ML365

Product Name: ML365
CAS No.: 947914-18-3
Chemical Name: ML365
Synonyms: ML365;CS-2437;ML365, 10 mM in DMSO;ML-365; ML365; ML 365;2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide;2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide;Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-;KcsA,aldosterone,diseases,Inhibitor,autoimmune,channels,ML365,secretion,TASK,ML-365,potassium,Potassium Channel,TWIK-related,pharmacological,acid-sensitive,hypertension,inhibit,ML 365,CNS,tool
CBNumber: CB92715655
Molecular Formula: C22H20N2O3
Formula Weight: 360.41
MOL File: 947914-18-3.mol

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ML365 Property

Boiling point:: 429.9±40.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:72.0(Max Conc. mg/mL);199.77(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM)
form: Powder
pka: 13.21±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 25mg
Price: $442
Updated: 2024/03/01

Tocris

Product number: 5337
Product name: ML365
Purity: ≥99%(HPLC)
Packaging: 50
Price: $770
Updated: 2021/12/16

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ML365 Chemical Properties,Usage,Production

Uses

ML 365 acts as a potent and selective ASK-1 potassium channel blocker used in the regulation of cell membrane potential. This activity further modulates cell immune response, hormone changes, and neuronal function leading to various applications.

Biological Activity

Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, Emax = 3.82% of Glu Emax; r at mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (r at TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (r at TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.

storage

Store at +4°C

ML365 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML365 Suppliers

China 65 United Kingdom 1 United States 11 Global 77

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19185
Advantage: 64

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1004
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9987
Advantage: 58

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View Lastest Price from ML365 manufacturers

Career Henan Chemical Co

Product: ML365 947914-18-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

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ML365

2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide

ML-365; ML365; ML 365

2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

CS-2437

Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-

KcsA,aldosterone,diseases,Inhibitor,autoimmune,channels,ML365,secretion,TASK,ML-365,potassium,Potassium Channel,TWIK-related,pharmacological,acid-sensitive,hypertension,inhibit,ML 365,CNS,tool

ML365, 10 mM in DMSO

947914-18-3

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