Ibandronate sodium monohydrate

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Ibandronate sodium monohydrate

Product Name: Ibandronate sodium monohydrate
CAS No.: 138926-19-9
Chemical Name: Ibandronate sodium monohydrate
Synonyms: Boniva;Bonviva;Ibandrate;BM-21.0955;RPR-102289A;Ibronate Sodium;Ibadronate SodiuM;Ibandronate sodium;Boniva monohydrate;Bondronat monohydrate
CBNumber: CB4286017
Molecular Formula: C9H24NNaO8P2
Formula Weight: 359.23
MOL File: 138926-19-9.mol

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Ibandronate sodium monohydrate Property

Melting point:: 840C (dec)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Soluble in DMSO (up to at least 25 mg/ml)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 138926-19-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 40
Safety Statements: 22-36-24/25
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21361
Product name: Ibandronate (sodium hydrate)
Purity: ≥95%
Packaging: 25mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 21361
Product name: Ibandronate (sodium hydrate)
Purity: ≥95%
Packaging: 50mg
Price: $76
Updated: 2024/03/01

Cayman Chemical

Product number: 21361
Product name: Ibandronate (sodium hydrate)
Purity: ≥95%
Packaging: 100mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 21361
Product name: Ibandronate (sodium hydrate)
Purity: ≥95%
Packaging: 250mg
Price: $312
Updated: 2024/03/01

Usbiological

Product number: 280375
Product name: Ibandronate sodium monohydrate
Packaging: 5g
Price: $337
Updated: 2021/12/16

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Ibandronate sodium monohydrate Chemical Properties,Usage,Production

Description

Ibandronate Sodium Monohydrate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.
Ibandronate Sodium Monohydrate inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's. Ibandronate Sodium Monohydrate is an inhibitor of FDPS.

Chemical Properties

[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt is White Crystalline Powder

Uses

Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as asteoporosis, metastatic disease, and Paget d

Uses

bone resorption inhibitor, anthypercalcemic

Uses

An inhibitor of bone resorption

Mechanism of action

The action of ibandronate on bone tissue is based on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Ibandronate inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Pharmacokinetics

Absorption
The absorption of oral ibandronate occurs in the upper gastrointestinal tract. Plasma concentrations increase in a dose-linear manner up to 50 mg oral intake and increases nonlinearly above this dose.
Following oral dosing, the time to maximum observed plasma ibandronate concentrations ranged from 0.5 to 2 hours (median 1 hour) in fasted healthy postmenopausal women. The mean oral bioavailability of 2.5 mg ibandronate was about 0.6% compared to intravenous dosing. The extent of absorption is impaired by food or beverages (other than plain water). The oral bioavailability of ibandronate is reduced by about 90% when BONIVA is administered concomitantly with a standard breakfast in comparison with bioavailability observed in fasted subjects. There is no meaningful reduction in bioavailability when ibandronate is taken at least 60 minutes before a meal. However, both bioavailability and the effect on bone mineral density (BMD) are reduced when food or beverages are taken less than 60 minutes following an ibandronate dose.
Distribution
After absorption, ibandronate either rapidly binds to bone or is excreted into urine. In humans, the apparent terminal volume of distribution is at least 90 L, and the amount of dose removed from the circulation via the bone is estimated to be 40% to 50% of the circulating dose. In vitro protein binding in human serum was 99.5% to 90.9% over an ibandronate concentration range of 2 to 10 ng/mL in one study and approximately 85.7% over a concentration range of 0.5 to 10 ng/mL in another study.
Metabolism
There is no evidence that ibandronate is metabolized in humans.
https://www.accessdata.fda.gov

References

1) Russell (2006), Ibandronate: Pharmacology and preclinical studies; Bone 38 S7

Ibandronate sodium monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ibandronate sodium monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ibandronate sodium monohydrate 138926-19-9
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%-102%
Supply Ability: 100kg
Release date: 2021-09-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ibandronate sodium 138926-19-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Shaanxi Dideu Medichem Co. Ltd

Product: Ibandronate Sodium 138926-19-9
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-16

138926-19-9, Ibandronate sodium monohydrateRelated Search:

Pamidronic acid b-Alanine, N-methyl-N-pentyl- Ibandronate Impurity 1(Ibandronate EP Impurity B) Alendronate sodium Letrozole 3,5-Bis(2-cyanoprop-2-yl)toluene INTERMEDIATE OF IBANDRONATE SODIUM N-Pentyl-β-alanine ETHYLENEDIAMINETETRAACETIC ACID TRIPOTASSIUM SALT DIHYDRATE Disodium edetate dihydrate N-DesMethyl Ibandronate SodiuM Olpadronate Sodium Ibandronate Sodium Anhydrous N-Methylpentylamine Acryloyl chloride Trisodium phosphate methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate Tetramethyl Ibandronate

Ibandrate

Ibandromate Monosodium

Sodium Trihydrogen (1-Hydroxy-3-(methylpenthylamino)propylidene)diphosphonate Monohydrate

BM-21.0955

Boniva

Bonviva

IBANDRONATE SODIUM/1-HYDROXY-3-(METHYLPENTYLAMINO)PROPYLIDENE

Ibadronate SodiuM

Ibandronate Sodium (100 mg)

{1-hydroxy-3-[Methyl(pentyl)aMino]-1-phosphonopropyl}phosphonic acid

IBANDRONATE SODIUM MONOHYDRATE

1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonatemonosodiummonohydrate

[1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt

Ibandronate sodium

IBANDRONATE SODIUM SALT

Ibandronate sodiuM salt Monhydrate

Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)

Ibandronate Sodium (200 mg)

Ibandronate Sodium Hydrate

Ibandronate sodium monohydrate, >=99%

Bondronat monohydrate

Boniva monohydrate

RPR-102289A

Ibronate Sodium

[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic acid sodium salt monohydrate

Ibandronate Sodium MonohydrateQ: What is Ibandronate Sodium Monohydrate Q: What is the CAS Number of Ibandronate Sodium Monohydrate Q: What is the storage condition of Ibandronate Sodium Monohydrate Q: What are the applications of Ibandronate Sodium Monohydrate

Ibandronate Sodium (1335417)

138926-19-9

38926-19-9

C9H23NO7P2NaH2O

C9H24NO8NaP2

C9H24NNaO8P2

C9H22NO7P2Na

C9H22O7NP2NaH2O

C9H22NO7P2NaH2O

C9H22NNaO7P2H2O

C9H22O7NP2Na

C9H22NO7P2H2ONa

Inhibitors

BONIVA

Intermediates & Fine Chemicals

Pharmaceuticals

API's

Ibandronate

anti-osteoporosis

Bone resorption inhibitor