ChemicalBook > CAS DataBase List > CCT 241533 hydrochloride

CCT 241533 hydrochloride

Product Name: CCT 241533 hydrochloride
CAS No.: 1431697-96-9
Chemical Name: CCT 241533 hydrochloride
Synonyms: CCT241533 HCl;CCT 241533 hydrochloride;CCT-241533 hydrochloride;CCT241533 (hydrochloride);CCT-241533 HYDROCHLORIDE; CCT 241533 HYDROCHLORIDE;rel-4-Fluoro-2-(4-(((3R,4S)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride;(3R,4S)-rel-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol hydrochloride (1:1)
CBNumber: CB42666608
Molecular Formula: C23H28ClFN4O4
Formula Weight: 478.9442232
MOL File: 1431697-96-9.mol

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CCT 241533 hydrochloride Property

solubility: Soluble in DMSO
form: A crystalline solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19178
Product name: CCT241533 (hydrochloride)
Purity: ≥98%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19178
Product name: CCT241533 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 19178
Product name: CCT241533 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 19178
Product name: CCT241533 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $353
Updated: 2024/03/01

ApexBio Technology

Product number: A3292
Product name: CCT241533hydrochloride
Packaging: 2mg
Price: $134
Updated: 2021/12/16

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CCT 241533 hydrochloride Chemical Properties,Usage,Production

Description

CCT241533 is a selective inhibitor of checkpoint kinase 2 (Chk2; IC₅₀ = 3 nM). In human cancer cell lines, CCT241533 blocks Chk2 activity and potentiates the cytotoxicity of the PARP inhibitors, rucaparib, AG-1447; and olaparib .

Uses

CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM[1].

in vitro

cct241533 inhibited chk2 with an ic50 of 3 nmol/l and showed minimal cross-reactivity against a panel of kinases at 1 mmol/l. cct241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines [1]. moreover, as the most potent chk2 inhibitor identified in the series, cct241533 showed potent selectivity (63-fold) over chk1 and low herg inhibition [2].

IC 50

Chk2: 3 nM (IC₅₀); Chk1: 245 nM (IC₅₀); Chk2: 1.16 nM (Ki)

References

[1] anderson ve, walton mi, eve pd, boxall kj, antoni l, caldwell jj, aherne w, pearl lh, oliver aw, collins i, garrett md. cct241533 is a potent and selective inhibitor of chk2 that potentiates the cytotoxicity of parp inhibitors. cancer res. 2011;71(2):463-72.
[2] caldwell jj, welsh ej, matijssen c, anderson ve, antoni l, boxall k, urban f, hayes a, raynaud fi, rigoreau lj, raynham t, aherne gw, pearl lh, oliver aw, garrett md, collins i. structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. j med chem. 2011;54(2):580-90.

CCT 241533 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1431697-96-9, CCT 241533 hydrochlorideRelated Search:

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CCT 241533 hydrochloride

CCT241533 (hydrochloride)

CCT-241533 hydrochloride

(3R,4S)-rel-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol hydrochloride (1:1)

CCT241533 HCl

CCT-241533 HYDROCHLORIDE; CCT 241533 HYDROCHLORIDE

rel-4-Fluoro-2-(4-(((3R,4S)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl)amino)-6,7-dimethoxyquinazolin-2-yl)phenol hydrochloride

1431697-96-9

C23H27FN4O4HCl

C23H28ClFN4O4