ChemicalBook > CAS DataBase List > 6-Nitroveratraldehyde

6-Nitroveratraldehyde

Product Name
6-Nitroveratraldehyde
CAS No.
20357-25-9
Chemical Name
6-Nitroveratraldehyde
Synonyms
DMNB;NVAD;NVAD20357-25-9;ASISCHEM R27925;DNA-K Inhibitor;6-nitroveratrol;DNA-PK Inhibitor;TIMTEC-BB SBB000505;DMNB, 10 mM in DMSO;6-NITROVERATRALDEHYDE
CBNumber
CB4275729
Molecular Formula
C9H9NO5
Formula Weight
211.17
MOL File
20357-25-9.mol
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6-Nitroveratraldehyde Property

Melting point:
131-133 °C (lit.)
Boiling point:
350.84°C (rough estimate)
Density 
1.4194 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO: 22 mg/mL
form 
solid
color 
yellow
Water Solubility 
Insoluble in water. Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO.
Sensitive 
Air & Light Sensitive
BRN 
395599
CAS DataBase Reference
20357-25-9(CAS DataBase Reference)
NIST Chemistry Reference
6-Nitroveratraldehyde(20357-25-9)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
RTECS 
GY8410000
HazardClass 
IRRITANT
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
279609
Product name
6-Nitroveratraldehyde
Purity
technical grade, 80%
Packaging
5g
Price
$50.2
Updated
2024/03/01
Sigma-Aldrich
Product number
260960
Product name
DNA-PK Inhibitor
Packaging
10mg
Price
$130
Updated
2024/03/01
TCI Chemical
Product number
N0538
Product name
6-Nitroveratraldehyde
Purity
>85.0%(GC)
Packaging
5g
Price
$112
Updated
2024/03/01
TCI Chemical
Product number
N0538
Product name
6-Nitroveratraldehyde
Purity
>85.0%(GC)
Packaging
25g
Price
$447
Updated
2024/03/01
Alfa Aesar
Product number
A14415
Product name
6-Nitroveratraldehyde, 96%
Packaging
5g
Price
$57.3
Updated
2024/03/01
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6-Nitroveratraldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow fluffy powder

Uses

6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.

Definition

ChEBI: 4,5-dimethoxy-2-nitrobenzaldehyde is a C-nitro compound and an aromatic ether.

General Description

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.

Biological Activity

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

Biochem/physiol Actions

Cell permeable: yes

Purification Methods

The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]

6-Nitroveratraldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Nitroveratraldehyde manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
6-Nitroveratraldehyde 20357-25-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Shaanxi Dideu New Materials Co. Ltd
Product
6-Nitroveratraldehyde 20357-25-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000KG
Release date
2024-11-09
Henan Fengda Chemical Co., Ltd
Product
6-Nitroveratraldehyde 20357-25-9
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25

20357-25-9, 6-Nitroveratraldehyde Related Search:

4-Dimethylaminobenzaldehyde Dimethyldimethoxysilane 3,5-Dimethoxybenzaldehyde 2,6-Dimethoxybenzaldehyde 3,4-Dimethoxybenzoic acid 2-Nitrobenzaldehyde 2,5-Dimethoxybenzaldehyde Dimethoxymethane p-Anisaldehyde 3-Phenoxybenzaldehyde 2,4-Dimethoxybenzaldehyde Veratraldehyde 2,3-Dimethoxybenzaldehyde o-Anisaldehyde NITROGEN DIOXIDE 2,6-DINITROPHENOL VERATRINE Methyl 2-nitro-3,4,5-trimethoxybenzoate

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