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PHACLOFEN

Product Name
PHACLOFEN
CAS No.
114012-12-3
Chemical Name
PHACLOFEN
Synonyms
PHACLOFEN;PHACLOFEN GABA(B) RECEPTOR ANTA;3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;3-amino-2-(4-chlorophenyl)*propanephosphonic acid;(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-;Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-;Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci
CBNumber
CB4272748
Molecular Formula
C9H13ClNO3P
Formula Weight
249.63
MOL File
114012-12-3.mol
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PHACLOFEN Property

Melting point:
249-252 °C
Boiling point:
467.1±55.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
0.1 M HCl: 13.3 mg/mL
form 
solid
pka
1.87±0.10(Predicted)
color 
white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P118
Product name
Phaclofen
Purity
solid
Packaging
5mg
Price
$227
Updated
2025/07/31
Sigma-Aldrich
Product number
P118
Product name
Phaclofen
Purity
solid
Packaging
25mg
Price
$856
Updated
2025/07/31
Sigma-Aldrich
Product number
P118
Product name
Phaclofen
Purity
solid
Packaging
100mg
Price
$2590
Updated
2025/07/31
Usbiological
Product number
256229
Product name
Phaclofen
Packaging
10mg
Price
$389
Updated
2021/12/16
ApexBio Technology
Product number
B6215
Product name
Phaclofen
Packaging
10mg
Price
$218
Updated
2021/12/16
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PHACLOFEN Chemical Properties,Usage,Production

Uses

Phaclofen is a selective GABAB?receptor antagonist.

General Description

Phaclofen is a phosphonic acid derivative of baclofen.

Biological Activity

Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

in vivo

Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus[4].
Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum[5].
Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes[3].

Animal Model:Sprague–Dawley rats (180–250 g)[4]
Dosage:2 mg/kg
Administration:I.p．
Result:Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus.
Animal Model:Male Wistar rats (280–320 g)[5]
Dosage:2 mg/kg
Administration:S.c.
Result:Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.

PHACLOFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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PHACLOFEN Suppliers

China 41 Europe 1 Germany 3 Japan 1 Switzerland 2 United Kingdom 4 United States 10 USA 1 Global 63
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Alexis Corporation
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114012-12-3, PHACLOFENRelated Search:

3-Aminopropylphosphonic acid PHACLOFEN P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE (2-phenylethyl)phosphonic acid

  • 3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID
  • PHACLOFEN
  • (RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID
  • 3-amino-2-(4-chlorophenyl)*propanephosphonic acid
  • PHACLOFEN GABA(B) RECEPTOR ANTA
  • Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-
  • Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-
  • Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci
  • 114012-12-3
  • C9H13CINO3P
  • C9H13ClNO3P
  • GABA/Glycine receptor