ChemicalBook > CAS DataBase List > 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE

Product Name: 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE
CAS No.: 3171-45-7
Chemical Name: 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE
Synonyms: 4,5-DIMETHYL-1,2-PHENYLENEDIAMINE;4,5-Dimethyl-1,2-benzenediamine;4,5-DIMETHYL-BENZENE-1,2-DIAMINE;4,5-Dimethyl-ortho-phenylenediamine;4,5-DimethyL;4,5-DIAMINO-O-XYLENE;4-flouro-2-nitro aniline;Methylcobalamin Impurity 1;2-AMINO-4,5-DIMETHYLANILINE;4,5-Dimethyl-2-amino-aniline
CBNumber: CB4292911
Molecular Formula: C8H12N2
Formula Weight: 136.19
MOL File: 3171-45-7.mol

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4,6-DIMETHYL-1,2-PHENYLENEDIAMINE Property

Melting point:: 127-129 °C (lit.)
Boiling point:: 279.6±35.0 °C(Predicted)
Density: 1.076±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.02±0.10(Predicted)
form: Crystalline Mass, Crystals or Chunks
color: White to yellow to brownish
Water Solubility: Slightly soluble in water.
Sensitive: Air & Light Sensitive
InChI: InChI=1S/C8H12N2/c1-5-3-7(9)8(10)4-6(5)2/h3-4H,9-10H2,1-2H3
InChIKey: XSZYBMMYQCYIPC-UHFFFAOYSA-N
SMILES: C1(N)=CC(C)=C(C)C=C1N
CAS DataBase Reference: 3171-45-7(CAS DataBase Reference)
EPA Substance Registry System: 1,2-Benzenediamine, 4,5-dimethyl- (3171-45-7)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-36
Safety Statements: 26-36
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29212900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D176605
Product name: 4,5-Dimethyl-1,2-phenylenediamine
Purity: 98%
Packaging: 5g
Price: $120
Updated: 2025/07/31

Sigma-Aldrich

Product number: D176605
Product name: 4,5-Dimethyl-1,2-phenylenediamine
Purity: 98%
Packaging: 25g
Price: $194
Updated: 2025/07/31

TCI Chemical

Product number: D1083
Product name: 4,5-Dimethyl-1,2-phenylenediamine
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: D1083
Product name: 4,5-Dimethyl-1,2-phenylenediamine
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $225
Updated: 2025/07/31

TRC

Product number: D476755
Product name: 4,5-Dimethyl-o-phenylenediamine
Packaging: 100g
Price: $580
Updated: 2021/12/16

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4,6-DIMETHYL-1,2-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

4, 5-dimethyl-o-phenylenediamine used in the determination of aromatic aldehydes by high performance liquid chromatography after precolumn fluorescent derivatization. For the determination of vanillin.

Uses

Employed in the preparation of transition metal complexes1 and quinoxalinones.2

Synthesis Reference(s)

Tetrahedron Letters, 42, p. 2277, 2001 DOI: 10.1016/S0040-4039(01)00163-0

Synthesis

6972-71-0

3171-45-7

(4.1) The reducing system was prepared by adding 32 mL of deionized water to 72 mL of anhydrous ethanol solution containing 12.9 g (57.17 mmol; 9.5 eq.) of SnCl2-2H2O. Subsequently, 1 g (6.02 mmol; 1 eq.) of 4,5-dimethyl-2-nitroaniline was added in batches at room temperature and under inert atmosphere. The reaction mixture was heated to reflux for 1 h. The reaction process was monitored by thin layer chromatography (TLC) (unfolding agent: ethyl acetate). After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into 120 mL of water and neutralized with NaHCO3. The tin salts and NaHCO3 were removed by filtration through filter paper. the filtrate was extracted with dichloromethane (organic phase 1) and the residual solid was continuously extracted with dichloromethane through a Soxhlet extractor for 2 days. The dichloromethane phase after Soxhlet extraction was washed once with water (organic phase 2). Organic phases 1 and 2 were combined, dried over anhydrous MgSO4, filtered and concentrated. The crude product was purified by silica gel fast column chromatography (elution gradient: cyclohexane/ethyl acetate 2/8; pure ethyl acetate; ethyl acetate/methanol 95/5). The resulting target compound (No. cs 357-1) was an orange solid in quantitative yield. rf = 0.33 (ethyl acetate). 1H NMR (CDCl3, ppm): 2.12 (s, 6H, 2 x CH3); 6.52 (s, 2H, 2 x aromatic CH). 13C NMR (CDCl3, ppm): 18.99 (CH3); 118.64 (aromatic CH); 128.02 (quaternary carbon-CH3); 132.38 (quaternary carbon-N). Mass spectrum (MS): [M + H]+ m/z = 137.1; [M + Na]+ m/z = 159.1; [M + K]+ m/z = 175.2.

