ChemicalBook > CAS DataBase List > 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID

Product Name
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
CAS No.
5653-46-3
Chemical Name
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
Synonyms
NSC 37414;AKOS 244-33;VERATRIC ACID, 2-HYDROXY-;3,4-DIMETHOXYSALICYLIC ACID;2-Hydroxy-3,4-dimethoxybenzoic;3,4-DIMETHOXYSALICYLIC ACID 97%;3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID;2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID;HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-;2-HYDROXY-3,4-DIMETHOXYBENZOICCID 97%
CBNumber
CB4301279
Molecular Formula
C9H10O5
Formula Weight
198.17
MOL File
5653-46-3.mol
More
Less

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Property

Melting point:
170-172℃
Boiling point:
334℃
Density 
1.335
Flash point:
134℃
storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
color 
White to off-white
LogP
2.070 (est)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
250mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
500mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
1g
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0036288
Product name
2-Hydroxy-3,4-dimethoxybenzoicacid
Packaging
100mg
Price
$204
Updated
2021/12/16
More
Less

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Chemical Properties,Usage,Production

Uses

2-Hydroxy-3,4-dimethoxybenzoic acid (3,4-Dimethoxysalicylic acid) is an olefinic benzene derivative[1].

Definition

ChEBI: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID is a methoxybenzoic acid.

Synthesis

573-11-5

5653-46-3

General procedure for the synthesis of 2-hydroxy-3,4-dimethoxybenzoic acid (3-B) from 2,3,4-trimethoxybenzoic acid (3-A):[04081] 1. 2,3,4-trimethoxybenzoic acid (3-A) (1.06 g, 5 mmol) was dissolved in dichloromethane (DCM) (30 mL) at -20 °C. 2. Boron tribromide (BBr3) (0.5 mL, 5.5 mmol) was slowly added to the above solution, keeping the reaction temperature at -20 °C. 3. The reaction mixture was stirred continuously for 30 minutes at -20°C. 4. 4. Upon completion of the reaction, sodium bicarbonate (NaHCO3) was added to quench the reaction. 5. 2N hydrochloric acid (HCl) (50mL) was added followed by extraction with dichloromethane (DCM). 6. The organic layer was separated and concentrated to give the target product 2-hydroxy-3,4-dimethoxybenzoic acid (3-B) (705 mg, 62.2% yield).

References

[1] Solheim E, et al. Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers[J]. Xenobiotica, 1976, 6(3): 137-150. DOI:10.3109/00498257609151624

