2,4,6-TRIHYDROXYBENZALDEHYDE

Product Name: 2,4,6-TRIHYDROXYBENZALDEHYDE
CAS No.: 487-70-7
Chemical Name: 2,4,6-TRIHYDROXYBENZALDEHYDE
Synonyms: formylphloroglucinal;NSC 38610;Formylphloroglucinol;Phlorogluchnaldehyde;PHLOROGLUCINALDEHYDE;Guaiacol Impurity 15;PHLOROGLUCINOL ALDEHYDE;Benserazide Impurity 18;PHLOROGLUCINOLCARBOXALDEHYDE;2,4,6-trihydroxy-benzaldehyd
CBNumber: CB4284583
Molecular Formula: C7H6O4
Formula Weight: 154.12
MOL File: 487-70-7.mol

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2,4,6-TRIHYDROXYBENZALDEHYDE Property

Melting point:: 195 °C (dec.)(lit.)
Boiling point:: 237.46°C (rough estimate)
Density: 1.3725 (rough estimate)
refractive index: 1.6400 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightlly, Heated)
form: Solid
pka: 7.37±0.23(Predicted)
color: Orange to Dark Orange
Water Solubility: Soluble in water.
Sensitive: Air Sensitive
BRN: 2254429
InChIKey: BTQAJGSMXCDDAJ-UHFFFAOYSA-N
LogP: 1.370 (est)
CAS DataBase Reference: 487-70-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: CU8440000
HS Code: 29124990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T65404
Product name: 2,4,6-Trihydroxybenzaldehyde
Purity: ≥97%
Packaging: 5g
Price: $203
Updated: 2025/07/31

TCI Chemical

Product number: T1744
Product name: 2,4,6-Trihydroxybenzaldehyde
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $104
Updated: 2025/07/31

TRC

Product number: T795170
Product name: 2,4,6-Trihydroxybenzaldehyde
Packaging: 10g
Price: $165
Updated: 2021/12/16

TRC

Product number: T795170
Product name: 2,4,6-Trihydroxybenzaldehyde
Packaging: 25g
Price: $265
Updated: 2021/12/16

TRC

Product number: T795170
Product name: 2,4,6-Trihydroxybenzaldehyde
Packaging: 1g
Price: $65
Updated: 2021/12/16

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2,4,6-TRIHYDROXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

pale pink crystalline powder

Uses

Reactant involved in the synthesis of biologically active molecules including:• ;2,4,6-trichlorophenyl hydrazones with potential inhibition of protein glycation1• ;Esculentoside A derivatives with haemolytic activity and LPS-induced nitric oxide production inhibition2• ;α-Nucleophiles for hydrolysis of organophosphorus nerve agents3• ;Xanthine oxidase inhibitors4• ;Non-complexes Schiff base hydrazones5• ;Methylated (±)-epigallocatechin gallate library for anticancer activity studies6

Uses

2,4,6-Trihydroxybenzaldehyde is a reactant involved in the synthesis of 2,4,6-trichlorophenyl hydrazones with potential inhibition of protein glycation and Xanthine oxidase inhibitors.

Definition

ChEBI: 2,4,6-trihydroxybenzaldehyde is a carboxylic ester. It is functionally related to a phloroglucinol.

Synthesis

108-73-6

68-12-2

487-70-7

To a solution of ethyl acetate (20 ml) containing resorcinol (1.9 g, 15 mmol), N,N-dimethylformamide (1.26 ml, 16.5 mmol) and trichlorophosphorus (1.5 ml, 16.5 mmol) were sequentially added at 0°C under ice bath conditions. After removing the ice bath, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, water was added and the mixture was refluxed for 30 minutes. After the reaction solution was cooled to room temperature, it was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel fast column chromatography (petroleum ether-ethyl acetate, 4:1) to give resorcinol formaldehyde (2.12 g, 92% yield) as a white solid. The product was characterized by 1H NMR (500 MHz, DMSO-d6) and 13C NMR (126 MHz, DMSO-d6) with the following data: 1H NMR δ 9.92 (s, 1H), 5.78 (s, 2H); 13C NMR δ 191.4, 167.6, 164.5, 105.0, 94.6.

in vivo

2,4,6-Trihydroxybenzaldehyde (oral administration; 5 and 25 mg/kg for 13 weeks) reduces the HFD-induced increase in weight gain, reduces serum levels of glucose, triglycerides, and total cholesterol^[1].

References

[1] Organic Letters, 2015, vol. 17, # 16, p. 4110 - 4113
[2] Tetrahedron Letters, 2016, vol. 57, # 17, p. 1856 - 1859
[3] Synthetic Communications, 1998, vol. 28, # 15, p. 2861 - 2869
[4] Organic Letters, 2010, vol. 12, # 8, p. 1676 - 1679
[5] Synlett, 2007, # 1, p. 129 - 130

2,4,6-TRIHYDROXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4,6-TRIHYDROXYBENZALDEHYDE Suppliers

China 168 France 1 Germany 2 India 11 Italy 2 Japan 2 Slovakia 1 Switzerland 3 The Netherlands 1 United Kingdom 16 United States 21 USA 1 Global 229

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View Lastest Price from 2,4,6-TRIHYDROXYBENZALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,4,6-Trihydroxybenzaldehyde 487-70-7
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-29

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2,4,6-Trihydroxybenzaldehyde 487-70-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4,6-Trihydroxybenzaldehyde 487-70-7
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

487-70-7, 2,4,6-TRIHYDROXYBENZALDEHYDERelated Search:

2',4',6'-Trihydroxyacetophenone monohydrate Phloretin Myricetin 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE 5,7-Dihydrox -4'-methoxyisoflavone Rutin 2-HYDROXY-4,6-DIMETHOXYBENZOIC ACID Quercetin Chrysin 2,3',4,4',6-Pentahydroxybenzophenone 2,4,6-TRIHYDROXYBENZALDEHYDE Naringenin 2,4,6-Trimethoxybenzaldehyde Flopropione Phlorizin 2,4,6-Trihydroxybenzoic acid METHYL 2,4,6-TRIHYDROXYBENZOATE STERIGMATOCYSTIN

2,4,6-TRIHYDROXYBENZALDEHYDE

2,4,6-trihydroxy-benzaldehyd

Benzaldehyde, 2,4,6-trihydroxy-

formylphloroglucinal

Formylphloroglucinol

PHLOROGLUCINOL ALDEHYDE

PHLOROGLUCINALDEHYDE

PHLOROGLUCINOLCARBOXALDEHYDE

Phlorogluchnaldehyde

2,4,6-TRIHYDROXYBENZALDEHYDE 98+%

2,4,6-Trihydroxybenzaldehyde,95%

2,4,6-Trihydroxybenzaldehyde,97%

PHLOROGLUCINOL ALDEHYDE TRIETHYLETHER(RG)

NSC 38610

Benserazide Impurity 18

Guaiacol Impurity 15

2,4,6-Trihydroxybenzaldehyde, 10 mM in DMSO

487-70-7

C7H6O42H2O

HO3C6H2CHO

ALDEHYDE

Aldehydes

Organic Building Blocks

Building Blocks

Carbonyl Compounds

C7

Aldehydes

Building Blocks

C7

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aromatic Aldehydes & Derivatives (substituted)