Ixazomib citrate
- Product Name
- Ixazomib citrate
- CAS No.
- 1239908-20-3
- Chemical Name
- Ixazomib citrate
- Synonyms
- (R)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid;lxazomib;MLN9708（b）;Ixazomib citrat;Esazomib citrate;Lxazomib Citrate;Ixazomib-prodrug;Ixazomib Citrate;Ixazomibe citrate;S-Ixazomib citrate
- CBNumber
- CB43067499
- Molecular Formula
- C20H23BCl2N2O9
- Formula Weight
- 517.12
- MOL File
- 1239908-20-3.mol
Ixazomib citrate Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);193.38(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);193.38(Max Conc. mM) - form
- Solid
- pka
- 3.59±0.10(Predicted)
- color
- White to off-white
- InChIKey
- MBOMYENWWXQSNW-AWEZNQCLSA-N
- SMILES
- O1C(=O)C(CC(O)=O)(CC(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- AG-CR1-3671-M001
- Product name
- Ixazomibcitrate[MLN9708]
- Purity
- ≥95%(1H-NMR)
- Packaging
- 1mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- CS-1720
- Product name
- Ixazomibcitrate
- Purity
- 99.80%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-1720
- Product name
- Ixazomibcitrate
- Purity
- 99.80%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- AG-CR1-3671-M005
- Product name
- Ixazomibcitrate[MLN9708]
- Purity
- ≥95%(1H-NMR)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-1720
- Product name
- Ixazomibcitrate
- Purity
- 99.80%
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
Ixazomib citrate Chemical Properties,Usage,Production
Uses
Ixazomib Citrate is a reversible boronic acid proteasome inhibitor.
Definition
ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diy }diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.
Health effects
Ixazomib citrate is an N-capped dipeptidyl leucine boronic acid like bortezomib, and it is able to inhibit the chymotrypsin-like proteolytic site of the 20S proteasome.
Side effects
Common side effects of Ixazomib citrate include diarrhea, constipation and low platelet count. Like the older bortezomib (which can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative.
in vivo
Ixazomib citrate (MLN9708; 11 mg/kg) significantly inhibits MM tumor growth and prolongs survival in the human plasmacytoma MM.1S xenograft mouse model. The blood chemistry profiles of Ixazomib-treated mice show normal levels of creatinine, hemoglobin, and bilirubin. Ixazomib dramatically increases the number of cleaved-caspase-3 positive cells of the xenograft model[2].
Ixazomib citrate Preparation Products And Raw materials
Raw materials
Preparation Products
Ixazomib citrate Suppliers
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- +16313385890
- info@protheragen-ing.com
- Country
- United States
- ProdList
- 3868
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
View Lastest Price from Ixazomib citrate manufacturers
- Product
- Ixazomib Citrate 1239908-20-3
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10kgs
- Release date
- 2024-11-05
- Product
- Ixazomib Citrate 1239908-20-3
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-13
- Product
- Ixazomib citrate (USAN) 1239908-20-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20