ChemicalBook > CAS DataBase List > N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE

N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE

Uses

Product Name: N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
CAS No.: 405098-33-1
Chemical Name: N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
Synonyms: W-54011;CS-2062;W-54011, 10 mM in DMSO;C5a Receptor Antagonist, W-54011;N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochloride;N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE;chemotaxis,inhibit,orally,W-54011,mobilization,anaphylatoxin,ROS,Reactive Oxygen Species,Ca2+,C5a,neutrophils,Inhibitor,Complement System,W54011,inflammatory,W 54011
CBNumber: CB4268080
Molecular Formula: C30H37ClN2O2
Formula Weight: 493.08
MOL File: 405098-33-1.mol

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N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 3 mg/mL
form: White powder solid.
color: White to light yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 234415
Product name: C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem
Packaging: 1mg
Price: $163
Updated: 2025/07/31

Sigma-Aldrich

Product number: 234415
Product name: C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem
Packaging: 5mg
Price: $504
Updated: 2025/07/31

Cayman Chemical

Product number: 21231
Product name: W-54011
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 21231
Product name: W-54011
Purity: ≥98%
Packaging: 5mg
Price: $187
Updated: 2024/03/01

Cayman Chemical

Product number: 21231
Product name: W-54011
Purity: ≥98%
Packaging: 10mg
Price: $315
Updated: 2024/03/01

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N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

W 54011 is a potent orally active non-peptide C5a receptor antagonist.

Description

W-54011 is an orally bioavailable, nonpeptide antagonist of complement component 5a receptor 1 (C5aR), also known as cluster of differentiation 88 (CD88). W-54011 inhibits ¹²⁵I-rhC5a binding in neutrophils (K_i = 2.2 nM) and C5a-mediated intracellular Ca²⁺ mobilization (IC₅₀ = 3.1 nM). W-54011 is selective and does not affect Ca²⁺ mobilization mediated by other G protein-coupled receptor (GPCR) ligands, N-Formyl-Met-Leu-Phe (fMLF; ), or IL-8 up to a concentration of 10 μM. It inhibits Ca²⁺ mobilization in neutrophils in humans, cynomolgus monkeys, and gerbils, but not in mice, rats, guinea pigs, rabbits, or dogs. At 10 nM, W-54011 also inhibits C5a-mediated migration and vessel formation of human microvascular endothelial cells (HMEC-1).

Uses

W 54011 is a potent orally active non-peptide C5a receptor antagonist.

in vivo

W-54011 (3-30 mg/kg; oral administration; for 4 hours; male mongolian gerbils) treatment inhibited C5a-induced neutropenia in a dose-dependent manner in gerbils^[1].
The species selectivity of W-54011 is examined in rhC5a-induced intracellular Ca²⁺ mobilization of neutrophils in various species. The W-54011 is able to inhibit the response in cynomolgus monkeys and gerbils with IC₅₀ values of 1.7 nM and 3.2 nM, respectively, but not in mice, rats, guinea pigs, rabbits, and dogs^[1].

Animal Model:	Male mongolian gerbils (6-12 weeks) injected with rhC5a^[1]
Dosage:	3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:	Oral administration; for 4 hours
Result:	Inhibited C5a-induced neutropenia in a dose-dependent manner.

storage

Store at -20°C

References

[1] HIROSHI SUMICHIKA. Identification of a potent and orally active non-peptide C5a receptor antagonist.[J]. The Journal of Biological Chemistry, 2002, 277 51: 49403-49407. DOI: 10.1074/jbc.m209672200
[2] RYUJI KURIHARA. C5a promotes migration, proliferation, and vessel formation in endothelial cells.[J]. Inflammation Research, 2010, 59 8: 659-666. DOI: 10.1007/s00011-010-0178-4

N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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405098-33-1, N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDERelated Search:

BenzenesulfonaMide, 4-chloro-N-[1-(2-phenylethyl)-2-piperidinylidene]- (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) W-5 HYDROCHLORIDE W123 Exclusive N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) P-ISOPROPYL-PHENYL-P-TOLYL-AMINE C-(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-METHYLAMINE HYDROCHLORIDE N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE [(4-(DIMETHYLAMINO)PHENYL)METHYL](4-ISOPROPYLPHENYL)AMINE

N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE

N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochloride

W-54011

C5a Receptor Antagonist, W-54011

CS-2062

chemotaxis,inhibit,orally,W-54011,mobilization,anaphylatoxin,ROS,Reactive Oxygen Species,Ca2+,C5a,neutrophils,Inhibitor,Complement System,W54011,inflammatory,W 54011

W-54011, 10 mM in DMSO

405098-33-1