ChemicalBook > CAS DataBase List > Sarecycline Hydrochloride

Sarecycline Hydrochloride

Product Name: Sarecycline Hydrochloride
CAS No.: 1035979-44-2
Chemical Name: Sarecycline Hydrochloride
Synonyms: Sarecycline;Sarecycline HCl;P005672;P005672 HCl;P005672 (hydrochloride);CS-267;PO05672;PO05672 HCl;P0-05672;P0 05672;Sarecycline(P005672)
CBNumber: CB42648136
Molecular Formula: C24H30ClN3O8
Formula Weight: 523.97
MOL File: 1035979-44-2.mol

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Sarecycline Hydrochloride Property

storage temp.: Store at -20°C
solubility: DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
form: Solid
color: Light yellow to yellow
InChIKey: APPRLAGZQKOUFL-ZKOKXHCXNA-N
SMILES: O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=CC(O)=C3C(=O)C1=C2O)CN(C)OC)=O.Cl |&1:1,9,13,16,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24685
Product name: P005672 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $43
Updated: 2023/01/06

Cayman Chemical

Product number: 24685
Product name: P005672 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $191
Updated: 2023/01/06

Cayman Chemical

Product number: 24685
Product name: P005672 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $359
Updated: 2023/01/06

Cayman Chemical

Product number: 24685
Product name: P005672 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $739
Updated: 2023/01/06

TRC

Product number: S140525
Product name: SarecyclineHydrochloride
Packaging: 50mg
Price: $1575
Updated: 2021/12/16

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Sarecycline Hydrochloride Chemical Properties,Usage,Production

Uses

Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.

Biological Activity

Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.

in vivo

Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model^[1].
Sarecycline can inhibit S. aureus (PD₅₀=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection^[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model^[6].

Animal Model:	Female SD-1 mice (A murine neutropenic thigh wound infection model)^[1]
Dosage:	0.33, 1, 3, or 9?mg/kg
Administration:	Intravenously
Result:	Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.

Animal Model:	Carrageenan-induced footpad edema male Sprague Dawley rats model^[6]
Dosage:	1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
Administration:	Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
Result:	Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

IC 50

Tetracycline

Sarecycline Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sarecycline Hydrochloride manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: Sarecycline
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-22

Shaanxi Dideu New Materials Co. Ltd

Product: Sarecycline Hydrochloride 1035979-44-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-08

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Minocycline Impurity 14
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2024-05-22

1035979-44-2, Sarecycline HydrochlorideRelated Search:

Amicycline Sancycline hydrochloride 9-Monodemethyl Minocycline DISCONTINUED YRJLVLGBPUKKRD-YXALHFAPSA-N 7-Didemethyl Minocycline Dihydrochloride (>85% by HPLC) 4-Chloro-2,6-diaminopyrimidine 4-Epiminocycline Minocycline hydrochloride Tigecycline Metabolite M6 (9-AniMoMinocycline) 2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE MINOXIDIL GLUCURONIDE Minoxidil sulphate Minocycline N-Hydroxymethyl Impurity 7-Monodemethyl Minocycline 2,6-Diamino-4-chloropyrimidine 1-oxide Minoxidil IMpurity D MINOXIDIL-D10 Minocycline Impurity 9

(4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(MethoxyMethylaMino)Methyl]-1,11-dioxo-2-naphthacenecarboxaMide hydrochloride

P005672 HCl

P005672 (hydrochloride)

Sarecycline (hydrochloride)

Sarecycline

4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide hydrochloride P005672 HCl

Sarecycline HCl

(4S,4AS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-

P005672 HCl (Sarecycline HCl)

PO05672 HCl

Minocycline Impurity 14

CS-267

Sarecycline(P005672)

P005672(SARECYCLINE HCL)

P005672

(4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride

P0-05672;P0 05672

Minocycline Impurity 14（Sarecycline）

PO05672

PO05672;SARECYCLINE HCL

Sarecycline(P005672 hydrochloride)

(4s,4as,5ar,12ar)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide

Phenol,3,6-dimethoxy-

13C,2H3]-Sarecycline hydrochloride

(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

Sarecycline (P005672 HCl)

Sarecycline Impurity 9

Sarecycline Impurity 23

1035979-44-2

C24H29N3O8HCl