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Suppliers

China 53 France 1 Germany 2 India 2 Switzerland 1 United Kingdom 5 United States 10 USA 1 Global 75
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
BePharm Ltd
Tel
400-685-9117
Fax
021-51816740
Email
market@bepharm.com
Country
China
ProdList
15081
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Guangzhou Ruixinkang Chemical Products Co., Ltd.
Tel
18027422796
Email
2329783215@qq.com
Country
CHINA
ProdList
132
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-029-81024372 17792795018
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10003
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
ChemeGen
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Fuzhou Fukang Pharmaceutical Technology Co., Ltd.
Tel
18150835816
Email
120023275@qq.com
Country
China
ProdList
593
Advantage
58
AAB-PHARMA LIMITED
Tel
02566880956
Email
3325708371@qq.com
Country
China
ProdList
7869
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Shanghai Yanbang Pharmaceutical Technology Co., Ltd
Tel
15618536883
Email
1228181347@qq.com
Country
China
ProdList
7951
Advantage
58
Zhuhai Aobokai Biomedical Technology Co., Ltd.
Tel
400-0628126
Email
sales-team@aobchem.com.cn
Country
China
ProdList
50000
Advantage
58
Anhui Henuo Biotechnology Co., Ltd
Tel
18455579438
Country
China
ProdList
16684
Advantage
58
Z-trans Biochemistry Technology (Suzhou) Co.,Ltd
Tel
0512-66317708 13372112871
Email
huijuan@zitrans.cn
Country
China
ProdList
1993
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
rose.shi@synzest.com
Country
China
ProdList
6210
Advantage
58
Hubei Hengluyuan Technology co.ltd
Tel
027-88188016 18717196322
Email
1764683941@qq.com
Country
China
ProdList
6356
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Ningbo Chaoming Biotechnology Co., Ltd
Tel
13301662590
Email
mandy@atkchemical.com
Country
China
ProdList
9343
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Email
sales@coreychem.com
Country
China
ProdList
29847
Advantage
58
Shanghai Zheyan Biotech Co., Ltd.
Tel
18017610038
Email
zheyansh@163.com
Country
CHINA
ProdList
3619
Advantage
58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
Email
cooperation@kean-chem.com
Country
China
ProdList
40066
Advantage
58
Jilin Chinese Academy of Sciences-yanshen Technology
Tel
+undefined18143011203
Email
info@chemextension.com
Country
China
ProdList
42056
Advantage
58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+86-18621343501; +undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33338
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49941
Advantage
58
Aromsyn Co., Ltd.
Tel
+86-0571-85585865 +8613336024896
Email
CB@aromsyn.com
Country
China
ProdList
19183
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
--
Fax
--
Email
sales@sunwaypharm.com
Country
China
ProdList
6536
Advantage
58
ChemiK Co., Ltd.
Tel
+86 574 8729 6330
Fax
+86 574 8729 7461
Email
info@chemik.com
Country
China
ProdList
3616
Advantage
61
Biorbyt Ltd.
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6482
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Carbosynth China Ltd.
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
China
ProdList
6532
Advantage
50
Excenen Pharmatech Co., Ltd
Tel
--
Fax
--
Email
contact@excenen.com
Country
China
ProdList
261
Advantage
60
More
Less

View Lastest Price from 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
2-hydroxy-3,4-dimethoxybenzoic acid 5653-46-3
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

5653-46-3, 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACIDRelated Search:

5-HYDROXY-3,4-DIMETHOXYBENZOIC ACID,5-HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 98+%,5-Hydroxy-3,4-dimethoxybenzoic acid, 97+%,3-HYDROXY-4,5-DIMETHOXYBENZOIC ACID 4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester 2,3,4-Trimethoxybenzoic acid 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID 4-Hydroxy-3,5-Dimethoxybenzoic Acid Methyl Ester Syringic acid 2-HYDROXY-4,6-DIMETHOXYBENZOIC ACID Reserpic acid, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl carbonate 3,4-Dimethoxybenzoic acid 5-(CHLOROSULFONYL)-2,3,4-TRIMETHOXYBENZOIC ACID LEIOCARPOSIDE MONOCERIN 4-Hydroxy-2,6-dimethoxybenzoic acid methyl ester 2-Hydroxy-3,5-dimethoxybenzoic acid Benzoic acid-3-hydroxy-4,5-dimethoxy- methyl ester 3-Hydroxy-4,5-dimethoxybenzoic acid [dodecahydro-11-oxo-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-2-yl] ester HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-(RG) 2-Hydroxy-4,6-dimethoxybenzoic acid methyl ester

  • 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
  • 3,4-DIMETHOXYSALICYLIC ACID
  • 3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID
  • HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-
  • 2-Hydroxy-3,4-dimethoxybenzoic
  • AKOS 244-33
  • 2-HYDROXY-3,4-DIMETHOXYBENZOICCID 97%
  • Benzoic acid, 2-hydroxy-3,4-dimethoxy-
  • VERATRIC ACID, 2-HYDROXY-
  • 3,4-DIMETHOXYSALICYLIC ACID 97%
  • 3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID 97%
  • NSC 37414
  • 2HYDROXY3,4DIMETHOXYBENZOIC ACID,2 HYDROXY 3,4 DIMETHOXYBENZOIC ACID
  • 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 10 mM in DMSO
  • 5653-46-3
  • CH3O2C6H2OHCOOH
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts