M348

Product Name: M348
CAS No.: 899713-86-1
Chemical Name: M348
Synonyms: M348;ML348;CS-2370;GNF-Pf-1127;ML348 ，S6564;ML-348 (ML348);ML 348;GNF-PF-1127;ML348, 10 mM in DMSO;APT1 Inhibitor II, Cpd21;alpha-synuclein 1-95, human
CBNumber: CB53147505
Molecular Formula: C18H17ClF3N3O3
Formula Weight: 415.79
MOL File: 899713-86-1.mol

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M348 Property

Boiling point:: 546.2±50.0 °C(Predicted)
Density: 1.422±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form: Powder
pka: 13.13±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1901
Product name: ML348
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $102.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1901
Product name: ML348
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $436
Updated: 2025/07/31

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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M348 Chemical Properties,Usage,Production

Uses

ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

in vivo

ML348 (50 mg/kg, i.p., 3 hours) shows potent and selective activity in vivo, inhibits LYPLA1 enzymes in heart, kidney and lung in mice^[1].

Animal Model:	C57BL6 male mice (3-4 months)^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 3 hours
Result:	Potent and selective inhibited LYPLA1 enzymes in heart, kidney and lung in vivo.

storage

Store at +4°C

M348 Preparation Products And Raw materials

Raw materials

Preparation Products

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M348 Suppliers

China 97 India 1 United Kingdom 1 United States 11 USA 1 Global 111

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
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Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
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Shanghaizehan biopharma technology co., Ltd.

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Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

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Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

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Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
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Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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899713-86-1