2',4',6'-Trihydroxyacetophenone monohydrate

Product Name: 2',4',6'-Trihydroxyacetophenone monohydrate
CAS No.: 480-66-0
Chemical Name: 2',4',6'-Trihydroxyacetophenone monohydrate
Synonyms: THAP;Phloracetophenone;PHLOROACETOPHENONE;Monoacetylphloroglucinol;2-Acetylphloroglucinol hydrate;2',4',6'-TRIHYDROXYACETOPHENONE;2,4,6-trihydroxylacetophenone monohydrate;NSC 54927;Phloracetophene;Acetophloroglucine
CBNumber: CB2333652
Molecular Formula: C8H8O4
Formula Weight: 168.15
MOL File: 480-66-0.mol

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2',4',6'-Trihydroxyacetophenone monohydrate Property

Melting point:: 219-221 °C(lit.)
Boiling point:: 257.07°C (rough estimate)
Density: 1.3037 (rough estimate)
refractive index: 1.5090 (estimate)
storage temp.: Store below +30°C.
solubility: DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly), Water (Very Slightly,
pka: 7.76±0.23(Predicted)
form: Powder
color: light yellow
Water Solubility: Soluble in water.
BRN: 1911197
Stability:: Stable under recommended storage conditions., Stable Under Recommended Storage C
LogP: 1.472 (est)
CAS DataBase Reference: 480-66-0(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(2,4,6-trihydroxyphenyl)-(480-66-0)
EPA Substance Registry System: Ethanone, 1-(2,4,6-trihydroxyphenyl)- (480-66-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
RTECS: AN0528000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29145000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T1888
Product name: 2',4',6'-Trihydroxyacetophenone Monohydrate
Purity: >98.0%(GC)
Packaging: 5g
Price: $79
Updated: 2024/03/01

TCI Chemical

Product number: T1888
Product name: 2',4',6'-Trihydroxyacetophenone Monohydrate
Purity: >98.0%(GC)
Packaging: 25g
Price: $244
Updated: 2024/03/01

Alfa Aesar

Product number: L04156
Product name: 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
Packaging: 5g
Price: $39.65
Updated: 2024/03/01

Alfa Aesar

Product number: L04156
Product name: 2',4',6'-Trihydroxyacetophenone hydrate, 98+%
Packaging: 25g
Price: $110.65
Updated: 2024/03/01

Cayman Chemical

Product number: 19451
Product name: Monoacetylphloroglucinol
Purity: ≥98%
Packaging: 10g
Price: $49
Updated: 2021/12/16

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2',4',6'-Trihydroxyacetophenone monohydrate Chemical Properties,Usage,Production

Chemical Properties

Light Brown Solid

Uses

Monoacetylphloroglucinol (MAPG) is small molecular weight phenolic metabolite belonging to the phloroglucinol (1,3,5-trihydroxybenzene) family, produced by bacteria including Pseudomonas strains. MAPG exhibits a broad range of biological activity albeit with mostly low potency. In the search for novel actives, MAPG and related metabolites are important metabolites for dereplication to eliminate leads due to high amounts of weakly potent actives. Although weakly active, this family appears to be important in the biocontrol of plant diseases by some Pseudomonas strains.

Uses

Induced choleresis in rats is mediated through multidrug resistance protein-2 (Mrp2). It enhances bile secretion.

Definition

ChEBI: A benzenetriol that is acetophenone in which the hydrogens at positions 2, 4, and 6 on the phenyl group are replaced by hydroxy groups. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of acid c glycans and glycopeptides.

Preparation

Preparation by reaction of acetic anhydride on phloroglucinol,
with concentrated sulfuric acid at 130° (70%)
with boron trifluoride at 10° (62.5–68%)
with zinc chloride at 145–150° (50%)
with Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) at 160° (39%).

Biological Activity

monoacetylphloroglucinol (mapg), small molecular weight phenolic metabolite, is produced via bacteria including pseudomonas strains. mapg is acetylated to form the broad-spectrum antibiotic, 2,4-diacetylphloroglucinol (dapg) by mapg acetyltransferase. in addition, mapg exerts fairly weak potency when exhibiting a broad range of antibiotic activity. even though weakly active, it seems that mapg is essential in the biocontrol of plant diseases by some pseudomonas strains [1].

target

HMG-CoA Reductase

Purification Methods

Crystallise the ketone from hot H2O (35mL/g). [Beilstein 8 IV 2729.]

References

[1]. hayashi, a., saitou, h., mori, t., matano, i., sugisaki, h., & maruyama, k. molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase frompseudomonassp. ygj3. bioscience, biotechnology, and biochemistry. 2012; 76(3): 559-566.

