
Density: 1.31
storage temp.: Sealed in dry,Room Temperature
solubility: DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol
pka: 12.82±0.70(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Safety

HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D198890
Product name: 10-Deacetyl-7,10-dimethoxy-BaccatinIII
Packaging: 100mg
Price: $355
Updated: 2021/12/16

Usbiological

Product number: 411612
Product name: 10-Deacetyl-7,10-dimethoxy-Baccatin III
Packaging: 50mg
Price: $460
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD31033
Product name: 7,10-Dimethoxy-10-DAB III)
Packaging: 250mg
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD31033
Product name: 7,10-Dimethoxy-10-DAB III)
Packaging: 5G
Price: $1575
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD31033
Product name: 7,10-Dimethoxy-10-DAB III)
Packaging: 10g
Price: $2625
Updated: 2021/12/16

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7,10-Dimethoxy-10-DAB III Chemical Properties,Usage,Production

Description

Cabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.

Uses

4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.

Synthesis

Solvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.

7,10-Dimethoxy-10-DAB III Preparation Products And Raw materials

Raw materials

Preparation Products

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7,10-Dimethoxy-10-DAB III Suppliers

China 182 China Hong Kong 1 India 6 United Kingdom 2 United States 7 Global 198

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View Lastest Price from 7,10-Dimethoxy-10-DAB III manufacturers

Hebei Senko Biotechnology Co., Ltd.

Product: 7,10-Dimethoxy-10-DAB III 183133-94-0
Price: US $80.00/KG/Tin
Min. Order: 1KG
Purity: 99%
Supply Ability: 10Tons
Release date: 2021-07-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7.10-Dimethoxy-10-DAB III 183133-94-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 7.10-Dimethoxy-10-DAB III 183133-94-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

183133-94-0, 7,10-Dimethoxy-10-DAB IIIRelated Search:

Dapoxetine 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid "7-(triMethylsilyl)-13-O-[((4S,5R)-2,4-diphenyl-4,5-dihydro oxazol-5-yl)carbonyl]baccatin Ⅲ 7-Troc-paclitaxel Cabazitaxel N-3 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III 2',3'-O,N-[(S)-(p-Methoxybenzylidene)]-7-O-(triethylsilyl)paclitaxel Deacetyltaxol 7-O-(TRIETHYLSILYL) BACCATIN III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid Cabazitaxel Docetaxel intermediate 10-Deacetylbaccatin III Paclitaxel Cabazitaxel N-1 (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Docetaxel

7β,10β-diMethoxy-10-deacetylbaccatin III

Cabazitaxel interMediate 1

7,10-MeO-10-DAB

7β,10β-Dimethoxy-10-dabⅢ

7β,10β-diMethoxy-10-DAB-II

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe

7,1-DiMethoxy-1-DAB III

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-oneChemicalBook

(2aR

11-dihydroxy-4

11-methano-5H-cyclodeca[3

11S

12a

12b-dodecahydro-9

12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1

12S

13-tetramethyl-7

2-b]oxet-5-oneChemicalBook

4]benz[1

6-dimethoxy-4a

2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-Methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Cabazitaxel Impurity

7,10-Dimethoxy-10-DAB III (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

4-Deacetyl-4-propionyl Cabazitaxel

Cabazitaxel Impurity 17

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

7,10-Dimethoxy-10-DAB III

(2aR,4S,4aS,6R,9S,11S,12S,12

10-Deacetyl-7,10-dimethoxy-Baccatin III

Cabazitaxel intermediate

Cabazitaxel IMP

Cabazitaxel Deacyl Impurity

Cabazitaxel Initiator 1 impurity A

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-

Cabazitaxel lmpurities

4,6-Dimethoxy Baccatin III

7β,10β-dimethoxy-10-DAB-III

(2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-di...

183133-94-0 7, 10-Dimethoxy-10-DAB III

7,10-dimethoxy -10-DAB

7,10-dimethoxy-Baccatin III

10-Dimethoxy-10-DAB III

7β,10β-diMethoxy-10-deacetylbaccatin III

(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-on

183133-94-0

API

Intermediates

183133-94-0