ChemicalBook > CAS DataBase List > 2,2-Dimethyl-1,3-dioxolane-4-methanol

2,2-Dimethyl-1,3-dioxolane-4-methanol

Product Name
2,2-Dimethyl-1,3-dioxolane-4-methanol
CAS No.
100-79-8
Chemical Name
2,2-Dimethyl-1,3-dioxolane-4-methanol
Synonyms
Glycerol acetonide;ISOPROPYLIDENEGLYCEROL;2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL;isopropylidene;glycerolacetonide;AUGEO;1,2-ISOPROPYLIDENEGLYCEROL;GIE;ideneg;idenegL
CBNumber
CB4305646
Molecular Formula
C6H12O3
Formula Weight
132.16
MOL File
100-79-8.mol
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2,2-Dimethyl-1,3-dioxolane-4-methanol Property

Melting point:
-27℃
Boiling point:
189-191 °C
Density 
1.066 g/mL at 20 °C(lit.)
vapor pressure 
34Pa at 20℃
refractive index 
n20/D 1.434
Flash point:
176 °F
storage temp. 
Sealed in dry,2-8°C
solubility 
172g/l soluble
form 
Liquid
pka
14.20±0.10(Predicted)
color 
Clear colorless
PH
4.0-7.5 (H2O)
optical activity
4.1°(C=1.00 g/100mL, ETOH, 20°C, 589nm)
Water Solubility 
miscible
Merck 
14,5213
BRN 
104465
InChIKey
RNVYQYLELCKWAN-UHFFFAOYSA-N
LogP
0.3 at 20℃
CAS DataBase Reference
100-79-8(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dioxolane-4-methanol, 2,2-dimethyl-(100-79-8)
EPA Substance Registry System
1,3-Dioxolane-4-methanol, 2,2-dimethyl- (100-79-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-36-26
WGK Germany 
2
RTECS 
JI0400000
F 
10
TSCA 
Yes
HS Code 
29329970
Toxicity
LD50 in rats (g/kg): 7 orally; 3 i.p. (Perez)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
122696
Product name
DL-1,2-Isopropylideneglycerol
Purity
≥97.0%
Packaging
100g
Price
$42.9
Updated
2025/07/31
Sigma-Aldrich
Product number
122696
Product name
DL-1,2-Isopropylideneglycerol
Purity
≥97.0%
Packaging
3kg
Price
$355
Updated
2025/07/31
TCI Chemical
Product number
D0710
Product name
2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity
>98.0%(GC)
Packaging
25g
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
D0710
Product name
2,2-Dimethyl-1,3-dioxolane-4-methanol
Purity
>98.0%(GC)
Packaging
100g
Price
$95
Updated
2025/07/31
Sigma-Aldrich
Product number
122696
Product name
DL-1,2-Isopropylideneglycerol
Purity
≥97.0%
Packaging
500g
Price
$87.7
Updated
2025/07/31
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2,2-Dimethyl-1,3-dioxolane-4-methanol Chemical Properties,Usage,Production

Chemical Properties

clear colourless liquid

Uses

Solketal is useful for synthesis of mono-, di- and triglycerides. It is used as the starting reagent for synthesis of tulipaline derivatives. It acts as a fuel additive in gasoline. It is an inhibitor of Methyl ethyl ketone .

Uses

DL-1,2-Isopropylideneglycerol was used as the starting reagent for synthesis of tulipaline derivatives.

Uses

A MEK inhibitor

Synthesis Reference(s)

Tetrahedron, 52, p. 9387, 1996 DOI: 10.1016/0040-4020(96)00501-7
The Journal of Organic Chemistry, 53, p. 2859, 1988 DOI: 10.1021/jo00247a043

General Description

DL-1,2-Isopropylideneglycerol undergoes effective isopropylidenation and deprotection reaction catalyzed by phosphotungstic acid.

Safety Profile

A poison by intravenous route. An eye irritant. Mutation data reported. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.

