Methyl 3-amino-4-methylbenzoate

ChemicalBook > CAS DataBase List > Methyl 3-amino-4-methylbenzoate

Methyl 3-amino-4-methylbenzoate

Product Name: Methyl 3-amino-4-methylbenzoate
CAS No.: 18595-18-1
Chemical Name: Methyl 3-amino-4-methylbenzoate
Synonyms: AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate
CBNumber: CB4316035
Molecular Formula: C9H11NO2
Formula Weight: 165.19
MOL File: 18595-18-1.mol

Less

Methyl 3-amino-4-methylbenzoate Property

Melting point:: 113-117 °C(lit.)
Boiling point:: 296.3±20.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 3.31±0.10(Predicted)
form: Crystalline Powder
color: White to cream
BRN: 2088611
InChIKey: YEPWCJHMSVABPQ-UHFFFAOYSA-N
LogP: 1.7 at 22℃ and pH7
CAS DataBase Reference: 18595-18-1(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29224999

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002111
Product name: Nilotinib impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002111
Price: $186
Updated: 2023/01/07

TCI Chemical

Product number: A1432
Product name: Methyl 3-Amino-4-methylbenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $27
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 5g
Price: $25.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 25g
Price: $87.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 100g
Price: $229.65
Updated: 2024/03/01

Less

Methyl 3-amino-4-methylbenzoate Chemical Properties,Usage,Production

Description

Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

Beige powder

Uses

Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).

Application

Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide

Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.

Preparation

Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)

Definition

ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.

Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methyl 3-amino-4-methylbenzoate Suppliers

Americas 1 Belgium 4 China 282 Europe 3 France 1 Germany 9 India 22 Japan 2 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 17 United States 50 Global 396

Wuhan Beileye Biomedical Technology Co., Ltd.

Tel: 18086118078
Email: 2696158611@qq.com
Country: China
ProdList: 4277
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9499
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
Fax: +86 10 61256049
Email: sales@zeroschem.com
Country: China
ProdList: 1347
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8838
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

TRL Bioscience Co., Ltd.

Tel: 021-54822871 13817743194
Fax: 021-54827552
Email: info@shtrl.com
Country: China
ProdList: 93
Advantage: 62

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4552
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.

Tel: 021-69106960 13701823733
Fax: 021-69106780
Email: 13701823733@163.com
Country: China
ProdList: 4767
Advantage: 60

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2982
Advantage: 50

Beijing Xinsavi Chemical Technology Co., Ltd.

Tel: 010-56218822 13717722232
Fax: 010-56218800
Email: xinsavichem@163.com
Country: China
ProdList: 3201
Advantage: 56

Beijing Holiyang Chemical Co. Ltd.

Tel: 13718199399
Fax: QQ : 206661479
Email: holiyangchem@163.com
Country: China
ProdList: 3381
Advantage: 56

Shanghai YouPeng Chemical Co. Ltd.

Tel: 021-69005955 13701776567
Fax: 021-69005775
Email: youpengchem@163.com
Country: China
ProdList: 4293
Advantage: 56

Sichuan Hainuowei Technology Co. Ltd.

Tel: 13708085536
Fax: QQ : 121102042
Email: hanovichem@163.com
Country: China
ProdList: 3383
Advantage: 56

Less

View Lastest Price from Methyl 3-amino-4-methylbenzoate manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $106.05/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 8tons/month
Release date: 2021-09-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 10 tons
Release date: 2021-09-30

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

18595-18-1, Methyl 3-amino-4-methylbenzoateRelated Search:

Methylparaben Kresoxim-methyl Methyl benzoate 2-Amino-4-methylbenzoic acid Methyl acetate Glycine Bensulfuron methyl Methyl 2-iodobenzoate 4-Dimethylaminobenzoic acid 6-Aminocaproic acid 4-Aminobenzoic acid METSULFURON METHYL Thiophanate-methyl Methyl acrylate 3-Amino-4-methylbenzoic acid 4-Methyl-3-nitrobenzoic acid Methyl METHYL 2-AMINO-3-METHYLBENZOATE

METHYL 3-AMINO-4-METHYLBENZOATE

METHYL 3-AMINO-P-TOLUATE

LABOTEST-BB LT00848257

3-amino-2,4-dimethylbenzoate

Nilotinib Impurity 25

Nilotinib EP Impurity B

3-Amino-p-Toluic Acid Methyl Ester 3-Amino-4-Methyl Benzoic Acid Methyl Ester

3-Amino-4-Methylbenzoate

3-Amino-p-toluic

Methyl 3-amino-4-methylbenzoate 98%

Methyl 3-Amion-4-Methylbenzoate

AKOS BB-3092

3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER

3-AMINO-P-TOLUIC ACID METHYL ESTER

Methyl4-Methyl-3-Aminobenzoate

Methyl 3-amino-4-met

3-Amino-4-methylbenzoic Acid Methyl Ester Methyl 3-Amino-p-toluate 3-Amino-p-toluic Acid Methyl Ester

Methyle3-amino-4-methylbenzoate

5-(Methoxycarbonyl)-2-methylaniline, 2-Amino-4-(methoxycarbonyl)toluene, 5-(Methoxycarbonyl)-o-toluidine

Benzoic acid, 3-aMino-4-Methyl-, Methyl ester

Methyl-3-amino-4-methylbenozate

Methyl 3-Amino-4-methylbenzoate &gt

Methyl 3-amino-4-methylbenzoate 18595-18-1

Nilotinib USP Related Compound B

Benzoic acid, 3-amino-4-methyl-, methyl ester (9CI, ACI)

3-amino-4-methyl-Benzoic acid methyl ester (9CI ACI)

Compound Fr13901

Nilotinib Hydrochloride Monohydrate EP Impurity B

Nilotinib Impurity 17(Nilotinib EP Impurity B)

18595-18-1

18585-18-1

Esters

Organic Building Blocks

Building Blocks

Carbonyl Compounds

C8 to C9

Building Blocks

C8 to C9

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aromatic Esters

Esters

Phenyls & Phenyl-Het

FINE Chemical & INTERMEDIATES

Acids and Derivatives

Amines and Anilines

bc0001