(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Product Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
CAS No.: 1012341-50-2
Chemical Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
Synonyms: (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid;(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84;AHU;sacubitril intermediate;AHU08;4S)-5-([1;LCZ696-24;LCZ696S-01;LCZ696 INT;LCA696 inter
CBNumber: CB62723688
Molecular Formula: C23H29NO4
Formula Weight: 383.48
MOL File: 1012341-50-2.mol

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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Property

Melting point:: 145-147°C
Boiling point:: 582.6±50.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 4?+-.0.23(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
InChIKey: YNELJETWNMPEEH-OXDNQSQGNA-N
SMILES: C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |&1:3,6,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B412965
Product name: (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoicAcid
Packaging: 5g
Price: $340
Updated: 2021/12/16

Matrix Scientific

Product number: 153215
Product name: (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
Purity: 95%
Packaging: 5g
Price: $115
Updated: 2021/12/16

Chemenu

Product number: CM101918
Product name: (2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid
Purity: 95%
Packaging: 5g
Price: $281
Updated: 2021/12/16

Crysdot

Product number: CD21019730
Product name: (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoicacid
Purity: 95+%
Packaging: 5g
Price: $297
Updated: 2021/12/16

Chemenu

Product number: CM101918
Product name: (2R,4S)-5-([1,1''-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoicacid
Purity: 95%
Packaging: 10g
Price: $468
Updated: 2021/12/16

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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemical Properties,Usage,Production

Description

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid is a pharmaceutical intermediate compound that can be used to synthesize Sacubitril, a neprilysin inhibitor used as an adjuvant drug in combination with valsartan to reduce the risk of cardiovascular death and heart failure hospitalization in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction.

Uses

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid is a useful building block in the synthesis of various pharmaceuticals. Could be useful for treating bacterial infectious disease.

Synthesis

Dissolve 2g [Ru] catalyst (diiodo(p-cymene) ruthenium(II) dimer) and 1.3g (R,R)-Me-Duphos in 20mL toluene, and react at 65-70 for one hour , Prepared as a chiral catalyst. Add the toluene solution of the above chiral catalyst into a clean hydrogenation kettle, and sequentially add SM1 (763g), 202g triethylamine, and 16L methanol solvent, and then seal the hydrogenation kettle to replace the nitrogen for three times and then replace the hydrogen for three times (0.4-0.5MPa) The reaction was carried out at 55°C for 12 hours under pressure, and the reaction liquid was taken for liquid phase detection. The conversion rate of reaction SM1 reached 99.99%. The reaction solution is filtered and concentrated, and the pure (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid can be obtained by beating with n-hexane and ethyl acetate (1:1); the yield is 96.1%, and the product is an off-white solid.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Suppliers

China 389 India 8 United Kingdom 1 United States 7 Global 405

hongqing Huafeng Pharmaceutical Technology Co., LTD

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Chiral Quest (Suzhou) Co., Ltd.

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Jiangsu Vcare PharmaTech Co., Ltd.

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Gansu HaoTian Chemical Technology Co., Ltd.

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CHONGOINGJICHENG BIOPHARMACEUTICAL SCIENCE AND TECHNOLOGY CO.. LTD

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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
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Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
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Nanjing Chemlin Chemical Co., Ltd

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View Lastest Price from (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-09

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-06

Hebei Dangtong Import and export Co LTD

Product: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2
Price: US $130.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 10
Release date: 2023-03-01

1012341-50-2, (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acidRelated Search:

N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester LCZ696 InteMediate (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid LCZ Impurity LCZ696 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid Valsartan (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid AHU-377 (heMicalciuM salt) ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester Sacubitril Impurity 72

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

LCZ696 inter.

LCZ-696-001-SS

LCZ696-24

(2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84

(2R, 4S) -5- (biphenyl-4-yl) -4-[(tert-butoxycarbonyl) amino] -2-methylvaleric acid

LCZ696S-01

AHU08

1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

4S)-5-([1

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid [DMF No. 031502]

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic aci

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)aMino]-2-Methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic

LCZ696 INT

[1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)

sacubitril intermediate

(2R,4S)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pentanoic acid

LCA696 inter

(2R,4S)-5-(4-Biphenylyl)-2-methyl-4-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)pentanoic acid

AHU

(2R, 4S) -5- ([1,1'-]-4- based -4- (biphenyl) (TERT butoxycarbonyl) amino) -2- methyl valerate

LCZ-696 Intermediate 40(R,R)

1,1'-Biphenyl]-4-pentanoic acid, γ-[[(1,1-dimethylethoxy)carbonyl]amino]-α-methyl-, (αR,γS)-

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid ISO 9001：2015 REACH

LCZ696 intermediates，(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4- ((tert-butoxycarbonyl)amino)-2- methylpentanoic acid

Valsartan Impurity 80

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)ami...

LCZ696 impurities123

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acidQ: What is (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the CAS Number of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What is the storage condition of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Q: What are the applications of (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

the intermidiate of AHU-377

Sacubitril-Valsartan Hydrate

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxy

LCZ-696 Intermediate 40

2-PYRIMIDINEMETHANOL,7-HYDROXY

Propanoicacid,3-cyano-2-[[(1,1-dimethylethoxy)carbonyl]amino]-,(7S)-

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth

(αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid

(2R,4S)-5-((2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Salcubatra calcium impurity 14

SACUBITRIL N-BOC ACID (SAV-2)

Entresto intermediate N-3

LCZ696 Intermediate N-3

Sacubitril intermediates (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-y1)-4-((tert-butoxycarbonyl) amino)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

(αR,γS)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl[1,1'-biphenyl]-4-pentanoic acid

LCZ696 valsartan + sacubitril Impurity 52

1012341-50-2

1

intermediates

intermediate

LCZ696

032-LCZ696

1012341-50-2