2,2-Dimethyl-1,3-dioxolane-4-methanol Preparation Products And Raw materials

Raw materials

Glycerol HYDROGEN CYANIDE

Preparation Products

2,3-DIHYDROXYPROPYL METHACRYLATE BENZYL GLYCIDYL ETHER 3-ETHOXY-1,2-PROPANEDIOL 2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Dropropizine
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2,2-Dimethyl-1,3-dioxolane-4-methanol Suppliers

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View Lastest Price from 2,2-Dimethyl-1,3-dioxolane-4-methanol manufacturers

Weifang Integratechem Co., Ltd.
Product
2,2-Dimethyl-1,3-dioxolane-4-methanol 100-79-8
Price
US $550.00/kg
Min. Order
1600kg
Purity
99%
Supply Ability
32 ton
Release date
2025-08-18
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2,2-Dimethyl-1,3-dioxolane-4-methanol 100-79-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.84%
Supply Ability
1000kg
Release date
2025-07-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
Solketal 100-79-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-22

100-79-8, 2,2-Dimethyl-1,3-dioxolane-4-methanolRelated Search:

Dimethyl carbonate Dimethyl disulfide Lithium diisopropylamide Dimethyl fumarate N,N-Diisopropylethylamine Methanol 3-Methyl-2-butanone 1,3-Dioxan-5-ol Dimethyl ether Tris(hydroxymethyl)nitromethane ETHANE Chloromethyl isopropyl carbonate ISOPROPYLHYDRAZINE HYDROCHLORIDE Dimethyl sulfoxide Allyl glycidyl ether Dacthal Triisopropylsilane Glycerol

  • DL-ALPHA,BETA-ISOPROPYLIDENEGLYCEROL
  • LABOTEST-BB LT00233172
  • ISOPROPYLIDENGLYCEROL
  • ISOPROPYLIDENEGLYCEROL
  • GLYCEROL DIMETHYLKETAL
  • 2,3-O-ISOPROPYLIDENEGLYCEROL
  • (+/-)-2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL
  • 2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL
  • (+/-)-2,2-DIMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE
  • 2,2-DIMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE
  • 1,2-O-ISOPROPYLIDENEGLYCEROL
  • 1,2-ISOPROPYLIDENEGLYCEROL
  • 1,2-ISOPROPYLIDENE-RAC-GLYCEROL
  • 1,2-Isopropylideneglycerin
  • 1,2-O,O-Isopropylideneglycerin
  • (+/-)-2,2-Dimethyl-1,3-dioxolane-4-methanol~(+/-)-1,2-O-Isopropylideneglycerol
  • 4-hydroxymethyl-2,2-dimethyl-1,3-dioxolan
  • glycerol 1,2-isopropylidene ether
  • DL-1,2-Isopropylideneglycerol, 98%
  • 2,2-DIMETHYL-1,3-DIOXOLANE-4-METHANOL(SOLKETAL)
  • Glycerol α,β-isopropylidene ether
  • Dimethyl-4-hydroxymethyl-1,3-dioxolane
  • 1,3-Dioxolane-4-methanol, 2,2-dimethyl-
  • (n)-1,2-o-isopropylideneglycerol
  • (n)-2,2-dimethyl-1,3-dioxolane-4-methanol
  • ACETONE GLYCERINE KETAL
  • ACETONE KETAL OF GLYCERINE
  • SOLKETAL
  • SOLKETAL(R)
  • (R,S)-ISOPROPYLIDENE GLYCEROL
  • 2,2-Dimethyl-1,3-dioxolan-4-yl methanol
  • glycerol,1,2-o-isopropylidene
  • Glycerolacetone
  • glycerolacetonide
  • isopropylidene
  • dl-α,β-isopropylideneglycerol
  • DL-1,2-Isopropylideneglycerol 98%
  • 1,2-O-Isopropylideneglycerol for synthesis
  • Augeo SL191
  • THCB 200
  • AUGEO
  • 2,2-dimethyl-3-dioxolane-4-methanol
  • 2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxacyclopentane
  • 2,2-Dimethyl-4-hydroxymethyldioxolane
  • 2,2-Dimethyl-4-oxymethyl-1,3-dioxolane
  • 2,2-Dimethyl-5-hydroxymethyl-1,3-dioxolane
  • 1,2-isopropylidine glycerol
  • 2,3-(Isopropylidenedioxy)propanol
  • 2,3-Isopropylideneglycerol
  • 4-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxolane
  • 4-Hydroxymethyl-2,2-dimethyl-1,3-dioxolane
  • Acetone monoglycerol ketal
  • Acetone, cyclic (hydroxymethyl)ethylene acetal
  • acetone,cyclic(hydroxymethyl)ethyleneacetal
  • acetoneglycerol
  • alpha,beta-Isopropylideneglycerol
  • GIE
  • Glycerinisopropylidene ether