2',4',6'-Trihydroxyacetophenone monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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2',4',6'-Trihydroxyacetophenone monohydrate Suppliers

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View Lastest Price from 2',4',6'-Trihydroxyacetophenone monohydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Acetylphloroglucinol hydrate 480-66-0
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 300KG
Release date: 2024-08-19

Hebei Weibang Biotechnology Co., Ltd

Product: 2',4',6'-Trihydroxyacetophenone monohydrate 480-66-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2023-02-22

R&D Scientific Inc.

Product: 2',4',6'-Trihydroxyacetophenone 480-66-0
Price: US $650.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-04-01

480-66-0, 2',4',6'-Trihydroxyacetophenone monohydrateRelated Search:

Acetophenone MELIBIOSE 3,5-Dihydroxyacetophenone 2-HYDROXYACETOPHENONE 2',6'-Dihydroxyacetophenone 3'-Hydroxyacetophenone 2,4-Dihydroxyacetophenone 4-Nitroacetophenone 4'-(Trifluoromethyl)acetophenone 3-Aminoacetophenone 4'-Hydroxyacetophenone 3,4-Dihydroxyacetophenone 2'-Hydroxyacetophenone 4'-Bromoacetophenone 2',4'-Dichloroacetophenone 3-Nitroacetophenone Chloral hydrate Rutin

2',4',6'-Trihydroxyacetophenone monohydrate

2-Acetylphloroglucinol hydrate

Phloroacetophenone monohydrate

THAP

2',4',6'-Trihydroxyacetophenone (monohydrate/anhydrous)

2',4',6'-Trihydroxyacetophenone hydrate, 98+%

1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE

2',4',6'-TRIHYDROXYACETOPHENONE

Acetophenone,2’,4’,6’-trihydroxy-

Acetophloroglucine

Acetylphloroglucinol

Ethanone,1-(2,4,6-trihydroxyphenyl)-

Phloracetophene

Phloracetophenone

Phloroacetophenonehydrate

PHLOROACETOPHENONE

2,4,6-TRIHYDROXYACETOPHENONE(PHLOROACETOPHENONE)

2,4,6-Trihydroxyaetcophenone

2,4,6-TRIHYDROXYACETOPHENONE MONOHYDRATE, PGE. WITH 10X10 MG

2,4,6-TRIHYDROXYLACETOPHENONE

6'-Trihydroxyacetophenone

2-(2,4-dihydroxyphenyl)-2-hydroxy-1-phenylethanone

JR-13799, 1-(2,4,6-Trihydroxyphenyl)ethanone hydrate, 98%

NSC 54927

2',4',6'-Trihydroxyacetophenone,98%

2-Acetylphloroglucinol, THAP

1-(2,4,6-tTihydroxyphenyl)ethanone

2,4,6-Trihydroxy-1-acetylbenzene

Methyl-(2,4,6-trihydroxyphenyl) ketone

2',4',6'-Trihydroxya

1-(2,4,6-Trihydroxyphenyl)ethan-1-one, 2-Acetylbenzene-1,3,5-triol

1-(2,4-dihydroxyphenyl)-2-hydroxyethan-1-one

2-Acetylphloroglucinol Phloroacetophenone

1-(2,4,6-trihydroxyphenyl)ethanone hydrate

2',4', 6'-Trihydroxyacetophenone Monohydrat

2',4',6'-trihydroxyacetopheMone

Monoacetylphloroglucinol

Acetophenone, 2',4',6'-trihydroxy- (8CI)

2,4,6-Trihydroxyacetophenone.H2O

1-(2,4,6-trihydroxyphenyl)-ethanon

2,4,6-Trihydroxyacetophenon

2,4,6-TrihydroxyacetophenonMonohydrat

2,4,6-trihyroxyacetophenone

2-Acetyl-1,3,5-trihydroxybenzene

2-Acetylphloroglucin

Acetophenone, 2',4',6'-trihydroxy-

2',4',67-TRIHYDROXYACETOPHENONE MONOHYDR

Phloroglucinol Acetyl

2,4,6-trihydroxylacetophenone monohydrate

Phloracetophenone/2',4',6'-Trihydroxyacetophenone

1-(2,4,6-trihydroxyphenyl)ethan-1-one

2',4',6'-Trihydroxyacetophenone

2',4',6'-Trihydroxyacetophenon

2’,4’,6’-Trihydroxyacetophenone-98%

480-66-0

C8H8O4xH2O

HO3C6H2COCH3H2O

Ketones