PHACLOFEN
- Product Name
- PHACLOFEN
- CAS No.
- 114012-12-3
- Chemical Name
- PHACLOFEN
- Synonyms
- PHACLOFEN;PHACLOFEN GABA(B) RECEPTOR ANTA;3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;3-amino-2-(4-chlorophenyl)*propanephosphonic acid;(RS)-3-AMINO-2-(4-CHLOROPHENYL)PROPYLPHOSPHONIC ACID;Phosphonic acid, (3-amino-2-(4-chlorophenyl)propyl)-;Phosphonic acid, P-[3-amino-2-(4-chlorophenyl)propyl]-;Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicaci
- CBNumber
- CB4272748
- Molecular Formula
- C9H13ClNO3P
- Formula Weight
- 249.63
- MOL File
- 114012-12-3.mol
PHACLOFEN Property
- Melting point:
- 249-252 °C
- Boiling point:
- 467.1±55.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- 0.1 M HCl: 13.3 mg/mL
- form
- solid
- pka
- 1.87±0.10(Predicted)
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P118
- Product name
- Phaclofen
- Purity
- solid
- Packaging
- 5mg
- Price
- $227
- Updated
- 2025/07/31
- Product number
- P118
- Product name
- Phaclofen
- Purity
- solid
- Packaging
- 25mg
- Price
- $856
- Updated
- 2025/07/31
- Product number
- P118
- Product name
- Phaclofen
- Purity
- solid
- Packaging
- 100mg
- Price
- $2590
- Updated
- 2025/07/31
- Product number
- 256229
- Product name
- Phaclofen
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- B6215
- Product name
- Phaclofen
- Packaging
- 10mg
- Price
- $218
- Updated
- 2021/12/16
PHACLOFEN Chemical Properties,Usage,Production
Uses
Phaclofen is a selective GABAB?receptor antagonist.
General Description
Phaclofen is a phosphonic acid derivative of baclofen.
Biological Activity
Selective GABA B antagonist. Phosphono analog of GABA B agonist baclofen ((RS)-4-Amino-3-(4-chlorophenyl)butanoic acid ).
Biochem/physiol Actions
Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (?) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
in vivo
Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus[4].
Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum[5].
Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes[3].
| Animal Model: | Sprague–Dawley rats (180–250 g)[4] |
| Dosage: | 2 mg/kg |
| Administration: | I.p． |
| Result: | Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus. |
| Animal Model: | Male Wistar rats (280–320 g)[5] |
| Dosage: | 2 mg/kg |
| Administration: | S.c. |
| Result: | Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum. |
PHACLOFEN Preparation Products And Raw materials
Raw materials
Preparation Products
PHACLOFEN Suppliers
- Tel
- --
- Fax
- --
- info-tech@nacalai.co.jp
- Country
- Japan
- ProdList
- 6046
- Advantage
- 75