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Sarecycline Hydrochloride

Product Name
Sarecycline Hydrochloride
CAS No.
1035979-44-2
Chemical Name
Sarecycline Hydrochloride
Synonyms
Sarecycline;Sarecycline HCl;P005672;P005672 HCl;P005672 (hydrochloride);CS-267;PO05672;PO05672 HCl;P0-05672;P0 05672;Sarecycline(P005672)
CBNumber
CB42648136
Molecular Formula
C24H30ClN3O8
Formula Weight
523.97
MOL File
1035979-44-2.mol
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Sarecycline Hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml
form 
Solid
color 
Light yellow to yellow
InChIKey
APPRLAGZQKOUFL-ZKOKXHCXNA-N
SMILES
O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=CC(O)=C3C(=O)C1=C2O)CN(C)OC)=O.Cl |&1:1,9,13,16,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24685
Product name
P005672 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$43
Updated
2023/01/06
Cayman Chemical
Product number
24685
Product name
P005672 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$191
Updated
2023/01/06
Cayman Chemical
Product number
24685
Product name
P005672 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$359
Updated
2023/01/06
Cayman Chemical
Product number
24685
Product name
P005672 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$739
Updated
2023/01/06
TRC
Product number
S140525
Product name
SarecyclineHydrochloride
Packaging
50mg
Price
$1575
Updated
2021/12/16
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Sarecycline Hydrochloride Chemical Properties,Usage,Production

Uses

Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.

Biological Activity

Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.

in vivo

Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].

Animal Model:Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
Dosage:0.33, 1, 3, or 9?mg/kg
Administration:Intravenously
Result:Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.
Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
Dosage:1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
Administration:Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
Result:Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

IC 50

Tetracycline

Sarecycline Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Sarecycline Hydrochloride Suppliers

China 103 India 5 United States 13 Global 121
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Sarecycline Hydrochloride manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
Sarecycline
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-22
Shaanxi Dideu New Materials Co. Ltd
Product
Sarecycline Hydrochloride 1035979-44-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-08
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Minocycline Impurity 14
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2024-05-22

1035979-44-2, Sarecycline HydrochlorideRelated Search:

Amicycline Sancycline hydrochloride 9-Monodemethyl Minocycline DISCONTINUED YRJLVLGBPUKKRD-YXALHFAPSA-N 7-Didemethyl Minocycline Dihydrochloride (>85% by HPLC) 4-Chloro-2,6-diaminopyrimidine 4-Epiminocycline Minocycline hydrochloride Tigecycline Metabolite M6 (9-AniMoMinocycline) 2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE MINOXIDIL GLUCURONIDE Minoxidil sulphate Minocycline N-Hydroxymethyl Impurity 7-Monodemethyl Minocycline 2,6-Diamino-4-chloropyrimidine 1-oxide Minoxidil IMpurity D MINOXIDIL-D10 Minocycline Impurity 9

  • (4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(MethoxyMethylaMino)Methyl]-1,11-dioxo-2-naphthacenecarboxaMide hydrochloride
  • P005672 HCl
  • P005672 (hydrochloride)
  • Sarecycline (hydrochloride)
  • Sarecycline
  • 4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide hydrochloride P005672 HCl
  • Sarecycline HCl
  • (4S,4AS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-
  • P005672 HCl (Sarecycline HCl)
  • PO05672 HCl
  • Minocycline Impurity 14
  • CS-267
  • Sarecycline(P005672)
  • P005672(SARECYCLINE HCL)
  • P005672
  • (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride
  • P0-05672;P0 05672
  • Minocycline Impurity 14（Sarecycline）
  • PO05672
  • PO05672;SARECYCLINE HCL
  • Sarecycline(P005672 hydrochloride)
  • (4s,4as,5ar,12ar)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide
  • Phenol,3,6-dimethoxy-
  • 13C,2H3]-Sarecycline hydrochloride
  • (4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
  • Sarecycline (P005672 HCl)
  • Sarecycline Impurity 9
  • Sarecycline Impurity 23
  • 1035979-44-2
  • C24H29N3O8HCl