ChemicalBook > CAS DataBase List > tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Product Name
- tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- CAS No.
- 1226781-82-3
- Chemical Name
- tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Synonyms
- CPD0232;MK-3103 Intermediate IV;Omarigliptin Impurity 10;Omarigliptin Intermediate 3;2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-c...;5-Boc-2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole;tert-butyl 2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate;tert-butyl 2-methanesulfonyl-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate;Pyrrolo[3,4-c]pyrazole, 2,4,5,6-tetrahydro-2-(methylsulfonyl)-, benzenesulfonate;tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- CBNumber
- CB42728159
- Molecular Formula
- C11H17N3O4S
- Formula Weight
- 287.34
- MOL File
- 1226781-82-3.mol
More
Less
tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Property
- Boiling point:
- 441.1±55.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.95±0.20(Predicted)
More
Less
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- T204948
- Product name
- tert-Butyl2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0681AP
- Product name
- 2-Methyl-2-propanyl2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate
- Packaging
- 1g
- Price
- $625
- Updated
- 2021/12/16
Chemenu
- Product number
- CM188224
- Product name
- tert-Butyl2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $834
- Updated
- 2021/12/16
Ambeed
- Product number
- A153377
- Product name
- tert-Butyl2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
Chemenu
- Product number
- CM188224
- Product name
- tert-Butyl2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $67
- Updated
- 2021/12/16
More
Less
tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Chemical Properties,Usage,Production
Chemical Properties
white solid
Uses
Tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate is an important organic reagent that can be used as a building block for the synthesis of many organic compounds, such as 2-(methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole. It is an important intermediate of Omarigliptin.
Synthesis
Tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (3.5 g, 16.7 mmol) was dissolved in tetrahydrofuran (35 ml), and sodium hydride (1.0 g, 60%, 25.4 mmol) was added at 0°C, followed by reaction for 30 min. Methylsulfonyl chloride (2.9 g, 25.4 mmol) was added, followed by a reaction for 1 hour. The reaction was quenched by the addition of water (10 ml) to the reaction solution, which was extracted with ethyl acetate (50 ml*2). The organic layers were combined, dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (petroleum ether/ethyl acetate (v/v) = 1:1), to obtain tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate (2.1 g, yield 44%).
tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate Suppliers
- Tel
- 021-20962833 15316628753
- Fax
- 021-2096-2832
- sales@pansopharm.com
- Country
- China
- ProdList
- 611
- Advantage
- 60
- Tel
- 0760-86925768 18824993998
- Fax
- 0760-86925770
- seas168@126.com
- Country
- China
- ProdList
- 60
- Advantage
- 58
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 0512-68311833 13962195826
- Fax
- 0512-68417696
- wuhao@highfine.com
- Country
- China
- ProdList
- 494
- Advantage
- 75
- Tel
- 021-34975603-808 18721111801
- Fax
- +86-21-34975602-805
- sales@bocpharma.com
- Country
- China
- ProdList
- 998
- Advantage
- 64
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 997
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 0574-87365517 18074210286
- Fax
- 87367735
- sales@taikangchem.com
- Country
- China
- ProdList
- 303
- Advantage
- 58
- Tel
- 20-66003216 18666003216
- Fax
- +86-20-28069063
- info@porsefinechemical.com
- Country
- China
- ProdList
- 2353
- Advantage
- 62
- Tel
- 0371-60942985
- Fax
- 0371-60942986,qq1994339443
- Country
- China
- ProdList
- 54
- Advantage
- 58
- Tel
- 0755-89396905
- admin@nexconn.com
- Country
- China
- ProdList
- 299
- Advantage
- 55
- Tel
- 18101936766
- Fax
- 021-58583907
- eileen@shmychem.com
- Country
- China
- ProdList
- 350
- Advantage
- 55
- Tel
- 021-58099077
- Fax
- -
- sales@birdochem.com
- Country
- China
- ProdList
- 185
- Advantage
- 55
- Tel
- 15902145085
- Fax
- -
- 657990292@qq.com
- Country
- China
- ProdList
- 668
- Advantage
- 50
- Tel
- 021-20786057 18918495077
- Fax
- 021-20786057
- 3116390381@qq.com
- Country
- China
- ProdList
- 220
- Advantage
- 58
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 0519-85556809
- Fax
- 0519-85556810
- info@wisdomdrugs.com
- Country
- China
- ProdList
- 213
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 6274
- Advantage
- 58
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 18800375331
- Fax
- 021-50908862
- kangmansales@163.com
- Country
- China
- ProdList
- 7570
- Advantage
- 55
- Tel
- +86 18721201413
- Fax
- +86 (21) 5775-8967
- sales@biopharmaleader.com
- Country
- China
- ProdList
- 1720
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 9839
- Advantage
- 58
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15951
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 15006
- Advantage
- 58
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 18016230971
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 15001988657 15802146997
- info@bookchemicals.com
- Country
- China
- ProdList
- 1004
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 8976
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 7709
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9911
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9976
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- +86 17788583750
- Fax
- +86 571 85220831
- sales@cyanochem.com
- Country
- CHINA
- ProdList
- 281
- Advantage
- 58
- Tel
- 21-33585366
- Fax
- +86-21-34979012
- export01@shyrchem.com
- Country
- CHINA
- ProdList
- 1319
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49476
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 021-58099077-8041 18601625411
- sales@birdotech.com
- Country
- China
- ProdList
- 9493
- Advantage
- 58
- Tel
- 16621358918
- Fax
- QQ:402135374
- botuopharma888@163.com
- Country
- China
- ProdList
- 9208
- Advantage
- 58
- Tel
- 027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4999
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44807
- Advantage
- 58
More
Less
View Lastest Price from tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate 1226781-82-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-02
Career Henan Chemical Co
- Product
- tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate 1226781-82-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30
1226781-82-3, tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylateRelated Search:
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
sacubitril
2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-
AHU-377
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
TICAGRELOR
Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-
Canagliflozin heMihydrate
8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester
Canagliflozin
Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1)
Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 4,6-dihydro-, 1,1-dimethylethyl ester
2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
tert-butyl 1-(2,5-difluorophenyl)-1-oxopent-4-yn-2-ylcarbaMate
CPo3604-01