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AHU-377 (heMicalciuM salt)

Product Name
AHU-377 (heMicalciuM salt)
CAS No.
1369773-39-6
Chemical Name
AHU-377 (heMicalciuM salt)
Synonyms
Sacubitril Calcium;Sacubitril hemicalcium;Sacubitril calcium salt;(alphar;LCZ696-1;Sacubitril ca;Sabatrol calcium;AHU377 Calcium Salt;AHU-377 Hemicalcium;Sacubitrial Calcium
CBNumber
CB72685916
Molecular Formula
C48H56CaN2O10
Formula Weight
861.04364
MOL File
1369773-39-6.mol
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AHU-377 (heMicalciuM salt) Property

Melting point:
>140°C (dec.)
Density 
1.24g/cm3 at 20℃
vapor pressure 
0.001Pa at 20℃
storage temp. 
-20°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
powder
color 
white to beige
optical activity
-16.3°(C=0.01g/mL,MEOH, 20°C, 589nm)
InChIKey
DDLCKLBRBPYKQS-AGIGYYLVNA-L
LogP
-0.66-2.9 at 20℃ and pH2-7
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Safety

RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1380
Product name
Sacubitril calcium salt
Purity
≥98% (HPLC)
Packaging
5MG
Price
$124
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1380
Product name
Sacubitril calcium salt
Purity
≥98% (HPLC)
Packaging
25MG
Price
$438.9
Updated
2025/07/31
Cayman Chemical
Product number
21473
Product name
AHU377 (calcium salt)
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
21473
Product name
AHU377 (calcium salt)
Purity
≥98%
Packaging
25mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
21473
Product name
AHU377 (calcium salt)
Purity
≥98%
Packaging
50mg
Price
$219
Updated
2024/03/01
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AHU-377 (heMicalciuM salt) Chemical Properties,Usage,Production

Uses

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

in vivo

In humans, Sacubitril (AHU-377)(tmax 0.5-1.1 h) are absorbed quickly. Sacubitril hemicalcium salt is converted rapidly into LBQ657 with its tmax being reached in 1.9-3.5 h. Mean t1/2 values for the biologically active LBQ657 is 9.9-11.1 h[2].In vehicle-treated dogs, ANF increases urinary sodium excretion from 17.3±3.6 to 199.5±18.4 pequivkglmin. This effect is potentiated significantly in animals which receive Sacubitril (AHU-377). Urinary volume is also potentiated in animals which receive an iv administration of Sacubitril (AHU-377)[1].

storage

Store at -20°C

AHU-377 (heMicalciuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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AHU-377 (heMicalciuM salt) Suppliers

China 290 India 11 United Kingdom 1 United States 14 Global 316
Changzhou Yuanda Pharmaceutical Chemical Co., Ltd.
Tel
0519-83984084
Fax
0519-88776993
Email
sales@ydpharm.com
Country
China
ProdList
119
Advantage
60
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518 13327700685
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
308
Advantage
61
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Shanghai Scientia Pharmaceutical Technology Co., Ltd.
Tel
21-21-54301573 13917723525
Fax
(86)21-51861981
Email
sales@scientiapharm.com
Country
China
ProdList
263
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258 13912342323;
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
294
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
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View Lastest Price from AHU-377 (heMicalciuM salt) manufacturers

Watson Biotechnology Co.,Ltd
Product
AHU-377 1369773-39-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2025-02-18
Shaanxi Dideu New Materials Co. Ltd
Product
AHU-377 (heMicalciuM salt) 1369773-39-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-05
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Ahu-377 Hemicalcium Salt 1369773-39-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-09-19

1369773-39-6, AHU-377 (heMicalciuM salt)Related Search:

Sacubitril-(2R,4R)-Isomer Sacubitril - D4 AHU-377 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride LCZ696 (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid LCZ696 interMediate (2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one Sacubitril Impurity 72 (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate sacubitril Valsartan (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Sacubitril Calcium

  • AHU-377 (heMicalciuM salt)
  • (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
  • (2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)
  • AHU-377 hemicalcium salt (2:1)
  • Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate)
  • LCZ696(valsartan + sacubitril) impurity 1
  • Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
  • (alphar
  • 1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
  • gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1
  • LCZ696-1
  • monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate)
  • Sacubitril Calcium
  • Sacubitril Hemicalcium salt
  • (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
  • Sacubitril calcium salt
  • [1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
  • (alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt
  • Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
  • (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt)
  • AHU377 Calcium Salt
  • AHU-377 Hemicalcium
  • LCZ696 Impurity 534-06
  • (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal
  • LCZ696 intermediates，AHU-377 (heMicalciuM salt)
  • Sacubitril hemicalcium
  • (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-m...
  • SACUBITRIL-13C4 CALCIUM
  • Sacubitril-d5 Calcium Salt
  • Sacubitril 13C4 CalciumQ: What is Sacubitril 13C4 Calcium Q: What is the CAS Number of Sacubitril 13C4 Calcium
  • LCZ-696 Impurity 29 calcium salt
  • Ethyl (2R,4S)-5-(Biphenyl-4-yl)-4-(amino)-5-(3-carboxypropionyl)amino]-2-methylpentanoate, calcium salt
  • Calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
  • Calcium 4-((2S,4R)-1-(biphenyl-4-yl) -5-ethoxy-4-methyl-5-oxopentan-2-ylamino)-4-oxobutanoate
  • Sacubitril calcium salt（AHU-377 ）
  • Sacubitril Calcium Salt CRS
  • Sacubitrol calcium salt
  • (2R, 4S) -5- (biphenyl-4-yl) -4- (amino) -5- (3-carboxy-propionylamino-2-methyl-ventrate ethyl ester calcium salt
  • Sacubitrial Calcium
  • LCZ 696 hemicalcium salt
  • LCZ696 hemicalcium salt
  • (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
  • Sabatrol calcium
  • 1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
  • Sacubitril Valsartan Sodium (LCZ696)
  • Sacubitril hemicalcium salt, 10 mM in DMSO
  • Calcium(2R,4S)-ethyl5-(4-biphenylyl)-4-amino-2-methyl-5-(3-carboxypropanoylamino)pentanoate
  • Sacubitril hemicalcium salt/AHU-377
  • Sacubitril ca
  • (αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
  • Calcium 4-((2S,4R)-1-(biphenyl-4-yl) -5-ethoxy-4-methyl-5-oxopentan-2-ylamino)-4-oxobutanoate (Intermediate of Sacubitril Valsartan Sodium)
  • Sacubitril hemicalciium salt
  • 1369773-39-6
  • C48H56CaN2O10
  • 2C24H29NO5Ca
  • Intermediates
  • LCZ 696
  • Pharmaceutical Intermediates