ChemicalBook > CAS DataBase List > 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID

Product Name
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
CAS No.
5653-46-3
Chemical Name
2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
Synonyms
NSC 37414;AKOS 244-33;VERATRIC ACID, 2-HYDROXY-;3,4-DIMETHOXYSALICYLIC ACID;2-Hydroxy-3,4-dimethoxybenzoic;3,4-DIMETHOXYSALICYLIC ACID 97%;3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID;2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID;HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-;2-HYDROXY-3,4-DIMETHOXYBENZOICCID 97%
CBNumber
CB4301279
Molecular Formula
C9H10O5
Formula Weight
198.17
MOL File
5653-46-3.mol
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2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Property

Melting point:
170-172℃
Boiling point:
334℃
Density 
1.335
Flash point:
134℃
storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
color 
White to off-white
LogP
2.070 (est)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
250mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
500mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD70162
Product name
3,4-Dimethoxy-2-hydroxybenzoic acid
Packaging
1g
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0036288
Product name
2-Hydroxy-3,4-dimethoxybenzoicacid
Packaging
100mg
Price
$204
Updated
2021/12/16
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2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Chemical Properties,Usage,Production

Uses

2-Hydroxy-3,4-dimethoxybenzoic acid (3,4-Dimethoxysalicylic acid) is an olefinic benzene derivative[1].

Definition

ChEBI: 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID is a methoxybenzoic acid.

Synthesis

573-11-5

5653-46-3

General procedure for the synthesis of 2-hydroxy-3,4-dimethoxybenzoic acid (3-B) from 2,3,4-trimethoxybenzoic acid (3-A):[04081] 1. 2,3,4-trimethoxybenzoic acid (3-A) (1.06 g, 5 mmol) was dissolved in dichloromethane (DCM) (30 mL) at -20 °C. 2. Boron tribromide (BBr3) (0.5 mL, 5.5 mmol) was slowly added to the above solution, keeping the reaction temperature at -20 °C. 3. The reaction mixture was stirred continuously for 30 minutes at -20°C. 4. 4. Upon completion of the reaction, sodium bicarbonate (NaHCO3) was added to quench the reaction. 5. 2N hydrochloric acid (HCl) (50mL) was added followed by extraction with dichloromethane (DCM). 6. The organic layer was separated and concentrated to give the target product 2-hydroxy-3,4-dimethoxybenzoic acid (3-B) (705 mg, 62.2% yield).

References

[1] Solheim E, et al. Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers[J]. Xenobiotica, 1976, 6(3): 137-150. DOI:10.3109/00498257609151624

2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID Suppliers

China 53 France 1 Germany 2 India 2 Switzerland 1 United Kingdom 5 United States 10 USA 1 Global 75
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View Lastest Price from 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
2-hydroxy-3,4-dimethoxybenzoic acid 5653-46-3
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

5653-46-3, 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACIDRelated Search:

5-HYDROXY-3,4-DIMETHOXYBENZOIC ACID,5-HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 98+%,5-Hydroxy-3,4-dimethoxybenzoic acid, 97+%,3-HYDROXY-4,5-DIMETHOXYBENZOIC ACID 4-Hydroxy-3,5-dimethoxybenzoic acid 4-guanidinobutyl ester 2,3,4-Trimethoxybenzoic acid 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID 4-Hydroxy-3,5-Dimethoxybenzoic Acid Methyl Ester Syringic acid 2-HYDROXY-4,6-DIMETHOXYBENZOIC ACID Reserpic acid, methyl ester, ester with 4-hydroxy-3,5-dimethoxybenzoic acid ethyl carbonate 3,4-Dimethoxybenzoic acid 5-(CHLOROSULFONYL)-2,3,4-TRIMETHOXYBENZOIC ACID LEIOCARPOSIDE MONOCERIN 4-Hydroxy-2,6-dimethoxybenzoic acid methyl ester 2-Hydroxy-3,5-dimethoxybenzoic acid Benzoic acid-3-hydroxy-4,5-dimethoxy- methyl ester 3-Hydroxy-4,5-dimethoxybenzoic acid [dodecahydro-11-oxo-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-2-yl] ester HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-(RG) 2-Hydroxy-4,6-dimethoxybenzoic acid methyl ester

  • 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID
  • 3,4-DIMETHOXYSALICYLIC ACID
  • 3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID
  • HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 2-
  • 2-Hydroxy-3,4-dimethoxybenzoic
  • AKOS 244-33
  • 2-HYDROXY-3,4-DIMETHOXYBENZOICCID 97%
  • Benzoic acid, 2-hydroxy-3,4-dimethoxy-
  • VERATRIC ACID, 2-HYDROXY-
  • 3,4-DIMETHOXYSALICYLIC ACID 97%
  • 3,4-DIMETHOXY-2-HYDROXYBENZOIC ACID 97%
  • NSC 37414
  • 2HYDROXY3,4DIMETHOXYBENZOIC ACID,2 HYDROXY 3,4 DIMETHOXYBENZOIC ACID
  • 2-HYDROXY-3,4-DIMETHOXYBENZOIC ACID, 10 mM in DMSO
  • 5653-46-3
  • CH3O2C6H2OHCOOH
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts