M348

Product Name: M348
CAS No.: 899713-86-1
Chemical Name: M348
Synonyms: M348;ML348;CS-2370;GNF-Pf-1127;ML-348 (ML348);ML 348;GNF-PF-1127;alpha-synuclein 1-95, human;ML 348,Phospholipase,ML348,ML-348,inhibit,Inhibitor;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
CBNumber: CB53147505
Molecular Formula: C18H17ClF3N3O3
Formula Weight: 415.79
MOL File: 899713-86-1.mol

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M348 Property

Boiling point:: 546.2±50.0 °C(Predicted)
Density: 1.422±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form: Powder
pka: 13.13±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1901
Product name: ML348
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1901
Product name: ML348
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2024/03/01

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 18523
Product name: ML348
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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M348 Chemical Properties,Usage,Production

Uses

ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

storage

Store at +4°C

M348 Preparation Products And Raw materials

Raw materials

Preparation Products

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M348 Suppliers

China 73 India 1 United Kingdom 1 United States 11 USA 1 Global 87

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1009
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 8026
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4602
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2992
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

899713-86-1, M348Related Search:

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N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide

CS-2370

M348

ML348

ML-348 (ML348)

GNF-Pf-1127

ML 348;GNF-PF-1127

1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-

alpha-synuclein 1-95, human

ML 348,Phospholipase,ML348,ML-348,inhibit,Inhibitor

N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide

899713-86-1