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PHACLOFEN

Product Name: PHACLOFEN
CAS No.: 114012-12-3
Chemical Name: PHACLOFEN
Synonyms: PHACLOFEN;PHACLOFEN GABA(B) RECEPTOR ANTA;3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;3-amino-2-(4-chlorophenyl)*propanephosphonic acid;(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-;Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-;Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci
CBNumber: CB4272748
Molecular Formula: C9H13ClNO3P
Formula Weight: 249.63
MOL File: 114012-12-3.mol

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PHACLOFEN Property

Melting point:: 249-252 °C
Boiling point:: 467.1±55.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: 0.1 M HCl: 13.3 mg/mL
form: solid
pka: 1.87±0.10(Predicted)
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P118
Product name: Phaclofen
Purity: solid
Packaging: 5mg
Price: $227
Updated: 2025/07/31

Sigma-Aldrich

Product number: P118
Product name: Phaclofen
Purity: solid
Packaging: 25mg
Price: $856
Updated: 2025/07/31

Sigma-Aldrich

Product number: P118
Product name: Phaclofen
Purity: solid
Packaging: 100mg
Price: $2590
Updated: 2025/07/31

Usbiological

Product number: 256229
Product name: Phaclofen
Packaging: 10mg
Price: $389
Updated: 2021/12/16

ApexBio Technology

Product number: B6215
Product name: Phaclofen
Packaging: 10mg
Price: $218
Updated: 2021/12/16

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PHACLOFEN Chemical Properties,Usage,Production

Uses

Phaclofen is a selective GABAB?receptor antagonist.

General Description

Phaclofen is a phosphonic acid derivative of baclofen.

Biological Activity

Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

in vivo

Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus^[4].
Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum^[5].
Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes^[3].

Animal Model:	Sprague–Dawley rats (180–250 g)^[4]
Dosage:	2 mg/kg
Administration:	I.p．
Result:	Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus.

Animal Model:	Male Wistar rats (280–320 g)^[5]
Dosage:	2 mg/kg
Administration:	S.c.
Result:	Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.

PHACLOFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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114012-12-3, PHACLOFENRelated Search:

3-Aminopropylphosphonic acid PHACLOFEN P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE (2-phenylethyl)phosphonic acid

3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID

PHACLOFEN

(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID

3-amino-2-(4-chlorophenyl)*propanephosphonic acid

PHACLOFEN GABA(B) RECEPTOR ANTA

Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-

Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-

Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci

114012-12-3

C9H13CINO3P

C9H13ClNO3P

GABA/Glycine receptor