References

[1] Patent: WO2011/117830, 2011, A1. Location in patent: Page/Page column 20
[2] Chemistry - A European Journal, 2018, vol. 24, # 36, p. 8989 - 8993
[3] ChemCatChem, 2016, vol. 8, # 15, p. 2461 - 2465
[4] Biochemische Zeitschrift, 1956, vol. 327, p. 422,447
[5] Chemische Berichte, 1901, vol. 34, p. 2255

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Stannous chloride dihydrate Ethanol Diethyl ether Nitric acid Sodium hydroxide 3,4-Dimethylaniline Sulfuric acid

Preparation Products

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View Lastest Price from 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE 3171-45-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-09

Shanghai UCHEM Inc.

Product: 4,5-Dimethyl-1,2-phenylenediamine 3171-45-7
Price: US $30.00-296.00/g
Min. Order: 25g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-04

Shaanxi Dideu Medichem Co. Ltd

Product: 4,5-Dimethyl-1,2-benzenediamine 3171-45-7
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-08

3171-45-7, 4,6-DIMETHYL-1,2-PHENYLENEDIAMINERelated Search:

RIBOFLAVINE TETRABUTYRATE 4,6-DIMETHYL-1,2-PHENYLENEDIAMINE 5,6-DIMETHYL-2-BENZIMIDAZOLINONE 4,5-DIMETHYL-2-NITROPHENYL ISOCYANATE Riboflavin 5'-Monophosphate Sodium Salt 4,5-DIMETHYL-2-NITROANILINE Pendimethalin FLAVIN ADENINE DINUCLEOTIDE N,N’-BISACETYLACETO-2,5-DIMETHYL-1,4-PHENYLENEDIAMINE LUMIFLAVINE N N-DIMETHYL-1 4-PHENYLENEDIAMINE SULFA& N,N-DIMETHYL-1,4-PHENYLENEDIAMINE OXALATE N,N-DIMETHYL-1,3-PHENYLENEDIAMINE DIHYDROCHLORIDE N,N-DIMETHYL-1,4-PHENYLENEDIAMINE SULFATE N,N-DIMETHYL-1,4-PHENYLENEDIAMINE DIAZONIUM CHLORIDE ZINC CHLORIDE N,N-DIMETHYL-P-PHENYLENEDIAMINE MONOHYDROCHLORIDE N,N-DIMETHYL-1,4-PHENYLENEDIAMINE Riboflavin

1,2-Benzenediamine, 4,5-dimethyl-

4,5-Dimethyl-1,2-benzenediamine

4,5-Dimethyl-1,2-diaminobenzene

4,5-Dimethyl-1,2-phenylenediamine 98%

4,5-Dimethyl-ortho-phenylenediamine

4,5-bis(methyl-d3)benzene-1,2-diamine

4,5-Dimethylbenzene-1,2-diamine 98%

4,5-dimethyl-2-benzenediamine

2-AMINO-4,5-DIMETHYLPHENYLAMINE

2-AMINO-4,5-DIMETHYLANILINE

4,5-DIAMINO-O-XYLENE

4,5-DIAMINO-1,2-DIMETHYLBENZENE

4,5-DIMETHYL-O-PHENYLENE DIAMINE

4,5-DIMETHYL-1,2-PHENYLENEDIAMINE

4,5-DIMETHYL-BENZENE-1,2-DIAMINE

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE

1,2-DIMETHYL-4,5-DIAMINOBENZENE

4,5-DIMETHYL-1,2-PHENYLENEDIAMINE 95+%

1,2-DIAMINO-4,5-DIMETHYLBENZENE

1,2-DiaMino-4,5-diMethylbenzene[4,5-DiMethyl-1,2-phenylenediaMine]

4,5-Dimethyl-1,2-phenylenediamine,4,5-Diamino-o-xylene

4,5-Dimethyl-1,2-phenylenediamine >95.0%(T)

4,5-DiMethyl-o-phenylenediaMine Monohydrate, 98%

4,5-Diamino-o-xylene, 4,5-Dimethylphenylene-1,2-diamine

4,5-Dimethylbenzene-1,2-diamine 98+%

Methylcobalamin Impurity 1

4,5-Dimethyl-1,2-phenylenediamine &gt

4,5-Dimethyl-1,2-phenylenediamine, 95%, for synthesis

4,5-DimethyL

4,6-DIMETHYL-1,2-PHENYLENEDIAMINE ISO 9001：2015 REACH

4-flouro-2-nitro aniline

Cyanocobalamin /Vitamin B12 Impurity 17

4,5-Dimethyl-2-amino-aniline

3171-45-7

CH32C6H2NH22

AMINE

Organic Building Blocks

Nitrogen Compounds

Polyamines

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Polyamines

Anilines, Aromatic Amines and Nitro Compounds

intermediate