Methyl 3-amino-4-methylbenzoate

Product Name: Methyl 3-amino-4-methylbenzoate
CAS No.: 18595-18-1
Chemical Name: Methyl 3-amino-4-methylbenzoate
Synonyms: AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate
CBNumber: CB4316035
Molecular Formula: C9H11NO2
Formula Weight: 165.19
MOL File: 18595-18-1.mol

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Methyl 3-amino-4-methylbenzoate Property

Melting point:: 113-117 °C(lit.)
Boiling point:: 296.3±20.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 3.31±0.10(Predicted)
form: Crystalline Powder
color: White to cream
BRN: 2088611
InChIKey: YEPWCJHMSVABPQ-UHFFFAOYSA-N
LogP: 1.7 at 22℃ and pH7
CAS DataBase Reference: 18595-18-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002111
Product name: Nilotinib impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002111
Price: $186
Updated: 2023/01/07

TCI Chemical

Product number: A1432
Product name: Methyl 3-Amino-4-methylbenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $27
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 5g
Price: $25.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 25g
Price: $87.65
Updated: 2024/03/01

Alfa Aesar

Product number: A15348
Product name: Methyl 3-amino-4-methylbenzoate, 97%
Packaging: 100g
Price: $229.65
Updated: 2024/03/01

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Methyl 3-amino-4-methylbenzoate Chemical Properties,Usage,Production

Description

Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Chemical Properties

Beige powder

Uses

Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).

Application

Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide

Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.

Preparation

Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)

Definition

ChEBI: Methyl 3-amino-4-methylbenzoate is a benzoate ester.

Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-amino-4-methylbenzoate Suppliers

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View Lastest Price from Methyl 3-amino-4-methylbenzoate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 10 tons
Release date: 2021-09-30

Asia Chem I and E (Jiangsu) Co Ltd

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $106.05/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 8tons/month
Release date: 2021-09-22

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 3-amino-4-methylbenzoate 18595-18-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

18595-18-1, Methyl 3-amino-4-methylbenzoateRelated Search:

Methylparaben Kresoxim-methyl Methyl benzoate 2-Amino-4-methylbenzoic acid Methyl acetate Glycine Bensulfuron methyl Methyl 2-iodobenzoate 4-Dimethylaminobenzoic acid 6-Aminocaproic acid 4-Aminobenzoic acid METSULFURON METHYL Thiophanate-methyl Methyl acrylate 3-Amino-4-methylbenzoic acid 4-Methyl-3-nitrobenzoic acid Methyl METHYL 2-AMINO-3-METHYLBENZOATE

METHYL 3-AMINO-4-METHYLBENZOATE

METHYL 3-AMINO-P-TOLUATE

LABOTEST-BB LT00848257

3-amino-2,4-dimethylbenzoate

Nilotinib Impurity 25

Nilotinib EP Impurity B

3-Amino-p-Toluic Acid Methyl Ester 3-Amino-4-Methyl Benzoic Acid Methyl Ester

3-Amino-4-Methylbenzoate

3-Amino-p-toluic

Methyl 3-amino-4-methylbenzoate 98%

Methyl 3-Amion-4-Methylbenzoate

AKOS BB-3092

3-AMINO-4-METHYLBENZOIC ACID METHYL ESTER

3-AMINO-P-TOLUIC ACID METHYL ESTER

Methyl4-Methyl-3-Aminobenzoate

Methyl 3-amino-4-met

3-Amino-4-methylbenzoic Acid Methyl Ester Methyl 3-Amino-p-toluate 3-Amino-p-toluic Acid Methyl Ester

Methyle3-amino-4-methylbenzoate

5-(Methoxycarbonyl)-2-methylaniline, 2-Amino-4-(methoxycarbonyl)toluene, 5-(Methoxycarbonyl)-o-toluidine

Benzoic acid, 3-aMino-4-Methyl-, Methyl ester

Methyl-3-amino-4-methylbenozate

Methyl 3-Amino-4-methylbenzoate &gt

Methyl 3-amino-4-methylbenzoate 18595-18-1

Nilotinib USP Related Compound B

Benzoic acid, 3-amino-4-methyl-, methyl ester (9CI, ACI)

3-amino-4-methyl-Benzoic acid methyl ester (9CI ACI)

Compound Fr13901

Nilotinib Hydrochloride Monohydrate EP Impurity B

Nilotinib Impurity 17(Nilotinib EP Impurity B)

18595-18-1

18585-18-1

Esters

Organic Building Blocks

Building Blocks

Carbonyl Compounds

C8 to C9

Building Blocks

C8 to C9

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aromatic Esters

Esters

Phenyls & Phenyl-Het

FINE Chemical & INTERMEDIATES

Acids and Derivatives

Amines and Anilines

bc0001