(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Property

Density 

1.50±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: soluble15mg/mL (clear solution)

pka

11.95±0.46(Predicted)

form 

powder

color 

white to beige

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 3 months.

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Chemical Properties,Usage,Production

Description

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 1.18 μM) over an isogenic control cell line (EC₅₀ = 27.6 μM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways. It is stable in saline and modestly stable in human plasma.

Uses

ML-239, is an inhibitor of breast cancer stem cells, with greater than 23 fold selectivity of inhibition in the cell line.

Definition

ChEBI: N'-(2-pyrrolylidenemethyl)-2-(2,4,6-trichlorophenoxy)acetohydrazide is an aromatic ether.

storage

Store at +4°C

References

1) Carmody et al. (2012), Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells; J. Biomol. Screening, 17 1204 2) Germain et al. (2012), Identification of a selective small molecule inhibitor of breast cancer stem cells; Bioorg. Med. Chem., 22 3571 3) Rees et al. (2015), Correlating chemical sensitivity and basal gene expression reveals mechanism of action; Nat. Chem. Biol. 12 109