ChemicalBook > CAS DataBase List > (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Product Name
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
CAS No.
1012341-50-2
Chemical Name
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
Synonyms
(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid;(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84;AHU;sacubitril intermediate;AHU08;4S)-5-([1;LCZ696-24;LCZ696S-01;LCZ696 INT;LCA696 inter
CBNumber
CB62723688
Molecular Formula
C23H29NO4
Formula Weight
383.48
MOL File
1012341-50-2.mol
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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Property

Melting point:
145-147°C
Boiling point:
582.6±50.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
4?+-.0.23(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
InChIKey
YNELJETWNMPEEH-OXDNQSQGNA-N
SMILES
C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |&1:3,6,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B412965
Product name
(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoicAcid
Packaging
5g
Price
$340
Updated
2021/12/16
Matrix Scientific
Product number
153215
Product name
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
Purity
95%
Packaging
5g
Price
$115
Updated
2021/12/16
Chemenu
Product number
CM101918
Product name
(2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid
Purity
95%
Packaging
5g
Price
$281
Updated
2021/12/16
Crysdot
Product number
CD21019730
Product name
(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoicacid
Purity
95+%
Packaging
5g
Price
$297
Updated
2021/12/16
Chemenu
Product number
CM101918
Product name
(2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid
Purity
95%
Packaging
10g
Price
$468
Updated
2021/12/16
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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemical Properties,Usage,Production

Description

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid is a pharmaceutical intermediate compound that can be used to synthesize Sacubitril, a neprilysin inhibitor used as an adjuvant drug in combination with valsartan to reduce the risk of cardiovascular death and heart failure hospitalization in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction.

Uses

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid is a useful building block in the synthesis of various pharmaceuticals. Could be useful for treating bacterial infectious disease.

Synthesis

Dissolve 2g [Ru] catalyst (diiodo(p-cymene) ruthenium(II) dimer) and 1.3g (R,R)-Me-Duphos in 20mL toluene, and react at 65-70 for one hour , Prepared as a chiral catalyst. Add the toluene solution of the above chiral catalyst into a clean hydrogenation kettle, and sequentially add SM1 (763g), 202g triethylamine, and 16L methanol solvent, and then seal the hydrogenation kettle to replace the nitrogen for three times and then replace the hydrogen for three times (0.4-0.5MPa) The reaction was carried out at 55°C for 12 hours under pressure, and the reaction liquid was taken for liquid phase detection. The conversion rate of reaction SM1 reached 99.99%. The reaction solution is filtered and concentrated, and the pure (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid can be obtained by beating with n-hexane and ethyl acetate (1:1); the yield is 96.1%, and the product is an off-white solid.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Suppliers

China 411 India 9 United Kingdom 1 United States 7 Global 428
Zhejiang Jiuzhou Pharmaceutical Co., Ltd
Tel
13566413511
Email
le.sun@jiuzhoupharma.com
Country
China
ProdList
35
Advantage
58
Chiral Quest (Suzhou) Co., Ltd.
Tel
0512-62956066 18112603058
Email
kendoll@cqpharm.com
Country
China
ProdList
96
Advantage
58
Gansu HaoTian Chemical Technology Co., Ltd.
Tel
0943-6900332 17789447501
Fax
0931-8238232
Email
zhuanxiajiang@haotianpharm.com
Country
China
ProdList
192
Advantage
55
Jiangsu Yutian pharmaceutical Co.,Ltd.
Tel
0518-8021621 15062910926
Email
sales@jsytsw.com
Country
China
ProdList
80
Advantage
58
Shandong Sihuan Pharmaceutical Co., Ltd.
Tel
0531-88993893 13335127975
Fax
QQ:787658403
Email
fairouz@sdsihuanpharm.com
Country
China
ProdList
82
Advantage
58
Zhejiang guotuohuanuo pharmatech Co.,Ltd,
Tel
0086-18600013947
Email
prp336019@163.com
Country
China
ProdList
31
Advantage
58
Shanghai Dongyue Biochem Co.,Ltd.
Tel
13512134376
Email
rlzyb@dybiochem.com
Country
China
ProdList
33
Advantage
58
Z IntellecChem& Tech. Co., Ltd
Tel
0511-15050866711; 15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
Country
China
ProdList
101
Advantage
62
Shanghai Peiling Biological Technology Co., Ltd
Tel
13127581762
Email
peilingchem@sina.com
Country
China
ProdList
258
Advantage
58
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
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View Lastest Price from (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-06
Hebei Zhuanglai Chemical Trading Co Ltd
Product
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-09
Hebei Junhua Import and Export Co., LTD
Product
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000
Release date
2025-04-02

1012341-50-2, (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acidRelated Search:

N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester LCZ696 InteMediate (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ Impurity LCZ696 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid Valsartan (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid AHU-377 (heMicalciuM salt) ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester Sacubitril Impurity 72

  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • LCZ696 inter.
  • LCZ-696-001-SS
  • LCZ696-24
  • (2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84
  • (2R, 4S) -5- (biphenyl-4-yl) -4-[(tert-butoxycarbonyl) amino] -2-methylvaleric acid
  • LCZ696S-01
  • AHU08
  • 1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • 4S)-5-([1
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid [DMF No. 031502]
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic aci
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic
  • LCZ696 INT
  • [1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)
  • sacubitril intermediate
  • (2R,4S)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic acid
  • LCA696 inter
  • (2R,4S)-5-(4-Biphenylyl)-2-methyl-4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid
  • AHU
  • (2R, 4S) -5- ([1,1'-]-4- based -4- (biphenyl) (TERT butoxycarbonyl) amino) -2- methyl valerate
  • LCZ-696 Intermediate 40(R,R)
  • 1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)-
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid ISO 9001：2015 REACH
  • LCZ696 intermediates，(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4- ((tert-butoxycarbonyl)amino)-2- methylpentanoic acid
  • Valsartan Impurity 80
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)ami...
  • LCZ696 impurities123
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acidQ: What is (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the CAS Number of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the storage condition of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What are the applications of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
  • the intermidiate of AHU-377
  • Sacubitril-Valsartan Hydrate
  • (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxy
  • LCZ-696 Intermediate 40
  • 2-PYRIMIDINEMETHANOL,7-HYDROXY
  • Propanoicacid,3-cyano-2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(7S)-
  • (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth
  • (αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid
  • (2R,4S)-5-((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
  • Salcubatra calcium impurity 14
  • SACUBITRIL N-BOC ACID (SAV-2)
  • Entresto intermediate N-3
  • LCZ696 Intermediate N-3
  • Sacubitril intermediates (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
  • (2R,4S)-5-([1,1'-biphenyl]-4-y1)-4-((tert-butoxycarbonyl) amino)-2-methylpentanoic acid
  • LCZ696 valsartan + sacubitril Impurity 52
  • (2R,4S)-5-[Biphenyl-4-(tert-butoxycarbonyl)amino]-2-methylpentanoicacid
  • (2R,4S)-5-(4-Biphenylyl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoicacid
  • [1,1'-Biphenyl]-4-pentanoicacid,γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-,(αR,γS)-
  • (αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid
  • (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid - [B15994]
  • (2R,4S)-5-(biphenyl-4-base)-4-[(tert-Butoxycarbonyl)amino ]-2-Methylvaleric acid
  • (2R,4S)-5-(Biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpentanoic acid (Intermediate of Sacubitril Valsartan Sodium)
  • 1012341-50-2
  • 1
  • intermediates
  • intermediate