ChemicalBook > CAS DataBase List > ML365

ML365

Product Name: ML365
CAS No.: 947914-18-3
Chemical Name: ML365
Synonyms: ML365;CS-2437;ML365, 10 mM in DMSO;ML-365; ML365; ML 365;2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide;2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide;Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-;2-Methoxy-N-(3-(3-methylbenzcarboxcarboxcarboxamido)phenyl)-benzamide;KcsA,aldosterone,diseases,Inhibitor,autoimmune,channels,ML365,secretion,TASK,ML-365,potassium,Potassium Channel,TWIK-related,pharmacological,acid-sensitive,hypertension,inhibit,ML 365,CNS,tool
CBNumber: CB92715655
Molecular Formula: C22H20N2O3
Formula Weight: 360.41
MOL File: 947914-18-3.mol

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ML365 Property

Boiling point:: 429.9±40.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO:72.0(Max Conc. mg/mL);199.77(Max Conc. mM)
Ethanol:18.0(Max Conc. mg/mL);49.94(Max Conc. mM)
form: Powder
pka: 13.21±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2643
Product name: ML365
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $96.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2643
Product name: ML365
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $387
Updated: 2025/07/31

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24666
Product name: ML-365
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

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ML365 Chemical Properties,Usage,Production

Uses

ML 365 acts as a potent and selective ASK-1 potassium channel blocker used in the regulation of cell membrane potential. This activity further modulates cell immune response, hormone changes, and neuronal function leading to various applications.

Biological Activity

Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, Emax = 3.82% of Glu Emax; r at mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (r at TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (r at TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.

storage

Store at +4°C

ML365 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ML365 manufacturers

Career Henan Chemical Co

Product: ML365 947914-18-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

947914-18-3, ML365Related Search:

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ML365

2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide

ML-365; ML365; ML 365

2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

CS-2437

Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-

KcsA,aldosterone,diseases,Inhibitor,autoimmune,channels,ML365,secretion,TASK,ML-365,potassium,Potassium Channel,TWIK-related,pharmacological,acid-sensitive,hypertension,inhibit,ML 365,CNS,tool

ML365, 10 mM in DMSO

2-Methoxy-N-(3-(3-methylbenzcarboxcarboxcarboxamido)phenyl)-benzamide

947914-18-3

API