ChemicalBook > CAS DataBase List > Methyl 3-amino-4-methylbenzoate
Methyl 3-amino-4-methylbenzoate
- Product Name
- Methyl 3-amino-4-methylbenzoate
- CAS No.
- 18595-18-1
- Chemical Name
- Methyl 3-amino-4-methylbenzoate
- Synonyms
- AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate
- CBNumber
- CB4316035
- Molecular Formula
- C9H11NO2
- Formula Weight
- 165.19
- MOL File
- 18595-18-1.mol
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Methyl 3-amino-4-methylbenzoate Property
- Melting point:
- 113-117 °C(lit.)
- Boiling point:
- 296.3±20.0 °C(Predicted)
- Density
- 1.132±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 3.31±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to cream
- BRN
- 2088611
- InChIKey
- YEPWCJHMSVABPQ-UHFFFAOYSA-N
- LogP
- 1.7 at 22℃ and pH7
- CAS DataBase Reference
- 18595-18-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- Y0002111
- Product name
- Nilotinib impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0002111
- Price
- $186
- Updated
- 2023/01/07
TCI Chemical
- Product number
- A1432
- Product name
- Methyl 3-Amino-4-methylbenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $27
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15348
- Product name
- Methyl 3-amino-4-methylbenzoate, 97%
- Packaging
- 5g
- Price
- $25.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15348
- Product name
- Methyl 3-amino-4-methylbenzoate, 97%
- Packaging
- 25g
- Price
- $87.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15348
- Product name
- Methyl 3-amino-4-methylbenzoate, 97%
- Packaging
- 100g
- Price
- $229.65
- Updated
- 2024/03/01
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Methyl 3-amino-4-methylbenzoate Chemical Properties,Usage,Production
Description
Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Chemical Properties
Beige powder
Uses
Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).
Application
Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide
Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.
Preparation
Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)
Definition
ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.
Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 3-amino-4-methylbenzoate manufacturers
Asia Chem I and E (Jiangsu) Co Ltd
- Product
- Methyl 3-amino-4-methylbenzoate 18595-18-1
- Price
- US $106.05/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 99.00%HPLC
- Supply Ability
- 8tons/month
- Release date
- 2021-09-22
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Methyl 3-amino-4-methylbenzoate 18595-18-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 10 tons
- Release date
- 2021-09-30
Henan Aochuang Chemical Co.,Ltd.
- Product
- Methyl 3-amino-4-methylbenzoate 18595-18-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
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