2',4',6'-Trihydroxyacetophenone monohydrate
- Product Name
- 2',4',6'-Trihydroxyacetophenone monohydrate
- CAS No.
- 480-66-0
- Chemical Name
- 2',4',6'-Trihydroxyacetophenone monohydrate
- Synonyms
- THAP;Phloracetophenone;PHLOROACETOPHENONE;Monoacetylphloroglucinol;2-Acetylphloroglucinol hydrate;2',4',6'-TRIHYDROXYACETOPHENONE;2,4,6-trihydroxylacetophenone monohydrate;NSC 54927;Phloracetophene;Acetophloroglucine
- CBNumber
- CB2333652
- Molecular Formula
- C8H8O4
- Formula Weight
- 168.15
- MOL File
- 480-66-0.mol
2',4',6'-Trihydroxyacetophenone monohydrate Property
- Melting point:
- 219-221 °C(lit.)
- Boiling point:
- 257.07°C (rough estimate)
- Density
- 1.3037 (rough estimate)
- refractive index
- 1.5090 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly), Water (Very Slightly,
- pka
- 7.76±0.23(Predicted)
- form
- Powder
- color
- light yellow
- Water Solubility
- Soluble in water.
- BRN
- 1911197
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- LogP
- 1.472 (est)
- CAS DataBase Reference
- 480-66-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0)
- EPA Substance Registry System
- Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- RTECS
- AN0528000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29145000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T1888
- Product name
- 2',4',6'-Trihydroxyacetophenone Monohydrate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $79
- Updated
- 2024/03/01
- Product number
- T1888
- Product name
- 2',4',6'-Trihydroxyacetophenone Monohydrate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $244
- Updated
- 2024/03/01
- Product number
- L04156
- Product name
- 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
- Packaging
- 5g
- Price
- $39.65
- Updated
- 2024/03/01
- Product number
- L04156
- Product name
- 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
- Packaging
- 25g
- Price
- $110.65
- Updated
- 2024/03/01
- Product number
- 19451
- Product name
- Monoacetylphloroglucinol
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $49
- Updated
- 2021/12/16
2',4',6'-Trihydroxyacetophenone monohydrate Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
Monoacetylphloroglucinol (MAPG) is small molecular weight phenolic metabolite belonging to the phloroglucinol (1,3,5-trihydroxybenzene) family, produced by bacteria including Pseudomonas strains. MAPG exhibits a broad range of biological activity albeit with mostly low potency. In the search for novel actives, MAPG and related metabolites are important metabolites for dereplication to eliminate leads due to high amounts of weakly potent actives. Although weakly active, this family appears to be important in the biocontrol of plant diseases by some Pseudomonas strains.
Uses
Induced choleresis in rats is mediated through multidrug resistance protein-2 (Mrp2). It enhances bile secretion.
Definition
ChEBI: A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acid c glycans and glycopeptides.
Preparation
Preparation by reaction of acetic anhydride on phloroglucinol,
with concentrated sulfuric acid at 130° (70%)
with boron trifluoride at 10° (62.5–68%)
with zinc chloride at 145–150° (50%)
with Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) at 160° (39%).
Biological Activity
monoacetylphloroglucinol (mapg), small molecular weight phenolic metabolite, is produced via bacteria including pseudomonas strains. mapg is acetylated to form the broad-spectrum antibiotic, 2,4-diacetylphloroglucinol (dapg) by mapg acetyltransferase. in addition, mapg exerts fairly weak potency when exhibiting a broad range of antibiotic activity. even though weakly active, it seems that mapg is essential in the biocontrol of plant diseases by some pseudomonas strains [1].
target
HMG-CoA Reductase
Purification Methods
Crystallise the ketone from hot H2O (35mL/g). [Beilstein 8 IV 2729.]
References
[1]. hayashi, a., saitou, h., mori, t., matano, i., sugisaki, h., & maruyama, k. molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase frompseudomonassp. ygj3. bioscience, biotechnology, and biochemistry. 2012; 76(3): 559-566.
2',4',6'-Trihydroxyacetophenone monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2',4',6'-Trihydroxyacetophenone monohydrate manufacturers
- Product
- 2-Acetylphloroglucinol hydrate 480-66-0
- Price
- US $1.00-100.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 300KG
- Release date
- 2024-08-19
- Product
- 2',4',6'-Trihydroxyacetophenone monohydrate 480-66-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2023-02-22
- Product
- 2',4',6'-Trihydroxyacetophenone 480-66-0
- Price
- US $650.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-01