Azido-PEG6-NHS ester
- Product Name
- Azido-PEG6-NHS ester
- CAS No.
- 2055014-64-5
- Chemical Name
- Azido-PEG6-NHS ester
- Synonyms
- CAS_2055014-64-5;N3-PEG6-CH2CH2COONHS;Azido-PEG6-NHS ester;Azido-PEG6-NHS eater;N3-PEG5-CH2CH2COONHS Ester;Azido-PEG6-NHS ester,N3-PEG6-NHS;2,5-dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate;N3-PEG6-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-azido-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB43162882
- Molecular Formula
- C19H32N4O10
- Formula Weight
- 476.48
- MOL File
- 2055014-64-5.mol
Azido-PEG6-NHS ester Property
- storage temp.
- Storage temp. -20°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
- Appearance
- pale yellow liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- POL0002371
- Product name
- AZIDO-PEG6-NHS ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.79
- Updated
- 2021/12/16
- Product number
- BIPG1158
- Product name
- Azido-PEG6-NHS ester
- Packaging
- 100mg
- Price
- $546
- Updated
- 2021/12/16
- Product number
- BP-21506
- Product name
- Azido-PEG6-NHSester
- Purity
- 98%
- Packaging
- 1g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- AS107818
- Product name
- N3-PEG6-CH2CH2COONHS
- Purity
- 97%
- Packaging
- 1g
- Price
- $969
- Updated
- 2021/12/16
- Product number
- 436906
- Product name
- N3-PEG6-CH2CH2COONHSEster
- Purity
- min.97%
- Packaging
- 500mg
- Price
- $260
- Updated
- 2021/12/16
Azido-PEG6-NHS ester Chemical Properties,Usage,Production
Description
Azido-PEG6-NHS ester consist of an azide(N3) and an NHS ester function group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
Uses
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs; Alkyl/ether; Cleavable Linker
References
[1] Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717. DOI:10.1002/anie.201709532
[2] John W. Babich, et al. Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies. WO2018187631A1.
Azido-PEG6-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azido-PEG6-NHS ester manufacturers
- Product
- N3-PEG6-NHS 2055014-64-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-03
- Product
- Azido-PEG6-NHS ester 2055014-64-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23